Niosomes: A Novel Trend in Drug Delivery

Mohanty, Dibyalochan; Jhansi, M.; Bakshi, Vasudha; Haque, M. Akiful; Swapna, S; Sahoo, Chinmaya Keshari; Upadhyay, Atul Kumar

doi:10.5958/0974-360x.2018.00950.2

Cited by 16 publications

(9 citation statements)

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“…Texture analysis: A texture analyzer can be used to determine the firmness, homogeneity, and cohesiveness of the formulation for primary indicators of the syringe capacity of sol so that the preparations are simple to deliver in vivo. [ 67 ]…”

Section: Evaluation Of In Situ Gelsmentioning

confidence: 99%

“…[ 59 ] Texture analysis: A texture analyzer can be used to determine the firmness, homogeneity, and cohesiveness of the formulation for primary indicators of the syringe capacity of sol so that the preparations are simple to deliver in vivo. [ 67 ] Sterility testing: According to IP 1996, sterility testing is done. In this test, the formulation is incubated for 14 days at 30–35 °C in a fluid thioglycollate medium to look for bacterial growth and at 200–25 °C in a soybean casein digest medium to look for fungal growth.…”

Section: Evaluation Of In Situ Gelsmentioning

confidence: 99%

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Exploring the Transformative Potential of In Situ Gels: An Overview of Thermosensitive and pH‐Sensitive Gel Systems for Biomedical Applications

Patil,

Chougule

et al. 2024

Macromolecular Symposia

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In situ gel systems have emerged as promising drug delivery platforms due to their numerous benefits, including increased patient compliance and decreased administration frequency. The potential of in situ gel extends beyond its formulation benefits, with the ability to transform medical treatment by enhancing drug delivery, offering personalized therapies, and introducing innovative approaches. Ongoing research and the efforts of pharmaceutical companies are dedicated to exploring the vast opportunities presented by in situ gel, pushing the limits of innovation in the field of drug delivery. The selection of suitable polymers is critical for the development of in situ gel formulations. Additionally, consideration of drug‐polymer compatibility ensures the stability and efficacy of the drug within the gel matrix. Formulation considerations play a pivotal role in the development of effective in situ gel systems. They have shown great potential in drug delivery systems, tissue engineering, and regenerative medicine. The ability to prolong gastric retention time, targeted delivery, and localized drug release are among the advantages offered by in situ gels. Although in situ gel technology has shown significant advancements, challenges remain, including stability and shelf‐life issues, biocompatibility and safety concerns, and the need for further research and development. Future directions focus on overcoming these challenges and exploring new applications and advancements in the field. In conclusion, in situ gel systems provide a versatile and promising drug delivery and tissue engineering platform. However, further research and development are essential to address the challenges and fully harness the potential of this innovative technology.

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Section: Evaluation Of In Situ Gelsmentioning

confidence: 99%

Section: Evaluation Of In Situ Gelsmentioning

confidence: 99%

Exploring the Transformative Potential of In Situ Gels: An Overview of Thermosensitive and pH‐Sensitive Gel Systems for Biomedical Applications

Patil,

Chougule

et al. 2024

Macromolecular Symposia

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“…Improves the average overall efficiency of drug molecule recovery by using delayed clearance from the bloodstream, protecting the drug from its natural environment, and limiting its effect on target cells [24]. DISADVANTAGE OF NIOSOMES: IJBPAS, January, 2023, 12(1) The product's availability on a particular web page is better than just protecting the product in its natural environment.…”

Section: Surfactantsmentioning

confidence: 99%

A Detailed Review on Niosomes; Recent Advancements in Formulations, Characterization and Its Applications

2023

IJBPAS

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A Niosomes is a non-ionic surfactant based liposomes, found to be mixture of cholesterol and non-ionic surfactants and are proved to be a promising drug carrier and has potential to reduce the side effects of drugs and increased therapeutic effectiveness in various diseases. Niosomes are multilamellar or unilamellar vesicles in which an aqueous solute solution is completely encapsulated by a membrane formed by surfactant macromolecules organised as a bilayer. Their structure is identical to that of a liposome, hence they can be used to represent alternate vesicular systems to liposomes. Niosomes addressed the issues related to drug insolubility, instability, low bioavailability, and rapid deterioration. This overview article represents the structure of niosomes, advantages, disadvantages, methods for niosomes preparations, characterization, and its application of the vesicular system.

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“…On the other hand, bioadhesiveness accompanied with in situ gelling propertis fascilitated drug targeting through mucus membranes. 145 Synthesis was triggered without any need of toxic chemical cross-linker, physico- functionalized with cholesterol and aldehyde group to utilize as a potential platform for doxorubicin release. 146 Again, simple blending of arboxymethyl hexanoyl chitosan/HA produced in situ gel with injectable property.…”

Section: In Situ Gellingmentioning

confidence: 99%

Recent Development of Polysaccharide-Derived Hydrogel: Properties, Stimuli-Responsiveness and Bioapplications

Mukherjee

2022

Preprint

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Hydrogels are three-dimensional, hydrophilic, polymeric frameworks, constructed through diverse physical or chemical crosslinks. Recent research focuses on their physiological stimuli sensitivity enhancing bioapplications. Biopolymers with responsiveness to local environment like temperature, pH etc. form the foundation in this regard, around which all major natural processes are circulated. Polysaccharides, being most the abundant biopolymers and essential constituent of our daily food like cereals and fruits, are readily available in nature. Hence, among numerous biomacromolecules, polysaccharides are extensively used to prepare hydrogel recently. However, incorporation of certain properties to these gels through derivatization can trigger stimuli responsiveness suitable for various applications especially in biomedical field inspired from the mother nature. For example, in situ cross-linking ability may deliver an intermediate platform between solid scaffolds and saline injections through reversible or irreversible sol-gel transition. Easy injectability provides patient’s relief through reducing recovery time and inflectional hazards. Self recovery of gel within body results automatic inflammation and damage recovery of tissues. This review provides a detail impression on the synthesis of natural polysaccharide derived hydrogel network with structural classification to bulk, supramolecular, micro and nano gel. Several properties important from biomedical point such as in situ, injectable, self healing nature of these hydrogels and various physical, chemical, or biochemical stimuli-responsive characteristics are discussed further. Lastly, their major bioapplications are highlighted.

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Niosomes: A Novel Trend in Drug Delivery

Cited by 16 publications

References 0 publications

Exploring the Transformative Potential of In Situ Gels: An Overview of Thermosensitive and pH‐Sensitive Gel Systems for Biomedical Applications

Exploring the Transformative Potential of In Situ Gels: An Overview of Thermosensitive and pH‐Sensitive Gel Systems for Biomedical Applications

A Detailed Review on Niosomes; Recent Advancements in Formulations, Characterization and Its Applications

Recent Development of Polysaccharide-Derived Hydrogel: Properties, Stimuli-Responsiveness and Bioapplications

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