NIR-controlled morphology transformation and pulsatile drug delivery based on multifunctional phototheranostic nanoparticles for photoacoustic imaging-guided photothermal-chemotherapy

Yang, Jun; Zhai, Shaodong; Qin, Huan; Yan, He; Xing, Da

doi:10.1016/j.biomaterials.2018.05.033

Cited by 113 publications

(70 citation statements)

References 80 publications

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“…In addition, Chen and co‐workers recently reported another PDI‐based contrast agent that can detect the ROS level in the tumor by PA imaging . In addition, chlorin dimers, polypyrrole, polylysine, smart organic NPs, natural humic‐acid‐based nanoagents, and tannic‐acid‐based assemblies have also been explored as contrast agents for PA imaging.…”

Section: Organic Contrast Agentsmentioning

confidence: 99%

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

et al. 2018

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Photoacoustic (PA) imaging as a fast‐developing imaging technique has great potential in biomedical and clinical applications. It is a noninvasive imaging modality that depends on the light‐absorption coefficient of the imaged tissue and the injected PA‐imaging contrast agents. Furthermore, PA imaging provides superb contrast, super spatial resolution, and high penetrability and sensitivity to tissue functional characteristics by detecting the acoustic wave to construct PA images. In recent years, a series of PA‐imaging contrast agents are developed to improve the PA‐imaging performance in biomedical applications. Here, recent progress of PA contrast agents and their biomedical applications are outlined. PA contrast agents are classified according to their components and function, and gold nanocrystals, gold‐nanocrystal assembly, transition‐metal chalcogenides/MXene‐based nanomaterials, carbon‐based nanomaterials, other inorganic imaging agents, small organic molecules, semiconducting polymer nanoparticles, and nonlinear PA‐imaging contrast agents are discussed. The applications of PA contrast agents as biosensors (in the sensing of metal ions, pH, enzymes, temperature, hypoxia, reactive oxygen species, and reactive nitrogen species) and in bioimaging (lymph nodes, vasculature, tumors, and brain tissue) are discussed in detail. Finally, an outlook on the future research and investigation of PA‐imaging contrast agents and their significance in biomedical research is presented.

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Section: Organic Contrast Agentsmentioning

confidence: 99%

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

et al. 2018

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“…2 Examples of inorganic nanomaterials include AuNPs, 27 black phosphorus, 25 carbon nanomaterials and UCNPs. 29 Various organic nanomaterials also have excellent properties for PTT (such as polymeric materials including polypyrrole (PPy) 32 and photothermal dyes including perylenediimide, 33 indocyanine green (ICG), 34 IR780 35 and IR825). 36 For organic nanomaterials, Yang et al fabricated NIRcontrolled drug-loaded nanoparticles for PTT-CHT.…”

Section: Photothermal Therapy In Cancer Treatmentmentioning

confidence: 99%

<p>Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment</p>

Wang¹,

Wu²,

Shen³

et al. 2020

IJN

163

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Background: Cancer is one of the major causes of death and is difficult to cure using existing clinical therapies. Clinical cancer treatments [such as surgery, chemotherapy (CHT), radiotherapy (RT) and immunotherapy (IT)] are widely used but they have limited therapeutic effects and unavoidable side effects. Recently, the development of novel nanomaterials offers a platform for combinational therapy (meaning a combination of two or more therapeutic agents) which is a promising approach for cancer therapy. Recent studies have demonstrated several types of nanomaterials suitable for photothermal therapy (PTT) based on a near-infrared (NIR) light-responsive system. PTT possesses favorable properties such as being low in cost, and having high temporospatial control with minimal invasiveness. However, short NIR light penetration depth limits its functions. Methods: In this review, due to their promise, we focus on inorganic nanomaterials [such as hollow mesoporous silica nanoparticles (HMSNs), tungsten sulfide quantum dots (WS 2 QDs), and gold nanorods (AuNRs)] combining PTT with CHT, RT or IT in one treatment, aiming to provide a comprehensive understanding of PTT-based combinational cancer therapy. Results: This review found much evidence for the use of inorganic nanoparticles for PTTbased combinational cancer therapy. Conclusion: Under synergistic effects, inorganic nanomaterial-based combinational treatments exhibit enhanced therapeutic effects compared to PTT, CHT, RT, IT or PDT alone and should be further investigated in the cancer field.

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“…Another study based on polypyrrole nanoparticles illustrated multifunctional roles in morphology transformation and controlled drug release. Upper critical solution temperature polymers were used to help achieve NIR laser‐controlled morphology changes for photothermal and chemotherapy (J. Yang et al, ). Under laser irradiation, the nanoparticles swelled from ~40 to ~200 nm.…”

Section: Physical‐responsive Nanomedicinementioning

confidence: 99%

Physical‐, chemical‐, and biological‐responsive nanomedicine for cancer therapy

Liao

Jia

et al. 2019

WIREs Nanomed Nanobiotechnol

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Cancer therapy is unsatisfactory as it typically has serious side effects, because normal cells in healthy organs are destroyed along with the tumor. Thus, researchers have tried to develop effective therapies with minimal side effects. One such method is to use nanotechnology to carry the drugs or therapeutic agents to the tumor region by secure encapsulation without leakage. Once the nanomedicine enters the target tumor site, it can release therapeutic agents in an effective manner. Accordingly, various nanomedicines have been developed to enhance the efficiency of cancer therapy and minimize the systematic toxicity. Here, we provide an overview and discuss the different types of responsive nanomedicines including physically, chemically, biologically, dual, and multi‐responsive nanomedicines, for the in situ release of cargos in recent years. We propose critical considerations that must be considered for the design of excellent stimuli‐nanomedicine. Furthermore, the possible directions for the development of successful stimuli‐responsive (smart) nanomedicine are highlighted. With the development of responsive nanomedicines, precise and personalized nanomedicine will be realized with great promise in the future. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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NIR-controlled morphology transformation and pulsatile drug delivery based on multifunctional phototheranostic nanoparticles for photoacoustic imaging-guided photothermal-chemotherapy

Cited by 113 publications

References 80 publications

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

<p>Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment</p>

Physical‐, chemical‐, and biological‐responsive nanomedicine for cancer therapy

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