NIR Laser‐Triggered Microneedle‐Based Liquid Band‐Aid for Wound Care

Abstract

Microneedles (MNs) have attracted widespread scientific and industrial interest in the past decade as an efficient, painless, low-cost, and relatively safe transdermal drug delivery device. However, their drawbacks such as insufficient dose accuracy and limited penetration depth may limit the clinical applications. Here, a light-controlled liquid band-aid based on MNs is developed for antibacterial applications. Metal-organic framework-derived peroxidase-like nanozyme loaded in MNs can not only convert light energy into heat to enhance drug permeation but also decompose hydrogen peroxide into hydroxyl radicals for antibacteria. The heat generated by the nanozyme can facilitate MNs to melt and form a liquid band-aid, which is beneficial to insulate the wound from the surrounding bacterial environment. These studies in a Staphylococcus aureus-infected mice model also prove that this laser-triggered liquid band-aid can efficiently reduce skin inflammation and promote wound healing. Together, these results demonstrate that the rational design of MNs can enhance antibacterial and wound healing efficiency.

Living symbiotic bacteria-involved skin dressing to combat indigenous pathogens for microbiome-based biotherapy toward atopic dermatitis

“…mucosa , PVP, PVA and SA. PVP and PVA have been widely used as restorative materials because they offer a physiologically benign environment for cell proliferation and migration [ [37] , [38] , [39] , [40] ]. In addition, PVA is up to date the only one among vinyl polymers suited as a carbon and energy source for bacteria [ [41] , [42] , [43] ].…”

Responsive hydrogel-based microneedle dressing for diabetic wound healing

“…Due to the specific microstructures, microneedle dressings possessed a fixation part which enhanced skin adhesion, played an essential role in transdermal drug delivery and promoted the process of wound healing. [24][25][26][27][28][29][30] Indeed, the resultant microneedle dressing exhibited adequate mechanical properties, and potent adhesion to the skin compared to hydrogels without microstructures (Fig. 4).…”

“…19 For example, bioinspired nanoarrays on silicone exhibited great adhesion to heart tissue; 20 moreover, bioinspired microneedle arrays provided mechanical interlocking and enhanced tissue adhesion, 21–23 therefore enhancing surgical closure and wound healing. 24–30…”

“…19 For example, bioinspired nanoarrays on silicone exhibited great adhesion to heart tissue; 20 moreover, bioinspired microneedle arrays provided mechanical interlocking and enhanced tissue adhesion, [21][22][23] therefore enhancing surgical closure and wound healing. [24][25][26][27][28][29][30] Based on the above considerations, in this work, we aim to develop a glucose-responsive insulin-releasing hydrogel microneedle dressing for diabetic wound repair (Scheme 1A). The hydrogel was prepared through in situ copolymerization of biocompatible gelatin methacrylate (GelMa), glucose-responsive monomer 4-(2-acrylamidoethylcarbamoyl)-3-fluorophenylboronic acid (AFPBA) and gluconic insulin (G-insulin).…”

NIR-responsive MoS2–Cu2WS4 nanosheets for catalytic/photothermal therapy of methicillin-resistant Staphylococcus aureus infections

“…Thus, it is promising to develop antibacterial agents by integrating the photothermal nanoagents with nanozymes, which may simultaneously improve the antibacterial efficiency of the catalytic therapy and reduce the potential side-effects of PTT. 32–34…”