New World and Old World Leishmania Infections

Kevric, Ines; Cappel, Mark A.; Keeling, James H.

doi:10.1016/j.det.2015.03.018

Cited by 258 publications

(222 citation statements)

References 83 publications

Supporting

Mentioning

195

Contrasting

Unclassified

Order By: Relevance

“…Mortality is estimated at 20,000-30,000 annually, second only to malaria for diseases caused by a protozoan [37]. More than 90 % of New World cutaneous disease originates from Brazil and Peru; Old World disease originates mostly from Iran, Afghanistan, Syria, and Saudi Arabia [38,39].…”

Section: Epidemiologymentioning

confidence: 99%

“…This can lead to mutilating destruction of the mucous membranes and surrounding cartilage; most classically, ulceration of the septal mucosae. Progression rates to mucocutaneous leishmaniasis range from 1 to 10 % [37,42,43]. The disseminated form of leishmaniasis, known as visceral disease or Kala-azar (black sickness) is caused by migration of infected tissue macrophages through the reticuloendothelial system.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Visceral leishmaniasis can originate from either Old or New World Fig. 6 Cutaneous leishmaniasis disease, with patients from Bangladesh, Brazil, Ethiopia, India, Sudan, and South Sudan accounting for [90 % of cases [37].…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Skin biopsy reveals a dense dermal mixed infiltrate with histiocytes, lymphocytes, neutrophils, and plasma cells. Intracellular amastigotes may be present within inflammatory cells, though sensitivity for the organism is highly variable, ranging from 19 to 77 % [37,44]. Polymerase chain reaction (PCR) helps to confirm the diagnosis, either with a skin biopsy specimen or fine needle aspirate.…”

Section: Clinical Presentationmentioning

confidence: 99%

See 3 more Smart Citations

Got the Travel Bug? A Review of Common Infections, Infestations, Bites, and Stings Among Returning Travelers

2016

View full text Add to dashboard Cite

The popularity of international travel continues to increase among Americans, even though they often experience subsequent illness on return from their journey. The pathogens responsible are not necessarily endemic to the destination itself but are often the result of poor sanitary conditions or activities engaged in while away. Skin disease ranks third among all medical concerns in returning travelers. This review addresses the pathogenesis, epidemiology, clinical presentation, and treatment of the most common skin diseases in returning travelers: insect bites and bedbugs, cutaneous larva migrans, scabies, tungiasis, myiasis, leishmaniasis, viral exanthems, and marine envenomation. Primary care physicians and dermatologists should be familiar with these illnesses and a general approach to their evaluation and management. Key PointsArthropod assault and infestation is a source of significant morbidity in returning travelers.Travelers should bring proper protective clothing and insect repellant when travelling to areas where biting insects are vectors of disease.Travelers should be acquainted with the hazards associated with local marine life if they plan on entering the water.

show abstract

Section: Epidemiologymentioning

confidence: 99%

Section: Clinical Presentationmentioning

confidence: 99%

Section: Clinical Presentationmentioning

confidence: 99%

Section: Clinical Presentationmentioning

confidence: 99%

See 2 more Smart Citations

Got the Travel Bug? A Review of Common Infections, Infestations, Bites, and Stings Among Returning Travelers

2016

View full text Add to dashboard Cite

show abstract

“…Existem três formas da doença dependendo da espécie de Leishmania infectante e da imunidade do hospedeiro: (i) a leishmaniose cutânea (LC) (forma mais comum da doença); (ii) a leishmaniose mucocutânea (LMC) (forma menos comum, causada por algumas espécies do parasito); e a leishmaniose visceral (LV), muitas vezes conhecida como calazar (forma mais grave da doença) (Kevric et al, 2015;WHO, 2015).…”

Section: Leishmanioseunclassified