Nickel(II)-Schiff base complex recognizing domain II of bovine and human serum albumin: Spectroscopic and docking studies

Biophysical study on the interaction between two palladium(II) complexes and human serum albumin by Multispectroscopic methods

“…This data confirms that the quenching mechanism involves the static diffusion process [24]. Similar results were obtained for interaction between HSA and other metal complexes [25][26][27].…”

“…Therefore, the negative enthalpy and entropy values of the interactions indicate that the hydrogen bonding and van der Waals forces play major roles in the binding of HSA with Pd(II) complexes. In addition, the negative sign for ΔH°indicates that the formation of the HSA-Pd(II) complexes was exothermic [27]. The negative values of ΔG°support the assertion that the binding process is a spontaneous intermolecular reaction (Table 3) [24].…”

A mononuclear Cu(II) complex with 5,6-diphenyl-3-(2-pyridyl)-1,2,4-triazine: Synthesis, crystal structure, DNA- and BSA-binding, molecular modeling, and anticancer activity against MCF-7, A-549, and HT-29 cell lines

“…So, in order to calculate the binding constants for the quencher-acceptor system, three different analyses approaches have been considered: i) Modified Stern-Volmer analysis, ii) Lineweaver-Burk analysis, and iii) Scatchard analysis [69]. In the present work, the binding constant (K bin ) was calculaed using Lineweaver-Burk analysis for λ ex = 280 nm, and modified Stern-Volmer analysis and Lineweaver-Burk analysis for λ ex = 295 nm.…”

In vitro DNA and BSA-binding, cell imaging and anticancer activity against human carcinoma cell lines of mixed ligand copper(II) complexes

“…Fluorescence spectroscopy is one of the effective methods in detecting the quenching mechanism, mode and strength of interaction BSA with compounds [45]. The strong fluorescence properties of BSA are due to the aromatic amino acids, tyrosine and tryptophan.…”

“…The type of mechanism of quenching (static quenching or dynamic quenching) can be distinguished from the nature of the Stern-Volmer plot and dependence of K SV on temperature [45,46]. Linear Stern-Volmer plot represent a single quenching mechanism, either static or dynamic.…”