Nickel ferrite nanoparticles: an efficient and reusable nanocatalyst for a neat, one-pot and four-component synthesis of pyrroles

Abstract

Rezvani• We applied magnetics NiFe 2 O 4 as a recoverable catalyst in the multicomponent reaction of substituted pyrroles • Magnetic NiFe 2 O 4 could be recovered from the reaction easily with an external magnet and be used nine times without significant activity loss. •The catalytic activity of magnetic NiFe 2 O 4 nanoparticles were less studied in organic reactions. • The reaction conditions is mild and the process of catalyst preparation is simple.• The yields are high.In this study nickel ferrite magnetic nanoparticles were applied as an efficient and reusable catalyst in the four-component synthesis of substituted pyrroles under neat conditions. The reaction was conducted using various amounts of catalyst at different temperatures and finally, application of 5 mol% of catalyst at 100°C was determined as the optimum reaction conditions. Results showed that nickel ferrite nanoparticles could catalyze the reaction at relatively short times (3-4 h) with high to excellent yields (70-96%). The catalyst could be recovered easily using an external magnetic field and be reused for nine times without any significant activity lost.

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