Nitric oxide donor superparamagnetic iron oxide nanoparticles

Molina, María; Seabra, Amedea B.; Oliveira, Marcelo Ganzarolli de; Itri, Rosângela; Haddad, Paula S.

doi:10.1016/j.msec.2012.10.027

Cited by 50 publications

(38 citation statements)

References 41 publications

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“…Seabra et al reported the synthesis, characterization, cytotoxicity, and genotoxicity of iron oxide (Fe 3 O 4 ) magnetic nanoparticles coated with mercaptosuccinic acid (MSA) and dimercaptosuccinic acid (DMSA) [77][78][79][80]. The thiol groups on the surface of Fe 3 O 4 nanoparticles were nitrosated, yielding S-nitrosated nanoparticles, which act as spontaneous NO donors.…”

Section: Metallic Nanoparticlesmentioning

confidence: 99%

“…Upon incubation with healthy cells (human lymphocytes, 3T3 fibroblasts) and human breast cancer cells (MCF-7), concentration-and time-dependent cytotoxicity and genotoxicity were observed [78][79][80]. As NO-releasing Fe 3 O 4 nanoparticles are superparamagnetic at room temperature [77], upon systemic application, these nanoparticles can be guided directly to the tumor cells (desired site of application) upon application of an external magnetic field. Thus, sitespecific NO release to tumor cells may be modulated by controlling the external magnetic field, minimizing undesired NO release from the iron-based nanoparticles into healthy tissues.…”

Section: Metallic Nanoparticlesmentioning

confidence: 99%

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Nitric Oxide Releasing Nanomaterials for Cancer Treatment: Current Status and Perspectives

Seabra¹,

Lima²,

Calderón

2015

CTMC

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Nitric oxide (NO) is known to have dichotomous effects on cancer biology, acting as a pro- or antineoplastic agent. Low concentrations of NO are reported to promote tumor growth, whereas high NO influx acts as a potent tumor repressor, leading to cytotoxicity and apoptosis. There is increasing interest in developing NO-releasing materials as potent tumoricidal agents in which high and localized concentrations of NO may be directly released in a sustained manner to the tumor site. Nanomaterials allied to NO donors have emerged as a promising strategy in cancer treatment. In this context, this review summarizes the roles of NO in cancer biology and highlights the therapeutic potential effects of NO-releasing nanomaterials based on polymeric nanoparticles, dendritic polymers, liposomes, silica nanoparticles, metallic nanoparticles and quantum dots in combating tumor cells.

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Section: Metallic Nanoparticlesmentioning

confidence: 99%

Section: Metallic Nanoparticlesmentioning

confidence: 99%

Nitric Oxide Releasing Nanomaterials for Cancer Treatment: Current Status and Perspectives

Seabra¹,

Lima²,

Calderón

2015

CTMC

View full text Add to dashboard Cite

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“…Devido a seu pequeno tamanho, sua falta de carga e alta lipolicidade, NO é uma molécula altamente difusível através de membranas celulares para agir com alvos intracelulares [38].…”

Section: 5)unclassified

“…Como reportado anteriormente na literatura para moléculas de S-nitrosotióis (R-SNO) de baixo peso molecular, como a S-glutationa (GSNO), os grupos S-NO sofrem clivagem homolítica, liberando-se assim NO (Equações 4.1 e 4.2) [29]. Os produtos de decomposição depois da liberação de NO são dímeros de MSA ligados através de ponte disulfeto, de acordo com as reações [38]:…”

Section: Segunda Etapaunclassified

“…onde NP-MSA-SNO representa a molécula adsorvida de ácido mercaptosuccínico nitrosado sobre a superfície das NPs, enquanto NP-MSA-S · representa o radical thiil formado após a ruptura homolítica da ligação S-N, e os dimeros resultantes NP-MSA-S-S-MSA-NP são esperados permanecer adsorvidos na superfície das NPs [38]. Embora desorção dos dímeros não possa ser desconsiderada, sua ocorrência deve ser pequena devido à adsorção estabelecida entre os grupos carboxila do MSA e a superfície do óxido de ferro.…”

Section: Segunda Etapaunclassified

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Síntese e caracterização de nanopartículas magnéticas: Aplicação como vetores de liberação de óxido nítrico

Molina¹

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Polymeric Nitric Oxide Delivery Nanoplatforms for Treating Cancer, Cardiovascular Diseases, and Infection

Jin

Gao

Liu

et al. 2020

Adv Healthcare Materials

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The shortened Abstract is as follows: Therapeutic gas nitric oxide (NO) has demonstrated the unique advances in biomedical applications due to its prominent role in regulating physiological/pathophysiological activities in terms of vasodilation, angiogenesis, chemosensitizing effect, and bactericidal effect. However, it is challenging to deliver NO, due to its short half-life (<5 s) and short diffusion distances (20-160 µm). To address these, various polymeric NO delivery nanoplatforms (PNODNPs) have been developed for cancer therapy, antimicrobial and cardiovascular therapeutics, because of the important advantages of polymeric delivery nanoplatforms in terms of controlled release of therapeutics and the extremely versatile nature. This reviews highlights the recent significant advances made in PNODNPs for NO storing and targeting delivery. The ideal and unique criteria that are required for PNODNPs for treating cancer, cardiovascular diseases and infection, respectively, are summarized. Hopefully, effective storage and targeted delivery of NO in a controlled manner using PNODNPs could pave the way for NO-sensitized synergistic therapy in clinical practice for treating the leading death-causing diseases.

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Nitric oxide donor superparamagnetic iron oxide nanoparticles

Cited by 50 publications

References 41 publications

Nitric Oxide Releasing Nanomaterials for Cancer Treatment: Current Status and Perspectives

Nitric Oxide Releasing Nanomaterials for Cancer Treatment: Current Status and Perspectives

Síntese e caracterização de nanopartículas magnéticas: Aplicação como vetores de liberação de óxido nítrico

Polymeric Nitric Oxide Delivery Nanoplatforms for Treating Cancer, Cardiovascular Diseases, and Infection

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