Nickel Sensitivity Is Associated with GH-IGF1 Axis Impairment and Pituitary Abnormalities on MRI in Overweight and Obese Subjects

Risi, Renata; Masieri, Simonetta; Poggiogalle, Eleonora; Watanabe, Mikiko; Caputi, Alessandra; Tozzi, Rossella; Gangitano, Elena; Masi, Davide; Mariani, Stefania; Gnessi, Lucio; Lubrano, Carla

doi:10.3390/ijms21249733

Cited by 13 publications

(9 citation statements)

References 73 publications

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“…It was postulated that sex hormones exert a proinflammatory effect to recruit eosinophils into the conjunctiva, thus leading to the development of VKC [ 2 ]. Regarding the involvement of GH on allergic inflammation, it was reported that GHD was diagnosed in four (16%) patients out of 25 in nonallergic group and in 13 (30.9%) patients out of 42 in nickel-allergic group [ 4 ]. Thus, GHD may play a role, at least in part, in the development of allergic inflammation, such as VKC.…”

Section: Discussionmentioning

confidence: 99%

A Case of Vernal Keratoconjunctivitis With Growth Hormone Deficiency

Fukushima¹,

Tabuchi²

2022

Cureus

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Hormonal abnormalities are considered to play a role in the development of vernal keratoconjunctivitis (VKC). However, little is known whether about growth hormone (GH) is related to VKC development. The patient was an 11-year-old male with VKC treated with 0.1% betamethasone eye drops and 0.1% cyclosporin eye drops. The papillary growth of both superior and inferior palpebral conjunctiva worsened, and masses started to appear at the lower palpebral margin. He was referred to our hospital and was treated with 0.1% tacrolimus and 0.1% fluorometholone. Six weeks later, the condition improved remarkably. At this timepoint, we noticed the patient's short stature and asked again about his past history. Two years ago, he was diagnosed with GH deficiency (GHD), which had been treated with somatropin in a pediatric clinic. Thus, it is necessary to keep in mind the possibility of GHD when treating VKC patients.

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Section: Discussionmentioning

confidence: 99%

A Case of Vernal Keratoconjunctivitis With Growth Hormone Deficiency

Fukushima¹,

Tabuchi²

2022

Cureus

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“…Participants for this study were recruited among those who referred to the High Specialization Centre for the Care of Obesity (CASCO), in Umberto I Polyclinic, Sapienza University of Rome, between 2014 and 2019. Some patients were also included in other studies already published by our group [ 6 , 7 ].…”

Section: Methodsmentioning

confidence: 99%

Growth Hormone Secretory Capacity Is Associated with Cardiac Morphology and Function in Overweight and Obese Patients: A Controlled, Cross-Sectional Study

Gangitano

Bárbaro

Susi

et al. 2022

Cells

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Obesity is associated with increased cardiovascular morbidity. Adult patients with growth hormone deficiency (GHD) show morpho-functional cardiological alterations. A total of 353 overweight/obese patients are enrolled in the period between 2009 and 2019 to assess the relationships between GH secretory capacity and the metabolic phenotype, cardiovascular risk factors, body composition and cardiac echocardiographic parameters. All patients underwent GHRH + arginine test to evaluate GH secretory capacity, DEXA for body composition assessment and transthoracic echocardiography. Blood samples are also collected for the evaluation of metabolic parameters. In total, 144 patients had GH deficiency and 209 patients had normal GH secretion. In comparing the two groups, we found significant differences in body fat distribution with predominantly visceral adipose tissue accumulation in GHD patients. Metabolic syndrome is more prevalent in the GHD group. In particular, fasting glycemia, triglycerides and systolic and diastolic blood pressure are found to be linearly correlated with GH secretory capacity. Epicardial fat thickness, E/A ratio and indexed ventricular mass are worse in the GHD group. In the population studied, metabolic phenotype, body composition, cardiovascular risk factors and cardiac morphology are found to be related to the GH secretory capacity. GH secretion in the obese patient seems to be an important determinant of metabolic health.

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“…Ni exposure leads to abnormal production/release of growth hormone (GH). In addition, Ni-allergic patients show GH-insulin-like growth factor 1 (IGF1) axis impairment, probably by increasing the inflammation in the pituitary gland [ 27 ].…”

Section: Exposurementioning

confidence: 99%

Metal Allergy: State-of-the-Art Mechanisms, Biomarkers, Hypersensitivity to Implants

Zemelka‐Wiącek¹

2022

JCM

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Metal allergy is mainly an environmental disorder which can cause allergic contact dermatitis. Environmental metal exposures include jewelry, everyday metal items, mobile phones, leather, metal-rich food and implants, including stents or anchors. While consumer exposure is liable for the majority of metal hypersensitivity cases, the significance of occupational exposure to metals remains relevant. Although the most common metal allergens are nickel, chromium, and cobalt; however, lately, gold, palladium, titanium, and some others have also attracted attention. This review highlights advances in metal allergy mechanisms, biomarkers for potential patients’ stratification as well as biological treatments. The most recent evidence of human exposure to metal for risk assessment is discussed, as well as the relationship between the occurrence of metal hypersensitivity and implanted devices, including non-characteristic symptoms. The latest data on the diagnosis of metal hypersensitivity are also reported.

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Nickel Sensitivity Is Associated with GH-IGF1 Axis Impairment and Pituitary Abnormalities on MRI in Overweight and Obese Subjects

Cited by 13 publications

References 73 publications

A Case of Vernal Keratoconjunctivitis With Growth Hormone Deficiency

A Case of Vernal Keratoconjunctivitis With Growth Hormone Deficiency

Growth Hormone Secretory Capacity Is Associated with Cardiac Morphology and Function in Overweight and Obese Patients: A Controlled, Cross-Sectional Study

Metal Allergy: State-of-the-Art Mechanisms, Biomarkers, Hypersensitivity to Implants

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