NGAL as a marker for some extrarenal complications in acute coronary syndrome

Шаленкова, М А; Михайлова, З Д; Климкин, П Ф

doi:10.18087/cardio.2416

Cited by 4 publications

(4 citation statements)

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“…In agreement with these results, NGAL was also found to be elevated in aldosterone-induced cardiac injuries, and the inhibition of NGAL led to anti-inflammatory and anti-fibrotic effects 97 . Moreover, clinical research has revealed the possibility of the use of NGAL as a supplementary marker for cardiovascular conditions 98 . Surprisingly, a recently published study announced the potential cardioprotective roles of neutrophils in cardiac healing, as evidenced by the excessive fibrosis, increased levels of markers for HF, and worsening cardiac function in neutrophil-depleted mice; mechanistically, abundant neutrophils are required to recruit monocytes and promote macrophage polarization into the M2 reparative phenotype, which mainly occurs through the induction of NGAL 99 .…”

Section: Immune Cellsmentioning

confidence: 99%

The Roles of Noncardiomyocytes in Cardiac Remodeling

Yang

Liu

et al. 2020

Int. J. Biol. Sci.

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Cardiac remodeling is a common characteristic of almost all forms of heart disease, including cardiac infarction, valvular diseases, hypertension, arrhythmia, dilated cardiomyopathy and other conditions. It is not merely a simple outcome induced by an increase in the workload of cardiomyocytes (CMs). The remodeling process is accompanied by abnormalities of cardiac structure as well as disturbance of cardiac function, and emerging evidence suggests that a wide range of cells in the heart participate in the initiation and development of cardiac remodeling. Other than CMs, there are numerous noncardiomyocytes (non-CMs) that regulate the process of cardiac remodeling, such as cardiac fibroblasts and immune cells (including macrophages, lymphocytes, neutrophils, and mast cells). In this review, we summarize recent knowledge regarding the definition and significant effects of various non-CMs in the pathogenesis of cardiac remodeling, with a particular emphasis on the involved signaling mechanisms. In addition, we discuss the properties of non-CMs, which serve as targets of many cardiovascular drugs that reduce adverse cardiac remodeling.

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Section: Immune Cellsmentioning

confidence: 99%

The Roles of Noncardiomyocytes in Cardiac Remodeling

Yang

Liu

et al. 2020

Int. J. Biol. Sci.

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“…Широкий ряд научных работ посвящен изучению роли GDF-15 как фактора риска смерти от всех причин [2], а также в зависимости от возраста больного [6], наличия сердечной недостаточности [7], различных форм ИБС [8,9], фибрилляции предсердий [3], легочной и системной артериальной гипертензии [10,11], сахарного диабета и ожирения [12], воспалительных процессов [13], поражения почек [14], онкологических заболеваний с оценкой эффективности противоопухолевой терапии и развитием кардиотоксичности [15] и т.д.…”

Section: Introductionunclassified

Interrelation of growth/differentiation factor-15 level with laboratory and clinical and functional parameters of patients with coronary artery disease

Zakharyan

2023

Cardiovasc Ther Prev

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Growth differentiation factor 15 (GDF-15) is a circulating protein that is associated with various pathological conditions.Aim. To study the relationship between the level of GDF-15 and laboratory, clinical and functional parameters of patients with coronary artery disease (CAD).Material and methods. All patients with coronary artery disease underwent a general clinical examination, coronary angiography, extracranial artery ultrasound examination, echocardiography, determination of the serum level of GDF-15 (ng/ml) and matrix metalloproteinase 9 (ng/ml). Statistical processing of the obtained results was carried out using the Statistica 10.0 software.Results. The study included 88 people (55 men and 33 women), 78 of whom were patients with an established diagnosis of CAD and 10 were healthy volunteers (control group). In the group of CAD patients, the median level of GDF-15 was 4,98 ng/ml [3,15; 8,24], while in the control group — 1,95 ng/ml [0,01; 2,45]. An association of GDF-15 concentration with the age of patients was found (r=0,44; p<0,001). There was a direct correlation between the level of GDF-15 and interventricular septal thickness (r=0,33; p<0,05), heart failure stage (Strazhesko-Vasilenko classification) (r=0,23; p<0,05), the concentration of matrix metalloproteinase 9 (r=0,24; p<0,05), carotid intima-media thickness (r=0,28; p<0,05), the number of coronary arteries that required revascularization during coronary artery bypass grafting (r=0,52; p<0,05), and multifocal atherosclerosis (r=0,23; p<0,05). In patients with atherosclerotic lesions in 2 or 3 vascular beds, the level of GDF-15 was significantly higher than in patients with CAD (p<0,05).Conclusion. The results obtained demonstrate the value of GDF-15 as a potential marker of atherosclerotic vascular changes, the severity of myocardial hypertrophy, and the severity of heart failure.

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“…As a member of the lipocalin family, NGAL participates in the transportation of lipophilic substances. Additionally, it has also been reported that NGAL is associated with the delivery of iron from the extracellular space into the inner cell, which may promote tumor development and support the proliferation of neoplastic cells[ 16 , 17 ]. Previous studies revealed that increased expression of NGAL contributed to the progression of cancers[ 18 , 19 ], and in a number of malignancies, NGAL was over-expressed[ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Combination of neutrophil gelatinase-associated lipocalin and matrix metalloproteinase-9 are biomarkers for the detection of colon tubular adenocarcinoma

Yuan¹,

Xie²,

Zhu³

et al. 2021

WJGO

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BACKGROUND Tubular adenocarcinoma of the colon, which originates from the epithelium of the glands, is a major health concern worldwide. However, it is difficult to detect at an early stage. The lack of biomarkers is a main barrier to the diagnosis and treatment of tubular adenocarcinoma. Neutrophil gelatinase-associated lipocalin (NGAL) is a secreted protein that induces the expression of matrix metalloproteinase-9 (MMP-9) and is involved in various tumors. NGAL and MMP-9 have been reported to be associated with tumorigenesis and development. They may have potential as biomarkers for diagnosis of tubular adenocarcinoma of the colon. AIM To determine whether NGAL and MMP-9 can be used as potential biomarkers to indicate the progression of tubular adenocarcinoma of the colon. METHODS Samples were collected from surgically excised tissue from various patients. The content of pro-gastrin-releasing peptide (pro-GRP) in the serum was measured by an electrochemiluminescence immunoassay. The expression patterns of NGAL and MMP-9 and the relationship between NGAL and MMP-9 were examined by quantitative real-time PCR, Western blotting and immunohistochemical analysis. RESULTS In this study, we found that NGAL and MMP-9 can be used as biomarkers for the detection of tubular adenocarcinoma of the colon and that their combination improved diagnostic accuracy. By analyzing the expression of NGAL in tubular adenocarcinoma at different levels, we found that NGAL expression was significantly upregulated in primary tubular adenocarcinoma tissues compared with normal tissues. The upregulation of NGAL expression was strongly correlated with both the degree of differentiation and the disease stage (I–III), indicating that NGAL could serve as a diagnostic biomarker for tubular adenocarcinoma. When using NGAL as a biomarker for diagnosis, the accuracy was similar to that achieved with the widely used biomarker pro-GRP, suggesting that NGAL is reliable. Moreover, the expression of MMP-9 was also strongly correlated with the differentiation stage, demonstrating that MMP-9 could be used as a biomarker to indicate the progression of tubular adenocarcinoma of the colon. More importantly, the combination of NGAL and MMP-9 produced a more accurate diagnosis of tubular adenocarcinoma, and these results were further confirmed by immunohistochemical analysis of tissue sections. CONCLUSION Our study demonstrated that both NGAL and MMP-9 can be used as biomarkers for the diagnosis of colon tubular adenocarcinoma and that the results could be further improved by combining them.

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NGAL as a marker for some extrarenal complications in acute coronary syndrome

Cited by 4 publications

References 0 publications

The Roles of Noncardiomyocytes in Cardiac Remodeling

The Roles of Noncardiomyocytes in Cardiac Remodeling

Interrelation of growth/differentiation factor-15 level with laboratory and clinical and functional parameters of patients with coronary artery disease

Combination of neutrophil gelatinase-associated lipocalin and matrix metalloproteinase-9 are biomarkers for the detection of colon tubular adenocarcinoma

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