A globalisation-induced environmental consequence can either improve or degenerate the quality of life (QoL), depending on its interference in the balance between the demand and supply of ecological resources, and food security. Hence, this study examined the ecological burdens of globalisation on the QoL for 38 African countries between 1990 and 2020. Empirical inferences for the study were robustly deduced through advanced estimation methodologies. They include Driscoll-Kraay (D-K), augmented mean group (AMG) and the panel dynamic ordinary least squares (PDOLS) techniques. The study further applied the method of moments quantile regression (MMQREG) approach, since the economic progressions in each selected African country are heterogeneous despite their classification as developing nations. Notable findings from these methodologies revealed the ecological demand burden of globalisation to be diminishing the QoL. In contrast, the supply and food security effects of liberalisation are QoL enhancing. Specifically, the MMQREG procedure revealed that the adverse acceleration in the demand side of the consequence grows larger in magnitude when compared to the positive effects in the supply and food security sides as the quantile advances. The implication is that depending on the level of QoL, the ecological burden of liberalisation tends to worsen through the overexploitation and retardation of the regenerative process of natural resources, and the exacerbation of food insecurity in African countries. Applicable policy measures were proposed by the study.