2007
DOI: 10.1016/j.bcp.2006.11.024
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Nicotinamide inhibits B lymphocyte activation by disrupting MAPK signal transduction

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Cited by 18 publications
(11 citation statements)
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“…Nicotinamide has been shown to downregulate NF-kB activity in another model based on the UV stimulation of transfected HaCaT cells [38]. Our findings are also consistent with reports of the inhibition of ERK phosphorylation by nicotinamide in B lymphocytes stimulated with anti-IgM [39].…”
Section: Discussionsupporting
confidence: 94%
“…Nicotinamide has been shown to downregulate NF-kB activity in another model based on the UV stimulation of transfected HaCaT cells [38]. Our findings are also consistent with reports of the inhibition of ERK phosphorylation by nicotinamide in B lymphocytes stimulated with anti-IgM [39].…”
Section: Discussionsupporting
confidence: 94%
“…For example, it has been shown that NA is a potent inhibitor of pro-inflammatory cytokines produced by cells of the innate immune system [ 20 ]. Moreover, it has been shown that NA, but not MNA, inhibits cytokine synthesis, especially the synthesis of TNF-α [ 5 , 8 , 15 ]. Collectively, all these observations clearly indicate that the anti-inflammatory properties of NA are related to its ability to down-regulate functions of the cells of the immune system.…”
Section: Discussionmentioning
confidence: 99%
“…B cells were isolated from spleen by depletion of non-B cells and cultured as described (35). Activation conditions were as follows: 10 g/ml of F(abЈ) 2 anti-IgM (Jackson Immunoresearch, West Grove, PA) and/or with 6 g/ml of anti-CD40 (eBioscience, San Diego, CA) or 100 ng/ml of recombinant BAFF (R & D Systems, Minneapolis, MN) or with 100 ng/ml of LPS.…”
Section: Methodsmentioning
confidence: 99%