In recent years, many researchers pay more attention to abnormities before earthquake, and in this study, seismo‐ionospheric synchronous disturbances at different altitudes by GPS and satellite observations were first studied around one Sumatra Indonesia Ms 7.2 earthquake that occurred on 5 July 2005. By using the same temporal and spatial methods, data of GPS‐total electron content (TEC) from Jet Propulsion Laboratory, electron density (Ne) from Detection of Electro‐Magnetic Emissions Transmitted from Earthquake Regions, and ion density (Ni) from Defense Meteorological Satellite Program were deeply analyzed. The ionospheric plasma disturbances in GPS‐TEC and increasement of Ne at 710 km were found on 4 July, and plasma density at the three altitudes has all increased on 7 July after the earthquake. All the disturbances were not just above the epicenter. TEC perturbations have happened at the east of the epicenter for the two days, and electron density enhancement at 710 km has moved to west of the TEC perturbations at the same time on 4 July, which may be caused by E × B drift. The moving direction of upgoing plasma was simulated using SAMI2 model. The results have shown that the plasma will move to higher altitude along the geomagnetic force line, which could exactly account for the plasma density enhancement in the northern direction of the geomagnetic south latitude earthquake.