Newly Diagnosed Idiopathic Thrombocytopenia Post COVID-19 Vaccine Administration

Vincristine therapy for severe and refractory immune thrombocytopenia following COVID-19 vaccination

“…Although most cases of COVID-19 vaccine-related ITP were responsive to initial treatment with steroids and/or IVIG [1,[4][5][6][7], some patients died of intracranial hemorrhage according to reports from the Vaccine Adverse Event Reporting System [9]. Although the present case showed a very high risk of life-threatening hemorrhage, vincristine yielded a rapid response.…”

“…Thrombocytopenia after COVID-19 vaccination accompanied by thrombosis is usually reported as thrombosis with thrombocytopenia syndrome or vaccine-induced immune thrombotic thrombocytopenia [3], which is associated with anti-PF4 antibodies and usually develops after inoculation with adenoviral vector-based vaccines. Further, ITP after COVID-19 vaccination usually presents with severe thrombocytopenia and hemorrhagic symptoms [1,[4][5][6][7]. The present case was considered vaccine-associated ITP, established by the presence of serum anti-glycoprotein IIb/IIIa antibody, one of the platelet autoantibodies [8].…”

Propylthiouracil-Induced Antineutrophil Cytoplasmic Antibody-Associated Vasculitis after COVID-19 Vaccination

“…There are still concerns about unknown long-term adverse effects of the vaccine [ 23 ]. Several cases of thrombocytopenia have been reported after the administration of mRNA vaccines [ 5 , 6 , 7 , 8 ]. In a report from the U.S. of 20 patients who developed thrombocytopenia after vaccination, nine patients had received the Pfizer–BioNTech vaccine and 11 received the Moderna vaccine [ 6 ].…”

“…However, there is still a lack of data on the BNT162b2 mRNA vaccine for medium- to long-term safety, interaction with other drugs, and use in subjects with underlying medical conditions. Immune thrombocytopenia (ITP) after COVID-19 vaccination has been reported and is more common with the adenovirus vectored vaccine ChAdOx1 nCoV-19 (AstraZeneca) [ 4 ], but has also been reported with mRNA vaccines [ 5 , 6 , 7 , 8 ]. No other autoimmune diseases have been reported to be associated with mRNA COVID-19 vaccines.…”

A Case Report of Immune Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination

“… 3 Several cases of ITP, regardless of probable association with the vaccination, have been reported following SARS-CoV-2 immunization, mostly in the United Kingdom and the United States. 4 5 6 7 8 9 We present a case of ITP occurring after ChAdOx1 nCoV-19 vaccination.…”