Abstract:Knee osteoarthrosis (OA) is a multifactorial disease with genetic factors playing an important part in its development. Our research goal was to examine associations between polymorphic variants rs1060105 and rs56116847 of SBNO1 gene, rs6499244 of NFAT5 gene and rs34195470 of WWP2 gene and developing stage 4 knee osteoarthrosis in people living in the Central Chernozem Region in Russia. Genotyping of polymorphic loci of candidate genes was accomplished in 95 patients with stage 4 knew osteoarthrosis and 500 pe… Show more
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