“…Next, the late trophozoites developed into blood-stage schizont and released from ruptured RBC together with metabolic waste and residual bodies (responsible for the characteristic symptoms of malaria). After an indeterminate number of asexual cycles, some of the merozoites will enter erythrocytes and become macro-and microgamonts to be ingested by the mosquito for sexual reproduction and the cycle is repeated (Figure 1) (Cowman et al, 2012;Abdel-Ghaffar et al, 2019).…”