Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity

Dziadek, Michał; Dziadek, Kinga; Salagierski, Szymon; Drozdowska, Mariola; Serafim, Andrada; Stancu, Izabela‐Cristina; Szatkowski, Piotr; Kopeć, Aneta; Rajzer, I.; Douglas, Timothy; Cholewa‐Kowalska, Katarzyna

doi:10.1016/j.carbpol.2022.119486

Cited by 55 publications

(22 citation statements)

References 47 publications

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“…For PP loaded tablets, antioxidant activity varying between 60 and 75% and phenolic content results of 3D tablets can be clearly ascribed to the presence of phenolic components coming from PP in the formulations. This is in agreement with previous studies [12]. Natural phenolic compounds could be negatively affected from temperature, light, etc.…”

Section: Discussionsupporting

confidence: 94%

Antioxidant Properties of SLA Printed Hydrogels Enriched with Pomegranate Powder

Erünsal

Aydoğdu

2022

EJRnD

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3D printing (3DP) is a powerful platform for fabrication of complex or personalized geometries. Hydrogels as attractive candidates for wound dressing, soft implant, encapsulation of phenolic compounds, drug delivery, etc. could be manufactured by using different 3D printing techniques. In this study, encapsulation of pomegranate powder into PEGDMA gel by Stereolithography (SLA) printing was investigated and then antioxidant activity and total phenolic content of printed gels with varying shapes were examined to see the effect of different geometry and process conditions. According to the results, pomegranate based blend was successfully incorporated into gel matrix and printed with high printability ratio at optimized 3D printing conditions. UV induced gelation did not prevent existence of phenolic compounds and allowed retention of antioxidant potential in printed samples. Obtained hydrogels represent promising biomaterials with great potential for the use in different applications such as antioxidant gel for tissue engineering, wound healing or as a nutraceutical carrier.

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Section: Discussionsupporting

confidence: 94%

Antioxidant Properties of SLA Printed Hydrogels Enriched with Pomegranate Powder

Erünsal

Aydoğdu

2022

EJRnD

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“…Moreover, in vivo experiment results confirm the ability of CTS-based hydrogels to accelerate tissue regeneration to reduce inflammation and facilitate wound healing [ 102 , 103 ]. Current trends in CTS-based hydrogels for biomedical applications focus on the improvement of CTS performance and properties, from cross-linking strategies [ 99 , 100 , 101 , 188 ] to blending [ 189 , 190 , 191 ] and functionalization of CTS structure [ 192 , 193 ].…”

Section: Methodsmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

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Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced and solved. Hydrogels have been proposed as excellent candidates for these applications, as they have promising properties for the mentioned applications, including biocompatibility, biodegradability, great absorption capacity and tunable mechanical properties. However, depending on the material or the manufacturing method, the resulting hydrogel may not be up to the specific task for which it is designed, thus there are different approaches proposed to enhance hydrogel performance for the requirements of the application in question. The main purpose of this review article was to summarize the most recent trends of hydrogel technology, going through the most used polymeric materials and the most popular hydrogel synthesis methods in recent years, including different strategies of enhancing hydrogels’ properties, such as cross-linking and the manufacture of composite hydrogels. In addition, the secondary objective of this review was to briefly discuss other novel applications of hydrogels that have been proposed in the past few years which have drawn a lot of attention.

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“…Chitosan is originated from partial deacetylation of chitin, which is the second largest natural polymer only after cellulose. 23,24 Chitosan contains hydroxyl, amino, and acetylamino groups, so it has many unique properties as biodegradability, cell affinity and biological effect. 25 Moreover, as the only basic polysaccharide in nature, chitosan possesses many physiological functions as bacteriostasis, anti-cancer, lipid-lowering, enhancing immunity and so on attributing to the free amino group.…”

Section: Introductionmentioning

confidence: 99%

“…Chitosan is a natural material with great potential for the skeleton of hydrogels because of its easy formation of hydrogen bonds. Chitosan is originated from partial deacetylation of chitin, which is the second largest natural polymer only after cellulose 23,24 . Chitosan contains hydroxyl, amino, and acetylamino groups, so it has many unique properties as biodegradability, cell affinity and biological effect 25 .…”

Section: Introductionmentioning

confidence: 99%

Rapid gelation of dual physical network hydrogel with ultra‐stretchable, antifreezing, moisturing for stable and sensitive response

Zhang

Chen

et al. 2023

J of Applied Polymer Sci

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Dual physical network hydrogel possesses robust energy dissipation mechanism. However, the demanding conditions of the second monomer radical polymerization aren't benefit for the dispersion of conductive filler. Moreover, the stable and sensitive response under extreme environment puts forward the requirements for mechanical, antifreezing and moisture retention properties. Herein, a dual physical networks hydrogel (polyacrylic acid-chitosan-graphene/glycerol, noted as PAA-CS-G/Gly) was prepared rapidly (<0.5 h) without chemical crosslinking agents at room temperature. The rapid gelation, ionic coordination of Ag + together with certain viscosity chitosan promoted the dispersion of graphene. PAA-CS-G/Gly showed ultra-stretchable properties ($2500%), good toughness (3.11 MJ/m 3 ), breaking strength (0.27 MPa) and fatigue resistance. PAA-CS-G/Gly had good adhesion properties, outstanding tolerance for freezing (À80 C) and moisture retention. More importantly, PAA-CS-G/Gly strain sensor had excellent sensitivity (GF, up to 9.449) at 300% $ 900% strain. It could sensitively detect human joint movements and even subtle activities such as talking and swallowing. PAA-CS-G/Gly hydrogel is expected to adhere directly to the human body for flexible monitoring of human size movement under extreme environmental conditions.

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Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity

Cited by 55 publications

References 47 publications

Antioxidant Properties of SLA Printed Hydrogels Enriched with Pomegranate Powder

Antioxidant Properties of SLA Printed Hydrogels Enriched with Pomegranate Powder

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Rapid gelation of dual physical network hydrogel with ultra‐stretchable, antifreezing, moisturing for stable and sensitive response

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