Nigrostriatal dopamine transporter availability, and its metabolic and clinical correlates in Parkinson’s disease patients with impulse control disorders

Navalpotro‐Gómez, Irene; Dacosta-Aguayo, Rosalía; Molinet-Dronda, Francisco; Martín-Bastida, Antonio; Botas-Peñin, A; Jiménez-Urbieta, Haritz; Delgado-Alvarado, Manuel; Gago, Belén; Quiroga-Varela, Ana; Rodriguez-Oroz, María C.

doi:10.1007/s00259-019-04396-3

Cited by 12 publications

(4 citation statements)

References 57 publications

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“…The density of dopamine transporters (DAT), responsible for the reuptake of dopamine from the synaptic cleft, may also play a key role. Single photon emission computed tomography (Cilia et al, 2010;Voon et al, 2014;Navalpotro-Gomez et al, 2019) and PET (Lee et al, 2014) investigations have demonstrated reduced striatal DAT binding in PD + ICD compared to PD-ICD. Furthermore, two studies have shown that decreased DAT availability precedes ICD development following DRTs and that the severity of ICDs experienced is inversely correlated with DAT density (Vriend et al, 2014;Smith et al, 2016), highlighting the potential use of baseline DAT density as a marker of future ICD risk in PD patients.…”

Section: Mechanisms Underlying Pd + Icd: Human Studiesmentioning

confidence: 99%

Impulse Control Disorders in Parkinson’s Disease: From Bench to Bedside

2021

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Parkinson’s disease (PD) is a neurodegenerative disorder that is characterized by symptoms that impact both motor and non-motor domains. Outside of motor impairments, PD patients are at risk for impulse control disorders (ICDs), which include excessively disabling impulsive and compulsive behaviors. ICD symptoms in PD (PD + ICD) can be broadly conceptualized as a synergistic interaction between dopamine agonist therapy and the many molecular and circuit-level changes intrinsic to PD. Aside from discontinuing dopamine agonist treatment, there remains a lack of consensus on how to best address ICD symptoms in PD. In this review, we explore recent advances in the molecular and neuroanatomical mechanisms underlying ICD symptoms in PD by summarizing a rapidly accumulating body of clinical and preclinical studies, with a special focus on the utility of rodent models in gaining new insights into the neurochemical basis of PD + ICD. We also discuss the relevance of these findings to the broader problem of impulsive and compulsive behaviors that impact a range of neuropsychiatric syndromes.

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Section: Mechanisms Underlying Pd + Icd: Human Studiesmentioning

confidence: 99%

Impulse Control Disorders in Parkinson’s Disease: From Bench to Bedside

2021

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“…In the same line, a recent study suggests that brain metabolism is more preserved in PD-ICD patients than in patients without ICD, which could be related to ICD development (191). In contrast, a single study in PD-ICDs patients reported an association of lower DAT availability in the VS with lower FDG uptake in several cortical areas belonging to the limbic and associative circuits as well as in other regions involved in reward and inhibition processes (198). All these evidences can be matter of debate regarding metabolic studies in general population, which have largely demonstrated that, the hypometabolism of brain regions from "control networks" such as the PFC or the ACC could increase their vulnerability to relapse since it would interfere with cognitive inhibition.…”

Section: Glucose Metabolismmentioning

confidence: 98%

Imaging Cognitive Impairment and Impulse Control Disorders in Parkinson's Disease

et al. 2021

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Dementia and mild forms of cognitive impairment as well as neuropsychiatric symptoms (i. e., impulse control disorders) are frequent and disabling non-motor symptoms of Parkinson's disease (PD). The identification of changes in neuroimaging studies for the early diagnosis and monitoring of the cognitive and neuropsychiatric symptoms associated with Parkinson's disease, as well as their pathophysiological understanding, are critical for the development of an optimal therapeutic approach. In the current literature review, we present an update on the latest structural and functional neuroimaging findings, including high magnetic field resonance and radionuclide imaging, assessing cognitive dysfunction and impulse control disorders in PD.

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“…Commonly in PD, the accumbens is referred to the pathophysiology of ICD under dopamine replacement therapy. PET imaging of the dopaminergic system revealed that ICDs are associated with a reduction of D2/D3 receptor availability [ 237 , 238 ], dopamine synthesis capacity [ 146 ], and DAT density [ 239 ] in this region. These “hypodopaminergic” changes of the accumbens are critically involved in ICD and were previously embedded in a vulnerability-stress model for the development of ICD.…”

Section: Regions Of the Limbic Systemmentioning

confidence: 99%

Imaging the Limbic System in Parkinson’s Disease—A Review of Limbic Pathology and Clinical Symptoms

et al. 2022

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The limbic system describes a complex of brain structures central for memory, learning, as well as goal directed and emotional behavior. In addition to pathological studies, recent findings using in vivo structural and functional imaging of the brain pinpoint the vulnerability of limbic structures to neurodegeneration in Parkinson’s disease (PD) throughout the disease course. Accordingly, dysfunction of the limbic system is critically related to the symptom complex which characterizes PD, including neuropsychiatric, vegetative, and motor symptoms, and their heterogeneity in patients with PD. The aim of this systematic review was to put the spotlight on neuroimaging of the limbic system in PD and to give an overview of the most important structures affected by the disease, their function, disease related alterations, and corresponding clinical manifestations. PubMed was searched in order to identify the most recent studies that investigate the limbic system in PD with the help of neuroimaging methods. First, PD related neuropathological changes and corresponding clinical symptoms of each limbic system region are reviewed, and, finally, a network integration of the limbic system within the complex of PD pathology is discussed.

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Nigrostriatal dopamine transporter availability, and its metabolic and clinical correlates in Parkinson’s disease patients with impulse control disorders

Cited by 12 publications

References 57 publications

Impulse Control Disorders in Parkinson’s Disease: From Bench to Bedside

Impulse Control Disorders in Parkinson’s Disease: From Bench to Bedside

Imaging Cognitive Impairment and Impulse Control Disorders in Parkinson's Disease

Imaging the Limbic System in Parkinson’s Disease—A Review of Limbic Pathology and Clinical Symptoms

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