2021
DOI: 10.21203/rs.3.rs-138253/v1
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Niclosamide Targets Inflammatory and Profibrotic Pathways in Amyotrophic Lateral Sclerosis

Abstract: BackgroundAn increasing number of studies evidence that amyotrophic lateral sclerosis (ALS) is characterized by extensive alterations in different cell types and in different regions besides the CNS. We previously reported the up-regulation in ALS models of a gene called fibroblast-specific protein (FSP)-1 or S100A4, generally recognized as a pro-inflammatory and profibrotic factor. Since inflammation and fibrosis are often mutual-sustaining events that contribute to establish a hostile environment for organ f… Show more

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“…Like in PF, S100A4, as a downstream mediator of the stimulatory effects of TGF-β1, amplifies TGF-β1-induced fibroblasts activation in systemic sclerosis (Tomcik et al, 2015). Silencing S100A4 with siRNA or blocking S100A4 with niclosamide inhibited fibroblasts activation in amyotrophic lateral sclerosis (Milani et al, 2021). S100A4 released from highly bone-metastatic breast cancer cells plays a critical role in osteolysis (Kim et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
“…Like in PF, S100A4, as a downstream mediator of the stimulatory effects of TGF-β1, amplifies TGF-β1-induced fibroblasts activation in systemic sclerosis (Tomcik et al, 2015). Silencing S100A4 with siRNA or blocking S100A4 with niclosamide inhibited fibroblasts activation in amyotrophic lateral sclerosis (Milani et al, 2021). S100A4 released from highly bone-metastatic breast cancer cells plays a critical role in osteolysis (Kim et al, 2019).…”
Section: Discussionmentioning
confidence: 99%