Nitric Oxide Accelerates the Recovery from Burn Wounds

Zhu, Haifeng; Bian, Ka; Murad, Ferid

doi:10.1007/s00268-007-0727-3

Cited by 81 publications

(75 citation statements)

References 32 publications

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“…[1,2,[34][35][36] However, to the best of our knowledge, the use of POMs as a carrier for NO storage and delivery has never been reported. Fortunately, according to our previous ESI-MS study [37] on organoimido derivatives of POMs, these compounds are unstable in nearly neutral or basic aqueous solutions.…”

Section: No Release Studymentioning

confidence: 90%

trans‐Dinitrosyl‐Substituted Hexamolybdate and Study of Its Controllable NO Release

et al. 2013

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On the basis of the well-developed N,NЈ-dicyclohexylcarbodiimide (DCC) imidoylization strategy, the novel trans-dinitrosyl-substituted polyoxometalate (POM) (NBu 4 ) 4 -[Mo 6 O 17 (ϵNO) 2 ] was synthesized in moderate yield with high purity through a highly selective reaction route under mild reaction conditions. Its structure was elucidated by IR and UV/Vis spectroscopy, ESI-MS, and single-crystal X-ray diffraction studies. Furthermore, its ability to undergo con-

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Section: No Release Studymentioning

confidence: 90%

trans‐Dinitrosyl‐Substituted Hexamolybdate and Study of Its Controllable NO Release

et al. 2013

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“…Previous reports have indicated that nitric oxide influences cytokines, chemokines, and the infiltration of inflammatory cells to the burn wound [18]. Nitrate/nitrite is a metabolite of NO, and in our previous study in nonburn mice, we found that midazolam significantly attenuated the LPS-induced increase in serum nitrate [8].…”

Section: Midazolam Increased Serum Nitratementioning

confidence: 92%

“…8). A major source of the serum nitrate/nitrite following burn injury reportedly is from the burn wound [18]. We performed real-time RT-PCR to ascertain the mRNA levels of eNOS and iNOS because these are the rate limiting enzymes in the production of NO.…”

Section: Midazolam Increased Serum Nitratementioning

confidence: 99%

The Burn Wound Inflammatory Response Is Influenced by Midazolam

et al. 2011

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Burn patients requiring hospitalization are often treated for anxiety with benzodiazepines (BDZs). Benzodiazepines are reported to influence immune system function. Immune system alterations are a major cause of burn-induced mortality. We wanted to determine whether the BDZ, midazolam given daily at an anxiolytic dose, had any influence on the burn injury-induced inflammatory response in the blood and wound. Mice received a 15% total body surface area flame burn and received either midazolam 1 mg/kg i.p. or saline 0.1 ml daily. Blood and skin wounds were harvested 24 h after injection on post-burn day 2, 3, 7, or 8. Mice treated with midazolam had significantly lower serum IL-1β (p=0.002), TNF-α (p=0.002), IL-6 (p=0.016), IL-10 (p=0.009), and TGF-β (p=0.004) than saline-treated mice, with little impact on serum chemokine levels. In the wound, TNF-α and IL-10 were the only cytokines significantly influenced by the drug, being lower (p=0.018) and higher (p=0.006), respectively. The chemokines in the wound influenced significantly by midazolam were MIP-1α, MIP-1β, and MIP-2 while MCP-1 and KC were not. There were more inflammatory cells at the burn wound margin in midazolam-treated mice on post-burn day 3. Although serum nitrate/nitrite was significantly increased by midazolam (p=0.03), both eNOS and iNOS mRNA expression in the wound were similar to the saline group. We found that midazolam given daily after burn injury significantly influenced the inflammatory response. The clinical implications of these findings on wound healing and shock following burn injury, especially larger burns, deserve further investigation.

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“…6 Indeed, it mediates a number of vital functions, including vasodilatation 7 and re-epithelization. 8 The accumulation of high concentrations of nitric oxide in tumours offers the possibility to increase cancer cells' sensitivity to chemoand radiotherapy or even to suddenly induce their apoptosis. 9 Remarkably, recent studies described the use of NO to enhance cisplatin cytotoxicity in V79 lung fibroblast cells taking advantage from the direct sensitizing of tumour cells.…”

mentioning

confidence: 99%