Nicotinamide Metabolites

Rutkowski, Bolesław; Rutkowski, Przemysław

doi:10.1002/9781118424032.ch11

Cited by 4 publications

(7 citation statements)

References 42 publications

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“…1 The endoplasmic reticulum (ER) stress response is frequently hyperactivated in cancer due to an accumulation of unfolded proteins, hypoxic conditions, calcium imbalance, and other stimuli. [2][3][4][5] Of note, the ER stress response can also be activated in response to the overexpression of oncogenes. [6][7] The three branches of ER stress response are governed by the stress sensor proteins IRE-1, ATF6, and PERK.…”

Section: Introductionmentioning

confidence: 99%

Structural Tailoring of a Novel Fluorescent IRE-1 RNase Inhibitor to Precisely Control Its Activity

et al. 2019

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Activation of the IRE-1/XBP-1 pathway has been linked to many human diseases. We report a novel fluorescent tricyclic chromenone inhibitor, D-F07, in which we incorporated a 9-methoxy group onto the chromenone core to enhance its potency and masked the aldehyde to achieve longterm efficacy. Protection of the aldehyde as a 1,3-dioxane acetal led to strong fluorescence emitted by the coumarin chromophore, enabling D-F07 to be tracked inside the cell. We installed a photolabile structural cage on the hydroxy group of D-F07 to generate PC-D-F07. Such a modification significantly stabilized the 1,3-dioxane acetal protecting group, allowing for specific stimulusmediated control of inhibitory activity. Upon photo-activation, the re-exposed hydroxy group on D-F07 triggered the aldehyde-protecting 1,3-dioxane acetal to slowly decompose, leading to the inhibition of the RNase activity of IRE-1. Our novel findings will also allow for spatiotemporal control of the inhibitory effect of other salicylaldehyde-based compounds currently in development.

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Section: Introductionmentioning

confidence: 99%

Structural Tailoring of a Novel Fluorescent IRE-1 RNase Inhibitor to Precisely Control Its Activity

et al. 2019

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“…The specimen consisted of cubic phase and had an average grain size of 4.6 μm and a relative density of 97.4%. 16 Four platinum electrodes were applied onto the surface of the specimen for the conductivity measurement. The specimen with the electrodes was placed on a stage inside of a tubular furnace of a mechanical testing machine (Shimadzu, AGS-H), and a preload of 10 N (i.e., 1.6 MPa of compressive stress in the current case) was applied.…”

Section: Methodsmentioning

confidence: 99%

“…The maximum loads were approximately 700 N for 293 K, 350 N at 473, 673, and 873 K, and 500 N at 1073 K (i.e., 110, 57, and 81 MPa, respectively), which were determined based on preliminary compressive tests and also reported fracture stress values at each temperature. 16,17 The load was continuously measured during the test, and the applied stress was calculated. The detail of mechanical behavior of BSCF under uniaxial compression such as stress -strain curves can be found in our previous report.…”

Section: Methodsmentioning

confidence: 99%

Electrical Conductivity of Ba_0.5Sr_0.5Co_0.8Fe_0.2O_3−δunder Uniaxial Compression at Elevated Temperatures

Araki

Takemura

Arai

et al. 2014

J. Electrochem. Soc.

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The present study reports on the electrical conductivity of Ba 0.5 Sr 0.5 Co 0.8 Fe 0.2 O 3−δ (BSCF) under compressing loadings at elevated temperatures. A compressive stress of up to 110 MPa was applied at elevated temperatures up to 1073 K. The experimental results clearly demonstrate the piezo-resistive/conductive characteristic of BSCF. The conductivity increases during the compressing loading, whilst it decreases during the unloading. The conductivity is linearly correlated to the applied stress. The average variation in the conductivity with 50 MPa of the stress is smallest (∼0.9%) at 293 K, whilst it is relatively higher (1.2-1.5%) at 473-873 K. The variation (1-1.2%) at 1073 K could be also related to a high-temperature creep deformation. The estimated geometric effect is quite small; thus, the increase in the conductivity could mostly be attributed to the piezo-resistive/conductive effect related to the lattice strain. The piezo-resistive/conductive parameters, π-factor and gauge factor, calculated are 15-26 × 10 −11 Pa −1 and 8-12, respectively, which are higher than those of LSCF. The present result also indicates a possibility to use BSCF as a stress/strain sensor at elevated temperatures.) unless CC License in place (see abstract). ecsdl.org/site/terms_use address. Redistribution subject to ECS terms of use (see 128.114.163.7 Downloaded on 2014-09-05 to IP ) unless CC License in place (see abstract). ecsdl.org/site/terms_use address. Redistribution subject to ECS terms of use (see 128.114.163.7 Downloaded on 2014-09-05 to IP ) unless CC License in place (see abstract). ecsdl.org/site/terms_use address. Redistribution subject to ECS terms of use (see 128.114.163.7 Downloaded on 2014-09-05 to IP

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“…The ideas mentioned above seem so basic that they should not raise any doubts. However, it is possible to notice the reluctance of a large number of professionals toward the participatory and pro-social nature of some architecture-related research [12].The results mentioned at the beginning [1] and the authors' other data collected during eye-tracking tests regarding anastylosis, looking at museum interiors, and the perception of depth in churches [13][14][15] suggest that such research should not be treated as a fad or a scientific whim [16], but rather a necessary act of cleansing the didactic contents included in the syllabuses of various architecture faculties from theories constructed on the basis of sheer intuition. Other scholars have also noticed the discrepancies in this respect [17].…”

Section: The Need To Verify Viewsmentioning

confidence: 99%

The Potential of Using an Eye Tracker in Architectural Education: Three Perspectives for Ordinary Users, Students and Lecturers

Rusnak

Rabiega

2021

Buildings

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The aim of this paper is to discuss the potential of eye trackers as tools providing diversified support for the architectural education of future designers. The possibility to track eye movement guaranteed by this group of devices enables an extension of knowledge on the non-professional perception of architectural creations. It also allows people to monitor progress while learning and verify a project’s assumptions as well as provide lecturers with an opportunity to optimize didactic methods. The paper includes authors’ ideas for modifications of teaching methods applied at technical universities. It is a result of an analysis of research related to the perception of urban designs and architectural objects—research during which noticeable differences were observed between how experts and non-professionals perceive these structures. What also contributed to the contents of this paper was a comprehension of the wide range of eye tracking studies examining the level of acquisition of specialist professional skills. The presented ideas are also based on the analysis and adaptation of eye-tracking research conducted by scientists within other areas of life.

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Nicotinamide Metabolites

Cited by 4 publications

References 42 publications

Structural Tailoring of a Novel Fluorescent IRE-1 RNase Inhibitor to Precisely Control Its Activity

Structural Tailoring of a Novel Fluorescent IRE-1 RNase Inhibitor to Precisely Control Its Activity

Electrical Conductivity of Ba_0.5Sr_0.5Co_0.8Fe_0.2O_3−δunder Uniaxial Compression at Elevated Temperatures

The Potential of Using an Eye Tracker in Architectural Education: Three Perspectives for Ordinary Users, Students and Lecturers

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Nicotinamide Metabolites

Cited by 4 publications

References 42 publications

Structural Tailoring of a Novel Fluorescent IRE-1 RNase Inhibitor to Precisely Control Its Activity

Structural Tailoring of a Novel Fluorescent IRE-1 RNase Inhibitor to Precisely Control Its Activity

Electrical Conductivity of Ba0.5Sr0.5Co0.8Fe0.2O3−δunder Uniaxial Compression at Elevated Temperatures

The Potential of Using an Eye Tracker in Architectural Education: Three Perspectives for Ordinary Users, Students and Lecturers

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Product

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Electrical Conductivity of Ba_0.5Sr_0.5Co_0.8Fe_0.2O_3−δunder Uniaxial Compression at Elevated Temperatures