Newly reported alkaloids produced by marine-derived Penicillium species (covering 2014–2018)

Zhang, Peng; Qian, Wei; Yuan, Xiaolong; Xu, Kuo

doi:10.1016/j.bioorg.2020.103840

Cited by 52 publications

(51 citation statements)

References 75 publications

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“…The cytotoxicity of isolated compounds can be further compared with the standard drug such as doxorubicin which possessed high anticancer activity (IC50 0.47-8.03 µM). 23 Intens.…”

Section: Resultsmentioning

confidence: 99%

Comparative Chemical Composition and In-Vitro Cytotoxic Activity of Syzygium aromaticum against Selected Cancer Cell Lines

2021

TJNPR

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The most common deaths result from lung, colorectal, stomach, liver, and breast cancers. 3 Medicinal plants have played a significant part as sources of anticancer compounds. Examples of anticancer agents derived from plants include the vinca alkaloids from Madagascar periwinkle, isoquinoline alkaloids from the Opium poppy, camptothecin derivatives from camptotheca spp, taxane derivatives from Pacific yew tree, podophyllotoxin derivatives from Mayapple, and cannabinoids from cannabis. 4 The investigation of plants continue to hold a promise for the treatment of cancer. In this study, extracts of flower buds, young flower buds, leaves and young leaves of S. aromaticum were evaluated for their cytotoxic activity against A549 (lung carcinoma), HT-29 (colorectal adenocarcinoma), Hela (cervical adenocarcinoma), and MDA-MB-231 (breast adenocarcinoma) cell lines. The study also intends to validate the plant extracts as an alternative source of anticancer agents. Furthermore, a comparative analysis of phenolic compounds in the plant extracts was carried out. Materials and Methods Plant material and chemicals S. aromaticum sample was collected from Chanthaburi province, Thailand in September 2020, and identified by Apiradee Korpphaiboon, a Botanist in the Department of Agriculture, Chanthaburi Horticultural Research Center. A Voucher specimen number #10102 was assigned. The plant material was washed to remove contaminants and dried at 50 o C in a hot air oven for 24 h. The plant samples were separately pulverized in a blender and stored at room temperature, away from light. Dulbecco's Modified Eagle Medium (DMEM), fetal bovine serum (FBS), glutamine, penicillin, and streptomycin were purchased from Invitrogen (USA). MTT reagent (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide)

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“…The cytotoxicity of isolated compounds can be further compared with the standard drug such as doxorubicin which possessed high anticancer activity (IC50 0.47-8.03 µM). 23 Intens.…”

Section: Resultsmentioning

confidence: 99%

Comparative Chemical Composition and In-Vitro Cytotoxic Activity of Syzygium aromaticum against Selected Cancer Cell Lines

2021

TJNPR

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“…The literature search was performed using a previously reported method. [25][26][27][28] The selection of the original articles was of utmost importance because these papers have a direct impact on the findings and the final results. The present review contains all original articles registered with the target subject in the "All Databases" between 2017 and 2020.…”

Section: Literature Searchmentioning

confidence: 99%

“…The previous chemical investigations of N. tabacum indicated that 46 isolated compounds could be divided into nine categories: diterpenoids (1-6), sesquiterpenes (7-13), furan-2-carboxylic acids (14)(15)(16)(17)(18)(19)(20)(21)(22), flavonoids (23)(24)(25)(26)(27)(28)(29)(30)(31)(32), sterols (33-36), 2-arylbenzofurans (37,38), isobenzofurans (39-41), phenylpropanoids (42)(43)(44)(45), and aminoglucoside (46). Among them, terpenes and flavonoids were predominant (Figure 1).…”

Section: Chemical Constituentsmentioning

confidence: 99%

An Update on Chemical Constituents from Nicotiana tabacum L. and Their Bioactivities from 2017 to 2020

Xu¹,

Liu²,

Ni³

et al. 2020

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“…N , O -Acetal/ketal represent an important architecture in bioactive natural and pharmaceutical products [ 1 , 2 , 3 ]. Typical structures such as aspidosperma alkaloid (-)-aspidophytine [ 4 , 5 ], lycopodium alkaloid lycoplanine A [ 6 ], indoline alkaloid rosibiline [ 7 ], and macrocyclic marine alkaloid ‘upenamide [ 8 , 9 ] are shown in Figure 1 .…”

Section: Introductionmentioning

confidence: 99%

Silver Catalyzed Decarbonylative [3 + 2] Cycloaddition of Cyclobutenediones and Formamides

Wang

Ali

et al. 2021

Molecules

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As an important moiety in natural products, N,O-acetal has attracted wide attention in the past few years. An efficient method to construct N,O-acetal has been developed. Using silver catalyst, cyclobutenediones were smoothly converted to the corresponding γ-aminobutenolides in the presence of formamides, in which cyclobutenediones likely proceed with a key decarbonylative [3 + 2] cycloaddition process. In this way, a series of products with varied substituents were isolated in moderate yield and fully characterized.

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Newly reported alkaloids produced by marine-derived Penicillium species (covering 2014–2018)

Cited by 52 publications

References 75 publications

Comparative Chemical Composition and In-Vitro Cytotoxic Activity of Syzygium aromaticum against Selected Cancer Cell Lines

Comparative Chemical Composition and In-Vitro Cytotoxic Activity of Syzygium aromaticum against Selected Cancer Cell Lines

An Update on Chemical Constituents from Nicotiana tabacum L. and Their Bioactivities from 2017 to 2020

Silver Catalyzed Decarbonylative [3 + 2] Cycloaddition of Cyclobutenediones and Formamides

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