Nicotine and Its Effect on Wound Healing

Mosely, Linda H.; Finseth, Frederick; Goody, Margaret

doi:10.1097/00006534-197804000-00013

Cited by 170 publications

(74 citation statements)

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“…A recent metaanalysis suggests that smoking is related to an increased incidence of fatal injuries [Leistikow et al, 1998], thereby corroborating the evidence linking cigarette smoking with both acute injuries [Sacks and Nelson, 1994;Kwiatkowski et al, 1996] and musculoskeletal disorders [Reynolds et al, 1994[Reynolds et al, , 1999Dettori et al, 1996]. However, the role of smoking in the development of physical disability following a musculoskeletal injury or disorder has been virtually unrecognized despite longstanding laboratory studies [Mosely et al, 1978;Siana et al, 1989] and recent clinical reviews [Towler, 2000;Krueger and Rohrich, 2001] demonstrating mechanisms and clinical evidence that smoking impairs wound healing.…”

Section: Introductionmentioning

confidence: 85%

The effect of cigarette smoking on musculoskeletal‐related disability

Lincoln

Smith

Amoroso

et al. 2003

American J Industrial Med

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Section: Introductionmentioning

confidence: 85%

The effect of cigarette smoking on musculoskeletal‐related disability

Lincoln

Smith

Amoroso

et al. 2003

American J Industrial Med

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“…The delayed wound healing observed in the group exposed to nicotine (GN) and exposed to nicotine and treated by L-arginine (GAN) may be explained by decreased proliferation of fibroblasts and macrophages induced by nicotine 2 .…”

Section: Dias Groupsmentioning

confidence: 99%

“…The smoking habit is given as a cause of healing changes secondary to the harmful effects of nicotine on the vasculature, especially in skin flaps. Alternatives to avoid these effects have been the subject of scientific research 2 . Wound healing is a dynamic process involving biochemical and physiological phenomena 3 .…”

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

“…The influence of nicotine on the impaired relaxation of endothelium in the pathogenesis of ischemic skin flaps and the potential use of nitric oxide precursor for the prevention or treatment of these ischemic processes have been described 7,8 . Thus, L-arginine stands out as a physiological precursor in nitric oxide synthesis 2,9 . Considering the antiangiogenic effect induced by smoking habit and the search for alternatives that can provide smokers with a better postoperative healing condition from the angiogenic standpoint, and also considering the effect of nitric oxide as an arginine catabolite to stimulate angiogenesis, this study aims to evaluate whether treatment with arginine in rats previously exposed to nicotine and making undergoing skin flaps, influences angiogenesis in the healing process of these flaps.…”

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

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Ação da l-arginina na evolução de retalhos cutâneos de ratos sob exposição à nicotina

Guimarães

Moreira

Rocha

et al. 2013

Rev. Col. Bras. Cir.

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OBJETIVO: Avaliar se o tratamento com L-arginina influencia a cicatrização de retalhos cutâneos em ratos expostos à nicotina. MÉTODOS: Foram utilizados 40 ratos Wistar pesando 142,4±10,1g separados em quatro grupos: GC- tratamento com solução tampão fosfatos pH 7,4, confecção de retalho cutâneo, observação por 10 dias; GN- exposição à nicotina por quatro semanas, confecção de retalho cutâneo, observação por dez dias; GA- tratamento com solução tampão fosfatos pH 7,4 por quatro semanas, confecção de retalho cutâneo, tratamento com arginina por dez dias; GAN- exposição à nicotina por quatro semanas, confecção de retalho cutâneo, tratamento com arginina por dez dias. Foram avaliadas as áreas de necrose, re-epitelização, reação inflamatória e formação de tecido de granulação, pela coloração HE, a área de deposição total e a diferenciação de colágenos I e III por histometria com a coloração de picrosirius, e, através da marcação imunoistoquímica com anticorpo monoclonal anti-CD34, a densidade vascular cicatricial. RESULTADOS: As porcentagens de áreas de necrose de GN e GNA foram maiores (p<0,001) do que GC e GA. Nos escores histológicos, a deposição de colágeno e a porcentagem de colágeno tipo I, no GC e GA foram similares (p>0,05) e maiores (p<0,001) do que em GA e em GNA e, nas densidades vasculares, GN e GAN foram menores (p<0,001) do que em GC e em GA. CONCLUSÃO: A exposição à nicotina inibiu os efeitos da arginina, e nos ratos não expostos, induziu melhora na angiogênese e na deposição de colágeno total nos retalhos cutâneos.

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“…[4][5][6][7][8] Smoking has also been shown to impair soft tissue wound healing in humans and in a number of animal models. [9][10][11][12][13][14][15] While no previous studies have examined the relationship between ligament healing and smoking, ligament healing represents a soft tissue wound repair response likely affected by exposure to cigarette smoke.…”

Section: Introductionmentioning

confidence: 99%

Effects of cigarette smoking on early medial collateral ligament healing in a mouse model

Gill¹,

Sandell²,

El-Zawawy³

et al. 2006

J. Orthop. Res.

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Cigarette smoking delays the healing process and increases morbidity associated with many common musculoskeletal disorders such as medial collateral ligament (MCL) injury. In the current study, a murine model of MCL healing was used to test the hypothesis that smoking impairs extracellular matrix synthesis after injury. Mice were divided into two groups, a nonsmoking control group and a group exposed to smoke for 2 months prior to surgical MCL injury. Mice were euthanized at 3 and 7 days after surgery. Subsequently, propidium iodine staining was used to quantify cellular density of injured and sham ligaments. Immunohistochemical staining and in situ hybridization to mRNA were used to detect proliferation, apoptosis, and type I collagen gene expression at the site of injury. Cell density increased significantly from baseline to 7 days after injury in control mice. In mice exposed to cigarette smoke, there was a significantly lower cellular density compared to controls at this time point ( p ¼ 0.01). There was no difference in proliferation between groups at the site of injury, and the low level of proliferation observed was not sufficient to account for the large increase in cell density by day 7. No evidence of apoptosis was observed in any of the groups at the site of injury. Type I collagen gene expression was higher in controls compared to smokers at day 7. Almost all of the cells in the substance of the injured MCL at day 7 were spindle-shaped and expressed type I collagen, suggesting that increased cell density from day 3 to day 7 represented an increase in ligament cells rather than an increased inflammatory response. We conclude that the decreased cellular density and type I collagen expression in the injured ligament of mice exposed to smoke begin to provide a cellular and molecular basis for delayed or deficient early healing in these animals. ß

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Nicotine and Its Effect on Wound Healing

Cited by 170 publications

References 0 publications

The effect of cigarette smoking on musculoskeletal‐related disability

The effect of cigarette smoking on musculoskeletal‐related disability

Ação da l-arginina na evolução de retalhos cutâneos de ratos sob exposição à nicotina

Effects of cigarette smoking on early medial collateral ligament healing in a mouse model

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