Nimbolide attenuated the inflammation in the liver of autoimmune hepatitis's mice through regulation of HDAC3

Xia, Dingchao; Chen, Runsheng; Cai, Tingchen; Zhu, Lujian; Lin, Yanhan; Yu, Sijie; Zhu, Kailu; Wang, Xiaodong; Xu, Lei; Chen, Yongping

doi:10.1016/j.taap.2021.115795

Cited by 7 publications

(6 citation statements)

References 38 publications

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“…These data suggest that inflammation is a characteristic of AIH. Indeed, in another study, nimbolide, an inflammatory agent, is shown to reduce inflammation in the AIH model in mice 15 . Moreover, steroids are the treatment of choice in AIH, which modulates inflammation.…”

Section: Discussionmentioning

confidence: 94%

Could a reduced hemoglobin, albumin, lymphocyte, and platelet (HALP) score predict autoimmune hepatitis and degree of liver fibrosis?

Ustaoglu,

Aktas,

Kucukdemirci

et al. 2024

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: Autoimmune hepatitis is a rare inflammatory disease of the liver that is characterized by elevated liver enzymes. The hemoglobin, albumin, lymphocyte, and platelet score, which is derived from hemoglobin, serum albumin, circulating lymphocyte count, and platelet count, is also associated with inflammatory conditions. The aim was to examine the hemoglobin, albumin, lymphocyte, and platelet score of patients with autoimmune hepatitis and to compare it to that of healthy individuals in this retrospective analysis. METHODS: Subjects diagnosed with autoimmune hepatitis were enrolled in the study, and healthy individuals were enrolled as controls. Moreover, autoimmune hepatitis subjects were grouped into mild or moderate/advanced fibrosis. Furthermore, aspartate to platelet ratio index, Fibrosis-4, and hemoglobin, albumin, lymphocyte, and platelet scores of the autoimmune hepatitis patients and controls were compared. In addition, the hemoglobin, albumin, lymphocyte, and platelet score of the autoimmune hepatitis patients with mild fibrosis is compared to that of those with moderate/advanced fibrosis. RESULTS: The mean hemoglobin, albumin, lymphocyte, and platelet score of the autoimmune hepatitis patients was 44.2±14.5 while this value was 76.8±15.5 in control subjects. The hemoglobin, albumin, lymphocyte, and platelet score was significantly reduced in autoimmune hepatitis patients than healthy controls (p<0.001). The hemoglobin, albumin, lymphocyte, and platelet score was significantly and negatively correlated with C-reactive protein, aspartate, alanine transaminase, gamma glutamyl transferase, aspartate to platelet ratio index, and Fibrosis-4 values. A hemoglobin, albumin, lymphocyte, and platelet score that was lower than 52.3 had 83% sensitivity and 73% specificity in predicting autoimmune hepatitis. The sensitivity and specificity of the hemoglobin, albumin, lymphocyte, and platelet score were higher than the Fibrosis-4 score in predicting moderate/advanced fibrosis in autoimmune hepatitis. CONCLUSION: We suggest that the hemoglobin, albumin, lymphocyte, and platelet score be used as an additional noninvasive diagnostic tool for autoimmune hepatitis and to predict moderate/advanced liver fibrosis in patients with autoimmune hepatitis.

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Section: Discussionmentioning

confidence: 94%

Could a reduced hemoglobin, albumin, lymphocyte, and platelet (HALP) score predict autoimmune hepatitis and degree of liver fibrosis?

Ustaoglu,

Aktas,

Kucukdemirci

et al. 2024

Rev. Assoc. Med. Bras.

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“…Nimbolide showed immense antioxidant properties. Nimbolide prevented ccl4-induced lipid peroxidation ( 33 ), and protected AML12 cells from LPS-induced damage ( 42 ). Shu and co-workers demonstrated the potential of nimbolide to reduce food intake and blood glucose, and body weight in STZ-provoked animals.…”

Section: Nimbolide Molecular Targetsmentioning

confidence: 99%

“…Nimbolide protects the hepatocellular membrane from damage caused by CCl4 ( 71 ). Nimbolide inhibits HDAC3 expression in autoimmune hepatitis (AIH) mice’s liver and AML12 cells to inhibit inflammation ( 42 ). Furthermore, long-term administration demonstrated significant histopathological protection of both liver and kidney without causing any adverse effects on liver and kidney ( 72 ).…”

Section: Protective Effects Of Nimbolide With Different Mechanisms In...mentioning

confidence: 99%

“…Nimbolide treatment resulted in a reduction of the inflammatory cytokines IL-6, IL-1β, and TNF-α, as well as inflammatory cellular signaling molecules IkB-α, STAT3, and NF-kB. Nimbolide blocks HDAC3 expression, reducing inflammation in the liver of AIH mice and in AML12 cells ( 42 ). Glutathione peroxidase, catalase (CAT), concentration were all found to be up, while malondialdehyde and nitric oxide levels were shown to be significantly reduced by nimbolide.…”

Section: Protective Effects Of Nimbolide With Different Mechanisms In...mentioning

confidence: 99%

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Nimbolide: promising agent for prevention and treatment of chronic diseases (recent update)

Rajendran,

Renu,

Abdallah

et al. 2024

Food & Nutrition Research

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Background: Nimbolide, a bioactive compound derived from the neem tree, has garnered attention as a potential breakthrough in the prevention and treatment of chronic diseases. Recent updates in research highlight its multifaceted pharmacological properties, demonstrating anti-inflammatory, antioxidant, and anticancer effects. With a rich history in traditional medicine, nimbolide efficacy in addressing the molecular complexities of conditions such as cardiovascular diseases, diabetes, and cancer positions it as a promising candidate for further exploration. As studies progress, the recent update underscores the growing optimism surrounding nimbolide as a valuable tool in the ongoing pursuit of innovative therapeutic strategies for chronic diseases. Methods: The comprehensive search of the literature was done until September 2020 on the MEDLINE, Embase, Scopus and Web of Knowledge databases. Results: Most studies have shown the Nimbolide is one of the most potent limonoids derived from the flowers and leaves of neem (Azadirachta indica), which is widely used to treat a variety of human diseases. In chronic diseases, nimbolide reported to modulate the key signaling pathways, such as Mitogen-activated protein kinases (MAPKs), Wingless-related integration site-β (Wnt-β)/catenin, NF-κB, PI3K/AKT, and signaling molecules, such as transforming growth factor (TGF-β), Matrix metalloproteinases (MMPs), Vascular Endothelial Growth Factor (VEGF), inflammatory cytokines, and epithelial-mesenchymal transition (EMT) proteins. Nimbolide has anti-inflammatory, anti-microbial, and anti-cancer properties, which make it an intriguing compound for research. Nimbolide demonstrated therapeutic potential for osteoarthritis, rheumatoid arthritis, cardiovascular, inflammation and cancer. Conclusion: The current review mainly focused on understanding the molecular mechanisms underlying the therapecutic effects of nimbolide in chronic diseases.

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“…[15,16] Nimbolide a potent phyto-constituent isolated from the flower and leaves of the Azadirachta India (a very popular herbs in China). [17,18] Traditionally, the different part of the plant used in the treatment of tooth disease, diabetes treatment, eczema, and fever. [17,[19][20][21] Nimbolide exhibited numerous pharmacological effects such as antibacterial, antimalarial, anti-inflammatory, antidiabetic, and anticancer effects.…”

Section: Introductionmentioning

confidence: 99%

Antiosteoporosis and bone protective effect of nimbolide in steroid‐induced osteoporosis rats

Huo

Ding

Wei

et al. 2022

J Biochem & Molecular Tox

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Background Osteoporosis is a metabolic, hereditary, progressive disease characterized by unusual bone production across the skeleton and a loss the bone tissue microstructure and mass. In this experimental study, we scrutinized the antiosteoporosis effect of nimbolide against glucocorticoid (GCs) induced osteoporosis in rats. Methods Swiss albino female rats were employed for the current experiment study and the rats were divided into different groups. Dexamethasone (0.1 mg/kg/day) was used for induction the osteoporosis and the rats were received the different doses of nimbolide (2.5, 5, and 7.5 mg/kg) for the estimation of bone protective effects. The body weight was estimated (initially and finally). Hormones, bone metabolic markers, bone turnover markers, bone structure, biomechanical, histomorphometric dynamic, biochemical markers, and histomorphometric static parameters were analyzed. Results The body weight of GCs group rats considerably suppressed and nimbolide treatment remarkably improved the body weight. Nimbolide treated group exhibited the enhancement of bone metabolic, bone structure markers, and histomophometric dynamic markers, which was suppressed during the GCs‐induced osteoporosis. GCs‐induced osteoporosis rats exhibited the enhancement of procollagen type 1 C‐terminal propeptide (P1CP), carboxy‐terminal crosslinked telopeptide of type 1 collagen (CTX‐1), Dickkopf‐1 (DKK1), tartrate‐resistant acid phosphatase 5b (TRACP 5b), and suppressed the level of bone alkaline phosphatase (BAP), which was reversed by the nimbolide treatment. Nimbolide treatment remarkably improved the level of estradiol and suppressed the level of parathyroid hormone (PTH), which was altered during the osteoporosis. Nimbolide treatment significantly (p < 0.001) improved the level of calcium, magnesium, and phosphorus in the serum and bone tissue. Nimbolide treatment also altered the level of bone metabolic markers and suppressed the level of inflammatory cytokines. Conclusion Based on the findings, we may conclude that nimbolide has antiosteoporosis properties via balancing the bone mass and improving vitamin and hormone levels.

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Nimbolide attenuated the inflammation in the liver of autoimmune hepatitis's mice through regulation of HDAC3

Cited by 7 publications

References 38 publications

Could a reduced hemoglobin, albumin, lymphocyte, and platelet (HALP) score predict autoimmune hepatitis and degree of liver fibrosis?

Could a reduced hemoglobin, albumin, lymphocyte, and platelet (HALP) score predict autoimmune hepatitis and degree of liver fibrosis?

Nimbolide: promising agent for prevention and treatment of chronic diseases (recent update)

Antiosteoporosis and bone protective effect of nimbolide in steroid‐induced osteoporosis rats

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