Newly recognized bocaviruses (HBoV, HBoV2) in children and adults with gastrointestinal illness in the United States

Chow, Brian; Ou, Zhen; Esper, Frank

doi:10.1016/j.jcv.2009.11.030

Cited by 69 publications

(74 citation statements)

References 34 publications

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“…Based on the mean occurrence of other gastroenteric viruses in the region, HBoV-1 could be considered the third most common after RVAs and human cali-civiruses (Cardoso et al 2003, Costa et al 2004, Borges et al 2006, Andreasi et al 2008. Additionally, it must be noted that primer pairs that detect only HBoV species 1 and 3 were used in this study and if one considers that species 2 appears to be predominant in individuals with gastroenteritis (Arthur et al 2009, Chow et al 2010, the observed positivity rate for HBoVs may be underestimated. Therefore, future studies should be conducted to confirm this assumption.…”

Section: Discussionmentioning

confidence: 91%

“…HBoV detection in faecal samples from individuals with acute gastroenteritis has gained importance following the positive identification of bocavirus in faecal samples from individuals throughout the world (Albuquerque et al 2007, Lau et al 2007, Monteny et al 2007, Vicente et al 2007, Han et al 2009, Chow et al 2010, Kantola et al 2010, Jin et al 2011. In Brazil, only three studies have been published regarding HBoV detection in children with acute gastroenteritis (Albuquerque et al 2007, Santos et al 2010, Proença-Modena et al 2011 and this is the first study conducted in the Central-West Region of Brazil.…”

Section: Discussionmentioning

confidence: 99%

“…The inability to elucidate this role could be attributed, in part, to the frequent association of HBoVs with other gastroenteric viruses (Albuquerque et al 2007, Arthur et al 2009, Nakanishi et al 2009, Chow et al 2010. Studies conducted in Japan, Australia and South Korea have observed an association of HBoV with RVAs, adenoviruses, astroviruses and caliciviruses with a higher frequency Phylogenetic analysis of the nucleotide sequences from a region of the human bocaviruses (HBoVs) gene.…”

Section: Discussionmentioning

confidence: 99%

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Human bocavirus 1 and 3 infection in children with acute gastroenteritis in Brazil

Sousa¹,

Souza²,

Fiaccadori³

et al. 2012

Mem. Inst. Oswaldo Cruz

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To determine the positivity rate of human bocavirus (HBoV) 1 and 3 among children who presented with acute gastroenteritis symptoms during the period of 1994-2004 in the Central-West Region of Brazil, 762 faecal samples were tested using polymerase chain reaction (PCR) for the detection of HBoV DNA. Primers for a segment of the non-structural viral protein 1 (NS1) gene of HBoV-1 and HBoV-3 were used. Twelve HBoV-positive samples were further characterised via genomic sequencing and phylogenetic analysis. Of the samples tested, 5.8% (n = 44) were positive for HBoV-1 or HBoV-3 and co-infection was observed in 14 (31.8%) of the 44 HBoV-positive samples. Nine of the 14 samples were also positive for Rotavirus A and five were positive for Aichi virus. The genomic sequencing of the NS1 partial sequence of 12 HBoV-samples showed that 11 samples were characterised as HBoV-1 and that one was characterised as HBoV-3. The phylogenetic analysis showed that the HBoV-1 samples had a high sequence homology to others previously identified in China, Sweden and Brazil. This is the first study conducted in the Central-West Region of Brazil to detect HBoV-1 and HBoV-3 in faecal samples from children with acute gastroenteritis. Further studies are required to define the role of HBoVs as aetiological agents of gastroenteritis

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Human bocavirus 1 and 3 infection in children with acute gastroenteritis in Brazil

Sousa¹,

Souza²,

Fiaccadori³

et al. 2012

Mem. Inst. Oswaldo Cruz

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“…These data are confirmed by clinical observations indicating that the infection manifests as a respiratory condition. In contrast, hBoV2, hBoV3 and hBoV4 colonize the gastrointestinal tract; hBoV2 and possibly hBoV3 are associated with gastroenteritis [46,47]. Interestingly, hBoV2 is the only intestinal bocavirus isolated from a nasal swab; therefore it may be associated with respiratory diseases [48,49].…”

Section: Human Bocavirusmentioning

confidence: 99%

Emergence of new infections in the 21st century and identification of pathogens using next generation sequencing

et al. 2017

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Каждое новое инфекционное заболевание может быть серьезным вызовом для современной медицины. Измене-ние окружающей среды, вырубка тропических лесов, таяние льдов в Антарктике, увеличение плотности населения и повсеместное использование антибиотиков -все это факторы, провоцирующие появление новых патогенов. Эпидемии гриппа, вызываемые новыми штаммами вируса; респираторные синдромы, вызываемые новыми коро-навирусами; вспышки инфекций, причиной которых является гемолитическая кишечная палочка; возникновение резистентных к антибиотикам супербактерий -примеры того, какие опасности могут поджидать человечество. В число первоочередных мер, которые необходимо предпринять для противодействия новым патогенам, входит раз-работка способов их быстрой и точной идентификации. В обзоре рассмотрены случаи возникновения в XXI веке новых инфекционных агентов, а также проанализированы возможность и перспективы использования для выявления и идентификации новых патогенов методов высокопроизводительного секвенирования (next generation sequence).Ключевые слова: инфекционные агенты, патогенные организмы, методы выявления новых патогенов, высокопроиз-водительное секвенирование, коронавирус, вирус гриппа, горизонтальный перенос генов, антибиотикорезистентность CENTURY AND IDENTIFICATION OF PATHOGENS USING NEXT GENERATION SEQUENCINGEach new emerging infection may become a big challenge to the medical community. Changing environment, tropical deforestation, melting of the Antarctic ice, growing population density and uncontrolled use of antibiotics provoke emergence and evolution of pathogens. Epidemics caused by new strains of the influenza virus, respiratory syndromes associated with coronaviruses, outbreaks of hemolytic Escherichia coli infections and antibiotic-resistant superbacteria are hazards to humans. Among high-priority measures for pathogen control that are yet to be taken is development of fast and accurate techniques for pathogen identification. Our review looks at the cases of new infections registered in the 21 st century and explores feasibility of next generation sequencing for the detection and identification of new pathogens.

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“…The virus contains a single linear positive-sense and negative-sense single-stranded deoxyribonucleic acid (DNA). Currently, bocaviruses can be classified based on their genetic variability into species 1 to 4 [6]. Initially, only two genotypes were described in the literature as ST1 and ST2 [7].…”

Section: Introductionmentioning

confidence: 99%

Molecular detection and phylogenetic analysis of Kenyan human bocavirus isolates

Misigo

Mwaengo

Mburu

2014

J Infect Dev Ctries

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Introduction: The commonly expected causative agents associated with flu-like symptoms in Kenya are the classical viral pathogens identifiable as influenza virus, adenovirus, parainfluenza virus, enteroviruses, respiratory syncytial virus (RSV) and rhinovirus. However, newer agents have been identified globally that present with illnesses clinically indistinguishable from those caused by the classical pathogens; one of them is human bocavirus. Methodology: A total of 384 specimens were analyzed, primarily to determine if the emerging human bocavirus (HBoV) infections exist in Kenya as coinfections with other respiratory viruses and to describe the genotype of the virus in circulation. In brief, viral nucleic acids were extracted from culture supernatants, amplified by PCR, and sequenced. Results: HBoV DNA was amplified from 1.8% of screened specimens. Coinfection with parainfluenza virus, adenovirus, and enterovirus was 2.5%, 2%, and 1.4%, respectively. Multiple coinfections consisting of HBoV plus two other viruses were found in 3% of specimens. Isolation occurred in the months of January, March, April, August, and November. Retrospective review of clinical parameters indicated that all the individuals complained of non-specific symptoms, mainly fever, coughs, nasal stuffiness, runny noses, and vomiting. Phylogenetically, the GenBank deposited sequences of this study's isolates cluster closely to the reference strain NC_07455 (HBoV1). Conclusion: Coinfections with human bocavirus (HBoV1) occur in Kenya, and high incidence might primarily be during the early stages of children's lives.

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Newly recognized bocaviruses (HBoV, HBoV2) in children and adults with gastrointestinal illness in the United States

Cited by 69 publications

References 34 publications

Human bocavirus 1 and 3 infection in children with acute gastroenteritis in Brazil

Human bocavirus 1 and 3 infection in children with acute gastroenteritis in Brazil

Emergence of new infections in the 21st century and identification of pathogens using next generation sequencing

Molecular detection and phylogenetic analysis of Kenyan human bocavirus isolates

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