Newly identified lncRNA-45 promotes breast cancer metastasis through activating the mTOR signaling pathway

“…Therefore, it is generally accepted that autophagy is degraded and recycled to inhibit tumor development ( Russell and Guan, 2022 ). However, as cancer develops, the process of autophagy has been shown to be necessary to support uncontrolled growth and progressively increased metabolic activity of tumor cells, leading to tumor dependence on autophagy ( Miller and Thorburn, 2021 ; Qiu et al, 2023 ). At this stage, aberrant autophagy may contribute to tumor cell proliferation and ongoing tumor progression by promoting cancer stem cell spreading ( Ariosa et al, 2021a ).…”

Section: Overview Of Lncrnamentioning

confidence: 99%

“…Analogously, lncRNA-45, a newly identified lncRNA that is transcribed by an internal region within the mTOR complex one gene, is the most upregulated lncRNA. It makes a contribution to BC cells invade and metastasize through activation of mTOR and inhibition of autophagy ( Qiu et al, 2023 ). In addition, LacRNA (a novel LINC00478-associated cytoplasmic RNA) obviously blocked BC cell invasion and metastasis in vitro and in vivo via inhibiting the degradation of autophagy ( Guo et al, 2023 ).…”

Section: Lncrna-mediated Autophagy In Cancersmentioning

confidence: 99%

The role of LncRNA-mediated autophagy in cancer progression

Liu,

Tang,

Yang

et al. 2024

Front. Cell Dev. Biol.

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Long non-coding RNAs (lncRNAs) are a sort of transcripts that are more than 200 nucleotides in length. In recent years, many studies have revealed the modulatory role of lncRNAs in cancer. Typically, lncRNAs are linked to a variety of essential events, such as apoptosis, cellular proliferation, and the invasion of malignant cells. Simultaneously, autophagy, an essential intracellular degradation mechanism in eukaryotic cells, is activated to respond to multiple stressful circumstances, for example, nutrient scarcity, accumulation of abnormal proteins, and organelle damage. Autophagy plays both suppressive and promoting roles in cancer. Increasingly, studies have unveiled how dysregulated lncRNAs expression can disrupt autophagic balance, thereby contributing to cancer progression. Consequently, exploring the interplay between lncRNAs and autophagy holds promising implications for clinical research. In this manuscript, we methodically compiled the advances in the molecular mechanisms of lncRNAs and autophagy and briefly summarized the implications of the lncRNA-mediated autophagy axis.

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“…Mechanistically, lncRNA-45 was reported to increase EMT, significantly impacting the BC cell’s ability to migrate and invade. Identification of lncRNA-45 function enabled further investigation of molecular mechanisms that are employed in metastatic vs. primary BC [ 72 ]. Therefore, uniformity in tumor profiling may be accomplished at the RNA level.…”

Section: Rna Molecules As Prognostic Factorsmentioning

confidence: 99%

Interactome of Long Non-Coding RNAs: Transcriptomic Expression Patterns and Shaping Cancer Cell Phenotypes

DeSouza

Quaranto

Carnazza

et al. 2023

IJMS

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RNA biology has gained extensive recognition in the last two decades due to the identification of novel transcriptomic elements and molecular functions. Cancer arises, in part, due to the accumulation of mutations that greatly contribute to genomic instability. However, the identification of differential gene expression patterns of wild-type loci has exceeded the boundaries of mutational study and has significantly contributed to the identification of molecular mechanisms that drive carcinogenic transformation. Non-coding RNA molecules have provided a novel avenue of exploration, providing additional routes for evaluating genomic and epigenomic regulation. Of particular focus, long non-coding RNA molecule expression has been demonstrated to govern and direct cellular activity, thus evidencing a correlation between aberrant long non-coding RNA expression and the pathological transformation of cells. lncRNA classification, structure, function, and therapeutic utilization have expanded cancer studies and molecular targeting, and understanding the lncRNA interactome aids in defining the unique transcriptomic signatures of cancer cell phenotypes.

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Newly identified lncRNA-45 promotes breast cancer metastasis through activating the mTOR signaling pathway

Cited by 6 publications

References 39 publications

Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword

Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword

The role of LncRNA-mediated autophagy in cancer progression

Interactome of Long Non-Coding RNAs: Transcriptomic Expression Patterns and Shaping Cancer Cell Phenotypes

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