Nitric oxide as a target for the hypotensive and vasorelaxing effects induced by (Z)-ethyl 12-nitrooxy-octadec-9-enoate in rats

Machado, Natália T.; Maciel, Priscilla Maria Pereira; Alustau, Maria C.; Queiroz, Thyago M.; Furtado, Fabíola Fialho; Assis, Valéria L.; Veras, Robson Cavalcante; Araújo, Islania Giselia Albuquerque; Athayde-Filho, Petrônio Filgueiras de; Medeiros, Isac A.

doi:10.1016/j.ejps.2014.06.012

Cited by 8 publications

(2 citation statements)

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“…Regarding the properties of NO, a large number of NO donor compounds have emerged as potential agents for the treatment of the aforementioned diseases, able to exploit the wide variety of biological functions. Thus, pharmacological aspects of NO are constantly under study [45,[123][124][125][126][127]. Furthermore, administration of drugs that mimic the effect of NO on the organism is an attractive proposal, since this is a pharmacological alternative that could reverse and/or prevent cardiovascular disorders [125].…”

Section: Nitric Oxide Donorsmentioning

confidence: 99%

“…New chemical classes of NO donors have now been synthesized and may have potential for the treatment of CVDs. Our research group and others have studied some new NO donors which induced hypotension in normotensive rats such as (Z)-ethyl 12-nitrooxyoctadec-9-enoate (NCOE) [126] and cis-[Ru(bpy) 2 (py)(NO 2 )](PF 6 ) (RuBPY) [125] as well as in hypertensive animals, for instance 2-nitrate-1,3-dibuthoxypropan (NDBP) [228][229][230], the nitrosyl-ruthenium complex [Ru(terpy)(bdq)NO + ]3 + (TERPY) [231][232][233][234], the cyclohexane nitrate (HEX) [235], and the organic nitrate 1,3-bis (hexyloxy) propan-2-yl nitrate (NDHP) [236] (Table 1).…”

Section: Clinical Use and Limitations Of Nitric Oxide Donorsmentioning

confidence: 99%

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Nitric Oxide as a Central Molecule in Hypertension: Focus on the Vasorelaxant Activity of New Nitric Oxide Donors

Silva

Nascimento

et al. 2021

Biology

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Cardiovascular diseases include all types of disorders related to the heart or blood vessels. High blood pressure is an important risk factor for cardiac complications and pathological disorders. An increase in circulating angiotensin-II is a potent stimulus for the expression of reactive oxygen species and pro-inflammatory cytokines that activate oxidative stress, perpetuating a deleterious effect in hypertension. Studies demonstrate the capacity of NO to prevent platelet or leukocyte activation and adhesion and inhibition of proliferation, as well as to modulate inflammatory or anti-inflammatory reactions and migration of vascular smooth muscle cells. However, in conditions of low availability of NO, such as during hypertension, these processes are impaired. Currently, there is great interest in the development of compounds capable of releasing NO in a modulated and stable way. Accordingly, compounds containing metal ions coupled to NO are being investigated and are widely recognized as having great relevance in the treatment of different diseases. Therefore, the exogenous administration of NO is an attractive and pharmacological alternative in the study and treatment of hypertension. The present review summarizes the role of nitric oxide in hypertension, focusing on the role of new NO donors, particularly the metal-based drugs and their protagonist activity in vascular function.

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