Niosomes in Malaria

Patel, Geeta K.; Prajapati, Bhupendra G.; Pathak, Yashawant

doi:10.1007/978-3-031-15848-3_12

Cited by 3 publications

(1 citation statement)

References 96 publications

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“…Traditional techniques utilized in the synthesis of gold nanoparticles (AuNPs) frequently entail the utilization of hazardous substances and costly methodologies, thereby accentuating environmental hazards and impending its clinical application despite its captivating attributes [14]. Hence, the exploration of a straightforward, environmentally friendly and economically viable approach becomes a signi cant imperative.…”

Section: Introductionmentioning

confidence: 99%

Bio-synthesis of gold nanoparticles from Codariocalyx motorius leaf extract: Physiochemical evaluation, antimicrobial, antioxidant and anticancer activity against Hep G2 cell lines

Deivanathan,

Dayana,

Prakash

2023

Preprint

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This research delved into the synthesis of gold nanoparticles (AuNPs) utilizing leaf extract derived from Codariocalyx motorius (C.motorius). The confirmation of C.motorius gold nanoparticles (CM-AuNPs) formation was established through the visual observation of color changes in the colloidal solution. A comprehensive characterization of CM-AuNPs employed UV-vis spectroscopy, FT-IR, FE-SEM, EDAX, XRD, HR-TEM, DLZ and Zeta potential. The UV- vis spectrum exhibited a distinctive peak at 534 nm, indicative of CM-AuNPs. The FT-IR spectrum identified the presence of -OH and -NH functional groups intricately associated with the AuNPs. HR-SEM analysis revealed average size of approximately 44 nm for the CM-AuNPs. XRD confirmed the face-centered cubic crystallinity of CM-AuNPs. In the DPPH assay, the bio-synthesized CM-AuNPs demonstrated robust antioxidant activity, displaying an IC50 of 61.27%. Moreover, the bio-synthesized CM-AuNPs exhibited significant antibacterial efficacy against both gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria. Inhibition values for these bacteria were recorded at 6 ± 2.94392 mm and 5 ± 2.58199 mm respectively. Further, the bio-synthesized AuNPs showcased antiproliferative activity against Hep G2 cells, with an IC50 value 6.89 µg/mL. These compelling findings underscore the potential applications of CM-AuNPs, synthesized from C.motorius leaf extract in the realm of medication delivery.

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Section: Introductionmentioning

confidence: 99%

Bio-synthesis of gold nanoparticles from Codariocalyx motorius leaf extract: Physiochemical evaluation, antimicrobial, antioxidant and anticancer activity against Hep G2 cell lines

Deivanathan,

Dayana,

Prakash

2023

Preprint

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Nanotechnology based drug delivery systems for malaria

Keleş,

Alakbarli,

Akgül

et al. 2024

International Journal of Pharmaceutics

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Cardioprotective Potential of Moringa Oleifera Leaf Extract Loaded Niosomes Nanoparticles - Against Doxorubicin Toxicity In Rats

Mohamad,

Ahmed,

Masoud

et al. 2025

CPB

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Introduction: Doxorubicin (DOX) is one of the most potent anticancer drugs that has ubiquitous usage in oncology; however, its marked adverse effects, such as cardiotoxicity, are still a major clinical issue. Plant extracts have shown cardioprotective effects and reduced the risk of cardiovascular diseases. Method: The current study is intended to explore the cardioprotective effect of ethanolic Moringa oleifera extracts (MOE) leaves loaded into niosomes (MOE-NIO) against DOXinduced cardiotoxicity in rats. MOE niosomes nanoparticles (NIO-NPs) were prepared and characterized by TEM. Seventy male Wistar rats were randomly divided into seven groups: control, NIO, DOX, DOX+MOE, DOX+MOE-NIO, MOE+DOX, and MOE-NIO+DOX. DOX (4 mg/kg, IP) was injected once per week for 4 weeks with daily administration of MOE or MOENIO (250 mg/kg, PO) for 4 weeks; in the sixth and seventh groups, MOE or MOE-NIO (250 mg/kg, PO) was administered one week before DOX injection. Various parameters were assessed in serum and cardiac tissue. Pre and co-treatment with MOE-NIO have mitigated the cardiotoxicity induced by DOX as indicated by serum aspartate aminotransferase (AST), creatine kinase - MB(CK-MB) and lactate dehydrogenase (LDH), cardiac Troponin 1(cTn1) and lipid profile. MOE-NIO also alleviated lipid peroxidation (MDA), nitrosative status (NO), and inflammatory markers levels; myeloperoxidase (MPO) and tumor necrosis factor-alpha (TNF-α) obtained in DOX-treated animals. Additionally, ameliorated effects have been recorded in glutathione content and superoxide dismutase activity. MOE-NIO effectively neutralized the DOXupregulated nuclear factor kappa B (NF-kB) and p38 mitogen-activated protein kinases (p38 MAPK), and DOX-downregulated nuclear factor-erythroid 2-related factor 2 (Nrf2) expressions in the heart. Results: It is concluded that pre and co-treatment with MOE-NIO could protect the heart against DOX-induced cardiotoxicity by suppressing numerous pathways including oxidative stress, inflammation, and apoptosis and by the elevation of tissue antioxidant status. Conclusion: Thus, it may be reasonable to suggest that pre and co-treatment with MOE-NIO can provide a potential cardioprotective effect when doxorubicin is used in the management of carcinoma.

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Niosomes in Malaria

Cited by 3 publications

References 96 publications

Bio-synthesis of gold nanoparticles from Codariocalyx motorius leaf extract: Physiochemical evaluation, antimicrobial, antioxidant and anticancer activity against Hep G2 cell lines

Bio-synthesis of gold nanoparticles from Codariocalyx motorius leaf extract: Physiochemical evaluation, antimicrobial, antioxidant and anticancer activity against Hep G2 cell lines

Nanotechnology based drug delivery systems for malaria

Cardioprotective Potential of Moringa Oleifera Leaf Extract Loaded Niosomes Nanoparticles - Against Doxorubicin Toxicity In Rats

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