Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice

Matsuda, Hiroki; Nibe-Shirakihara, Yoichi; Tamura, Akiko; Aonuma, Emi; Arakawa, Satoko; Otsubo, Kana; Nemoto, Yasuhiro; Nagaishi, Takashi; Tsuchiya, Kiichiro; Shimizu, Shigeomi; Ma, Averil; Watanabe, Mamoru; Uo, Motohiro; Okamoto, Ryuichi

doi:10.1016/j.bbrc.2021.12.111

Cited by 10 publications

(5 citation statements)

References 21 publications

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“…Using a novel method of Synchrotron radiation-induced X-ray fluorescence spectroscopy and X-ray absorption fine-structure analysis, a surprisingly high concentration of nickel particles was identified in the submucosa of tissues affected by CD. No other metallic elements were detected alongside nickel [135].…”

Section: Nickel and Ibdmentioning

confidence: 89%

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Adverse Food Reactions in Inflammatory Bowel Disease: State of the Art and Future Perspectives

Capobianco,

Di Vincenzo,

Puca

et al. 2024

Nutrients

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Limited knowledge is available about the relationship between food allergies or intolerances and inflammatory bowel disease (IBD). Clinicians frequently encounter patients who report food allergies or intolerances, and gastroenterologists struggle distinguishing between patients with organic disorders and those with functional disorders, which the patients themselves may associate with specific dietary components. This task becomes even more arduous when managing patients with significant underlying organic conditions, like IBD. The aim of this review is to summarize and emphasize any actual associations between food allergies and intolerances and inflammatory diseases, such as ulcerative colitis and Crohn’s disease. Through a narrative disceptation of the current literature, we highlight the increased prevalence of various food intolerances, including lactose, fructose, histamine, nickel, and non-celiac gluten sensitivity, in individuals with IBD. Additionally, we explore the association between increased epithelial barrier permeability in IBD and the development of food sensitization. By doing so, we aim to enhance clinicians’ awareness of the nutritional management of patients with IBD when facing complaints or evidence of food allergies or intolerances.

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Section: Nickel and Ibdmentioning

confidence: 89%

“…Even more astonishing was the finding that nickel particles induced colitis in mice carrying mutations of the IBD susceptibility protein A20/TNFAIP3. Additionally, nickel particles exacerbated dextran sulfate sodium-induced colitis in mice with myeloid cellspecific Atg5 deficiency [135].…”

Section: Nickel and Ibdmentioning

confidence: 99%

Adverse Food Reactions in Inflammatory Bowel Disease: State of the Art and Future Perspectives

Capobianco,

Di Vincenzo,

Puca

et al. 2024

Nutrients

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“…Hexavalent chromium (Cr VI) is reduced to trivalent chromium (Cr III) by a biochemical process that occurs after absorption into the body; chromium reduction leads to DNA damage causing histological damage [11]. A common pathology is skin hypersensitivity, caused by a nickel (Ni) allergy that causes dermatitis [12]. Aluminum (Al) causes numerous diseases, such as Alzheimer's disease and pulmonary fibrosis, and generates acute neurotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Quantification of Heavy Metal Content in Anadara tuberculosa from the Gulf of Guayaquil Using ICP-OES: Assessing Marine Contamination

Vinces,

Pacheco Flores de Valgaz,

Ballesteros

2024

Applied Sciences

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The present study was conducted to quantify the heavy metals cadmium, lead, copper, chromium, nickel, and zinc in the bivalve mollusk concha prieta (Anadara tuberculosa) using inductively coupled plasma optical emission spectroscopy (ICP-OES). This research aims to identify whether the bioaccumulated content of heavy metals exceeds the maximum limits established by various public health bodies such as the ONU, FAO, Codex Alimentarius, EEC, and NHI. Samples of the species were collected randomly from three locations in Puerto El Morro, Playas Municipal Market, and La Libertad Seafood Market in the Gulf of Guayaquil. Thirty-three soft tissue samples of Anadara tuberculosa were evaluated, and the values quantified in mg/kg were in the following order: Zn > Cu > Cd > Ni > Cr > Pb.

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“…Other sources of nickel in the environment are combustion of fossil fuels, generation of electricity, mining, and the cement industry [ 21 , 22 ]. This heavy metal exacerbates symptoms of Crohn’s disease [ 23 ]. Exposure to nickel is also implicated in asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and neoplastic lesions [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Mitigation of the Adverse Impact of Copper, Nickel, and Zinc on Soil Microorganisms and Enzymes by Mineral Sorbents

et al. 2022

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Despite numerous studies on the influence of heavy metals on soil health, the search for effective, eco-friendly, and economically viable remediation substances is far from over. This encouraged us to carry out a study under strictly controlled conditions to test the effects of Cu2+, Ni2+, and Zn2+ added to soil in amounts of 150 mg·kg−1 d.m. of soil on the soil microbiome, on the activity of two oxidoreductases and five hydrolases, and on the growth and development of the sunflower Helianthus annunus L. The remediation substances were a molecular sieve, halloysite, sepiolite, expanded clay, zeolite, and biochar. It has been demonstrated that the most severe turbulences in the soil microbiome, its activity, and the growth of Helianthus annunus L. were caused by Ni2+, followed by Cu2+, and the mildest negative effect was produced by Zn2+. The adverse impact of heavy metals on the soil microbiome and its activity was alleviated by the applied sorbents. Their application also contributed to the increased biomass of plants, which is significant for the successful phytoextraction of these metals from soil. Irrespective of which property was analysed, sepiolite can be recommended for the remediation of soil polluted with Ni2+ and zeolite—for soil polluted with Cu2+ and Zn2+. Both sorbents mitigated to the highest degree disturbances caused by the tested metals in the soil environment.

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Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice

Cited by 10 publications

References 21 publications

Adverse Food Reactions in Inflammatory Bowel Disease: State of the Art and Future Perspectives

Adverse Food Reactions in Inflammatory Bowel Disease: State of the Art and Future Perspectives

Quantification of Heavy Metal Content in Anadara tuberculosa from the Gulf of Guayaquil Using ICP-OES: Assessing Marine Contamination

Mitigation of the Adverse Impact of Copper, Nickel, and Zinc on Soil Microorganisms and Enzymes by Mineral Sorbents

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