2009
DOI: 10.1124/pr.108.000562
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Nicotinic Acetylcholine Receptor Signalling: Roles in Alzheimer's Disease and Amyloid Neuroprotection

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Cited by 272 publications
(208 citation statements)
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References 245 publications
(271 reference statements)
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“…Conopeptides exhibit antinociceptive, antiepileptic, neuroprotective or cardioprotective activities and thus have pharmacological applications in cancer, neuromuscular and psychiatric disorders (Figure 2). Conotoxins can be potentially used for pain therapeutics as they target the neuronal nAChR and thus have relevance in therapeutics of neurological diseases like alzheimer's disease, multiple sclerosis, diabetic neuropathy, shingles, and others [52,53]. Numerous venombased antinociceptive agents are at various stages of development for therapeutic use.…”
Section: Conotoxin: Pharmacological Targets and Applicationsmentioning
confidence: 99%
“…Conopeptides exhibit antinociceptive, antiepileptic, neuroprotective or cardioprotective activities and thus have pharmacological applications in cancer, neuromuscular and psychiatric disorders (Figure 2). Conotoxins can be potentially used for pain therapeutics as they target the neuronal nAChR and thus have relevance in therapeutics of neurological diseases like alzheimer's disease, multiple sclerosis, diabetic neuropathy, shingles, and others [52,53]. Numerous venombased antinociceptive agents are at various stages of development for therapeutic use.…”
Section: Conotoxin: Pharmacological Targets and Applicationsmentioning
confidence: 99%
“…8 There is also a confirmed link between AD and cholinergic signaling of the brain in abundant available evidences. 9 Degeneration of nuclei in the basal forebrain results in a loss of excitatory cholinergic transmission to the cerebral cortex and this is thought to contribute significantly to the cognitive deficits present in Alzheimer's disease. 10 Depletion of the neurotransmitter acetylcholine in AD due to reduced number of acetylcholine receptor and increased activity of acetylcholine-esterase are considered as prominent features of AD.…”
Section: Introductionmentioning
confidence: 99%
“…This subtype of nAChR has major pre-synaptic roles in the brain [4], which include regulating the release of dopamine from nerve terminals in the dopaminergic reward pathway [5,6]. The activation of α7 nAChRs is neuroprotective against toxicity resulting from exposure to the neurotoxic β-amyloid peptide, Aβ1-42, important in Alzheimer's disease and other toxins [7]. The α7 nAChRs participate in auditory sensory gating, defects in which contribute to the attention and cognitive problems associated with schizophrenia [8,9].…”
Section: Introductionmentioning
confidence: 99%