2023
DOI: 10.1097/pas.0000000000002063
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Nipple Adenoma

Abstract: Nipple adenoma (NA) is a rare, benign proliferation of the nipple ducts. It may be clinically mistaken for Paget disease or squamous cell carcinoma; thus, microscopic evaluation is paramount. A large case series of NA has not been undertaken since the 1980s. Therefore, we undertook this study to evaluate the clinicopathologic characteristics of NA, emphasizing differential diagnoses and follow-up data. We retrieved 50 cases from our in-house archives or consultation files between 2003 and 2022. Available slide… Show more

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Cited by 4 publications
(13 citation statements)
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“…We did not observe a preference in laterality between right and left nipples, contrary to some previous works. 2 NA and breast carcinoma, when concurrently observed, usually appear as independent lesions in distinct locations. Although a recognized association exists, the definitive link between NA and subsequent breast cancer development or a direct causal relationship for NA transforming into breast cancer has not been established but cannot be ruled out.…”
Section: Discussionmentioning
confidence: 99%
“…We did not observe a preference in laterality between right and left nipples, contrary to some previous works. 2 NA and breast carcinoma, when concurrently observed, usually appear as independent lesions in distinct locations. Although a recognized association exists, the definitive link between NA and subsequent breast cancer development or a direct causal relationship for NA transforming into breast cancer has not been established but cannot be ruled out.…”
Section: Discussionmentioning
confidence: 99%
“…The exudate is often described as "nipple discharge," raising the differential diagnosis of an underlying intraductal papilloma or carcinoma. In a contemporary series 40 69% of patients with clinical information were symptomatic, and the most common symptom was bloody nipple discharge (24% of patients). In another series, 83% of patients 39 had nipple erosion and discharge.…”
Section: Clinical Featuresmentioning
confidence: 99%
“…Fewer than 10% of patients reported nipple pain or itching. 39,40 Thickening of the epidermis, erythema, and ulceration associated with a nipple adenoma may also suggest a benign cutaneous lesion such as eczema or psoriasis, or an infectious process, 41 prompting initial treatment with topical antibiotics and/or steroids without resolution of the lesion. Given these presenting symptoms, most nipple adenomas are detected when the tumor has a relatively small size and consists of a superficial palpable nodule.…”
Section: Clinical Featuresmentioning
confidence: 99%
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