NF-κB and Nrf2 pathways contribute to the protective effect of Licochalcone A on dextran sulphate sodium-induced ulcerative colitis in mice

Dongyu, Liu; Huo, Xiaowei; Gao, Li; Zhang, Juan; Ni, Hui; Cao, Li

doi:10.1016/j.biopha.2018.03.130

Cited by 73 publications

(47 citation statements)

References 30 publications

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“…Licochalcone A (Lico A) is a characteristic chalcone existing in licorice root, which is widely used in Chinese medicine formulae. The results show that Lico A (20, 40 and 80 mg/kg) treatment reduces the colon length, histological damage scores and MPO activity, and decreases the oxidative stress and pro-inflammatory cytokines, down-regulates NF-κB pathway and up-regulates Nrf2 pathway in DSS-induced UC [118]. Furthermore, as a substance extracted and purified from Glycyrrhiza uralensis Fisch, diammonium glycyrrhizinate (40 mg/kg) treatment is found to reduce inflammatory injury in a rat model of UC via suppressions of NF-κB and TNF-α in colonic mucosa [119].…”

Section: Tonifying Medicinementioning

confidence: 88%

“…Qi-regulating medicine Norisoboldine DSS-induced colon tissues Inhibit phosphorylation, nuclear translocation and DNA-binding activity of NF-κBp65 [113] Citrus aurantium L. TNBS-induced colon tissues Inhibit the NF-κB pathway [114] RAW264.7 cells Inhibit the protein expressions of NF-κB [114] Tonifying medicine Eclipta Prostrata HT-29 cells Reduce the nuclear translocation of NF-κB [115] Astragalus polysaccharide DSS-induced colonic tissues Reduce NF-κB DNA phosphorylation activity [116] Astragaloside IV CCD-18Co cells Inhibit the phosphorylation of NF-κBp65 [117] Licochalcone A DSS-induced colonic tissues Reverse the increased expression of p65 NF-κB [118] Diammonium glycyrrhizinate AA-induced colonic tissues Suppress the positive percentage and density of NF-κBp65 [119] Vanillic acid DSS-induced colon tissues Suppress the activation of transcription NF-κBp65 [120] Paeoniflorin TNBS-induced colon tissues Inhibit the expressions of p-NF-κB [121] The fruit of Ziziphus jujuba Mill.…”

Section: Chinese Medicines Models Mechanisms Referencesmentioning

confidence: 99%

“…Reverse the increased expression of IKKα and p-IκB [118] The fruit of Ziziphus jujuba Mill. AOM/DSS-induced colon tissue Attenuate inflammation, tumor development and progression by down-regulation of expression of STAT3 [122] Lentinus edodes β-glucans DSS-induced colon tissues Modify p38MAPK and ERK1/2, and then phosphorylating PPARγ, which negatively regulates activation of NF-κB [124] Mango polyphenolics…”

Section: Dss-induced Colonic Tissuesmentioning

confidence: 99%

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Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines

Zhao

2020

Chin Med

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Nuclear factor-kappa B (NF-κB) is a kind of multi-functional nuclear transcription factor involved in regulating gene transcription to influence pathological evolution of inflammatory and immune diseases. Numerous literature evidence that NF-κB pathway plays an essential role in pathogenic development of ulcerative colitis (UC). UC is a chronic non-specific inflammatory bowel disease, and until now, therapeutic agents for UC including aminosalicylates, corticosteroids and immune inhibitors still cannot exert satisfied effects on patients. In recent years, Chinese medicines suggest the advantages of alleviating symptoms and signs, decreasing side-effects and recurrence, whose one of mechanisms is related to regulation of NF-κB pathway. In this review, we categorize Chinese medicines according to their traditional therapeutic functions, and summarize the characteristics of Chinese medicines targeting NF-κB pathway in UC treatment. It indicates that 85 kinds of Chinese medicines' compounds and formulae can directly act on NF-κBp65; while 58 Chinese medicines' ingredients and formulae indirectly suppress NF-κBp65 by regulation of its upstream or other related pathways. Moreover, by the analysis of Chinese medicines' category based on their traditional functions, we conclude the category of dampness-drying and detoxificating medicine targeting NF-κB pathway accounts for primary status for amelioration of UC. Simultaneously, this review also contributes to the choices of Chinese medicine category and provides curative potential of Chinese medicines for clinical UC treatment.

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Section: Tonifying Medicinementioning

confidence: 88%

Section: Chinese Medicines Models Mechanisms Referencesmentioning

confidence: 99%

Section: Dss-induced Colonic Tissuesmentioning

confidence: 99%

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Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines

Zhao

2020

Chin Med

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“…MIP‐1α also induces the release of interleukin 1 (IL‐1), IL‐6, and tumor necrosis factor alpha proinflammatory cytokines . The role of oxidative stress in UC has been documented as chronic intestinal inflammation is associated with reactive oxygen and nitrogen species leading to oxidative and nitrosative stress . Hesperetin‐7 rutinoside (HES) is one of the flavonoids that constitutes citrus fruits and is found naturally as glycosides .…”

Section: Introductionmentioning

confidence: 99%

Hesperidin modulates dextran sulfate sodium‐induced ulcerative colitis in rats: Targeting sphingosine kinase‐1‐ sphingosine 1 phosphate signaling pathway, mitochondrial biogenesis, inflammation, and apoptosis

Shafik

Gaber

Mohamed

et al. 2019

J Biochem & Molecular Tox

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Ulcerative colitis (UC) is a chronic gastrointestinal disorder interfering with life quality. A total of 60 male Wistar rats were divided into four equal groups: Control (group I), hesperidin only (group II), UC untreated (group III), and UC treated with hesperidin (group IV). Hesperidin had modulatory effects on UC pathogenesis, which might be through alleviating colonic sphingosine phosphate phosphatase 2 messenger RNA expression and sphingosine kinase-1 levels, thus suppressing the subsequent downstream inflammatory and apoptotic cascades represented by decreased macrophage inflammatory protein-1α and enhancement of B-cell lymphoma 2 immunohistochemistry expression. Also, it improved mitochondrial biogenesis by increasing the peroxisome proliferator-activated receptor-gammacoactivator 1-α level. It successfully restored redox potential as evidenced by marked alleviations of the nitric oxide and peroxynitrite levels, increasing total antioxidant capacity, and activating the superoxide dismutase enzyme. Also, hesperidin alleviated the UC disease activity index and improved the histopathological picture. These findings may offer a new therapeutic strategy for UC treatment. K E Y W O R D S hesperidin, macrophage inflammatory protein-1 alpha, peroxisome proliferator-activated receptor-gamma-coactivator 1-α, sphingosine kinase, ulcerative colitis

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“…Licochalcone A, a characteristic chalcone isolated from licorice roots [36], was proved to be resistant to many types of cancer cells through different mechanisms. Induction of mitochondrial dysfunction is one of the main pathways leading to apoptosis by licochalcone A.…”

Section: Anticancer Activitymentioning

confidence: 99%

Natural Chalcones in Chinese Materia Medica: Licorice

Wang

Liang

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Licorice is an important Chinese materia medica frequently used in clinical practice, which contains more than 20 triterpenoids and 300 flavonoids. Chalcone, one of the major classes of flavonoid, has a variety of biological activities and is widely distributed in nature. To date, about 42 chalcones have been isolated and identified from licorice. These chalcones play a pivotal role when licorice exerts its pharmacological effects. According to the research reports, these compounds have a wide range of biological activities, containing anticancer, anti-inflammatory, antimicrobial, antioxidative, antiviral, antidiabetic, antidepressive, hepatoprotective activities, and so on. This review aims to summarize structures and biological activities of chalcones from licorice. We hope that this work can provide a theoretical basis for the further studies of chalcones from licorice.

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NF-κB and Nrf2 pathways contribute to the protective effect of Licochalcone A on dextran sulphate sodium-induced ulcerative colitis in mice

Cited by 73 publications

References 30 publications

Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines

Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines

Hesperidin modulates dextran sulfate sodium‐induced ulcerative colitis in rats: Targeting sphingosine kinase‐1‐ sphingosine 1 phosphate signaling pathway, mitochondrial biogenesis, inflammation, and apoptosis

Natural Chalcones in Chinese Materia Medica: Licorice

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