NIR- and thermo-responsive semi-interpenetrated polypyrrole nanogels for imaging guided combinational photothermal and chemotherapy

Electromagnetic radiation driving of volume changes in nanocomposites made of a thermosensitive hydrogel polymerized around conducting polymer nanoparticles

“…The nanocomposites synthesized and characterized in this work are good candidates for drug delivery systems driven remotely using radiofrequency or microwaves, as it has been shown with similar nanocomposites using NIR light. 70 This method of preparation, to the best of our knowledge, has not been used before to produce nanocomposites made of conducting polymer nanoparticles and hydrogel matrices. A comparison with other methods to produce the materials seems relevant and have been performed elsewhere.…”

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

“…Polypyrrole (PPY) with photothermal convention, which could be used for photoacoustic (PA) imaging, was introduced into dendritic polyglycerol (dPG) cross-linked poly(N-isopropylacrylamide-co-N-isopropylmethacrylamide) nanogels (p(NIPAm-co-NIPMAm)) by semi-interpenetration to form the PPY/Co-dPG nanogels. PPY/Co-dPG nanogels with near infrared (NIR)-responsive and hermoresponsive properties could be used for PA imaging-guided photo thermotherapy with NIR irradiation (Figure 1) [12].…”

“…Polypyrrole (PPY) with photothermal convention, which could be used for photoacoustic (PA) imaging, was introduced into dendritic polyglycerol (dPG) cross-linked poly(N-isopropylacrylamide-co-N-isopropylmethacrylamide) nanogels (p(NIPAm-co-NIPMAm)) by semi-interpenetration to form the PPY/Co-dPG nanogels. PPY/Co-dPG nanogels with near infrared (NIR)-responsive and hermoresponsive properties could be used for PA imagingguided photo thermotherapy with NIR irradiation (Figure 1) [12]. The N-isopropylacrylamide (NIPAm)-based polymer network and interpenetrated polypyrrole (PPY) enabled the nanogels with thermoresponsive property and near-infrared (NIR)-induced photothermal convention, respectively; (Pyrrole•HCl (Py•HCI) as the base and ammonium persulfate (APS) as an initiator were introduced for polymerization); the TEM images (B) and hydrodynamic size distribution (C) of PPY/Co-dPG nanogels.…”

Near-Infrared Light-Triggered Thermo-responsive Poly(N-Isopropylacrylamide)-Pyrrole Nanocomposites for Chemo-photothermal Cancer Therapy

“…1.13 g of NIPAM monomer, 0.077 g of MBA and 0.136 g of AAc were dissolved in 100 mL deionized water and added in a 250-mL three-neck roundbottom flask. After 30 min, the reaction temperature was increased to 80 °C and vigorous stirring for 1 h. To induce polymerization, KPS (1.5 mg) was added to the mixture, followed by stirring for 4 h. The mixture was dialyzed against a molecular weight cut off (MWCO) 12-14 kDa dialysis membrane in deionized water for 7 days to remove unreacted monomer, initiator, dispensable ions and PNIPAM-AAc nanoparticle was obtained by freeze-drying for 48 h. To functionalize the photothermal effect, ppy was decorated into PNIPAM-AAc nanoparticles [25]. PVP (50 and 100 mg) and pyrrole monomer (50 and 100 μL) were rapidly added in 10 mg/mL of PNI-PAM-AAc solution and were stirred for 12 h at room temperature.…”