Nitric oxide in human gingival crevicular fluid after orthodontic force application

Ford, Heather; Suri, Sunjay; Nilforoushan, Dorrin; Manolson, Morris F.; Gong, Siew‐Ging

doi:10.1016/j.archoralbio.2014.07.015

Cited by 11 publications

(14 citation statements)

References 35 publications

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“…Osteoblasts and osteoclasts both secrete NO, which has autocrine and paracrine effects and is involved in the regulation of osteoblasts and osteoclasts ( 22 ). NOS and NO display bidirectional regulation of osteoclast function ( 23 ). A basal concentration of NO is essential for maintaining the normal resorption activity of osteoclasts; however, when the concentration of NO increases above a certain threshold, it may significantly increase the resorption activity of osteoclasts by stimulating the activity of cyclic guanosine monophosphate to induce cytotoxicity ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Salvianolic acid B and danshensu induce osteogenic differentiation of rat bone marrow stromal stem cells by upregulating the nitric oxide pathway

Zhang

Zou

Jin

et al. 2017

Experimental and Therapeutic Medicine

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The aim of the present study was to investigate the effect of salvianolic acid B (Sal B) and danshensu (DSU) on the osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs) and the mechanisms of the effects. The osteogenic differentiation of MSCs in culture was assessed by measuring alkaline phosphatase (ALP) activity, osteocalcin (OCN) production, nitric oxide (NO) production and the mRNA expression levels of osteoprotegerin (OPG) and its ligand by MSCs. MSCs were successfully induced to differentiate into osteoblasts and adipocytes. Sal B and DSU increased the ALP activity and the production of OCN in the absence of an ossification inducer. The increase in ALP activity was more pronounced when induction was combined with the osteogenic inducer, Sal B, which enhanced the expression of OPG; however, Sal B reduced the expression of receptor activator of nuclear factor-κB ligand (RANKL) by MSCs. Sal B reversed the inhibitory effect of N-nitro L-arginine methylester on the MSCs and increased ALP activity, OCN content and the OPG/RANKL ratio. Based on these results, it was concluded that Sal B increases the osteogenic differentiation of MSCs, most likely by regulating the nitric oxide pathway.

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Section: Discussionmentioning

confidence: 99%

Salvianolic acid B and danshensu induce osteogenic differentiation of rat bone marrow stromal stem cells by upregulating the nitric oxide pathway

Zhang

Zou

Jin

et al. 2017

Experimental and Therapeutic Medicine

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“…A variety of biomarkers in gingival crevicular fluid (GCF) are often analyzed, in order to facilitate the improvement of clinical treatment. In various studies, many of which recent, it has been mentioned that NO expression levels in GCF is related to orthodontic treatment (203)(204)(205)(206). Ford et al (203) revealed that NO concentration in GCF on the compression side of the central incisor increased significantly 1 h after the application of fixed orthodontic appliances.…”

Section: Osteoclastsmentioning

confidence: 99%

Role of nitric oxide in orthodontic tooth movement (Review)

Yan

Xie

et al. 2021

Int J Mol Med

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Nitric oxide (NO) is an ubiquitous signaling molecule that mediates numerous cellular processes associated with cardiovascular, nervous and immune systems. NO also plays an essential role in bone homeostasis regulation. The present review article summarized the effects of NO on bone metabolism during orthodontic tooth movement in order to provide insight into the regulatory role of NO in orthodontic tooth movement. Orthodontic tooth movement is a process in which the periodontal tissue and alveolar bone are reconstructed due to the effect of orthodontic forces. Accumulating evidence has indicated that NO and its downstream signaling molecule, cyclic guanosine monophosphate (cGMP), mediate the mechanical signals during orthodontic-related bone remodeling, and exert complex effects on osteogenesis and osteoclastogenesis. NO has a regulatory effect on the cellular activities and functional states of osteoclasts, osteocytes and periodontal ligament fibroblasts involved in orthodontic tooth movement. Variations of NO synthase (NOS) expression levels and NO production in periodontal tissues or gingival crevicular fluid (GCF) have been found on the tension and compression sides during tooth movement in both orthodontic animal models and patients. Furthermore, NO precursor and NOS inhibitor administration increased and reduced the tooth movement in animal models, respectively. Further research is required in order to further elucidate the underlying mechanisms and the clinical application prospect of NO in orthodontic tooth movement.

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“…NO, ortodontik diş hareketinde etkili, kısa yarı ömürlü, yüksek oranda reaktif bir serbest radikaldir (70). İkincil haberci oluşumunda, osteoblast ve osteoklast fonksiyonunda ve pulpal kan akımının düzenlenmesinde görev alır (14).…”

Section: Nitrik Oksitunclassified

“…Ortodontik diş hareketi oluşumunda gerilmeden kısa bir süre sonra osteoblast ve osteositlerden salgılanır. Çalışmalarda NO'nun ortodontik diş hareketi sırasında gerekli olduğu ve NO uygulanan çalışma gruplarında ortodontik diş hareketi hızının arttığı gösterilmiştir (70,71).…”

Section: Nitrik Oksitunclassified

Endogenous and Exogenous Substances Influencing the Orthodontic Tooth Movement

Cesur¹,

Beygirci²

2016

meandros

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Ortodontik diş hareketi kontrollü mekanik kuvvetlerin sürekli uygulanması sonucu gerçekleşmektedir. Son zamanlarda yapılan çalışmalar mekanik kuvvetlerin yanı sıra, sistemik veya lokal ilaç uygulamaları ile diyet takviyelerinin etkileri üzerine odaklanmıştır. Ortodontik diş hareketini etkileyen bu maddeler paratiroid hormon, tiroid hormonları, eikozanoidler, nonsteroid anti-enflamatuvar ilaçlar (NSAİ), parasetamol, kortikosteroidler, bifosfonatlar, kolesterol ilaçları, antikonvülsanlar, oral kontraseptifler, alkol ve nikotin, nitrik oksit ve fluoriddir. Bu medikal ajanların ortodontik diş hareketi hızı ve tedavi süresi üzerine önemli etkileri vardır. NSAİ diş hareketini azaltırken, parasetamolun herhangi bir etkisi bulunmamaktadır. Paratiroid ve tiroksin hormonları diş hareketini arttırmaktadır. Bifosfonatlar güçlü bir inhibe edici etkiye sahiptir. Vitamin D3 diş hareketini stimüle ederken, diyetle alınan kalsiyum ise azaltmaktadır. Ortodontik tedavi sırasında bu maddelerin tüketimi hakkında hastalar ile görüşülmesi önemlidir. Orthodontic tooth movement occurs as a result of prolonged application of controlled mechanical forces. Recent studies have focused on the effects of systemic or local applications of medications and the intake of dietary supplements as well as the mechanical forces. Factors affecting the orthodontic tooth movement are parathyroid hormone, thyroid hormones, estrogen, vitamin D3, eicosanoids, nonsteroidal anti-inflammatory drugs (NSAIDs), paracetamol, corticosteroids, bisphosphonates, cholesterol drugs, anticonvulsants, oral contraceptives, alcohol and nicotine use, nitric oxide, and fluoride. These medications have an important effect on the rate of tooth movement and treatment time. NSAIDs decrease tooth movement, but paracetamol has no effect. Parathyroid and thyroxin hormones increase tooth movement. Bisphosphonates have a strong inhibitory effect. Vitamin D3 stimulates tooth movement and dietary calcium seems to reduce it. It is important to discuss with patients about the consumption of these substances during orthodontic treatment.

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Nitric oxide in human gingival crevicular fluid after orthodontic force application

Cited by 11 publications

References 35 publications

Salvianolic acid B and danshensu induce osteogenic differentiation of rat bone marrow stromal stem cells by upregulating the nitric oxide pathway

Salvianolic acid B and danshensu induce osteogenic differentiation of rat bone marrow stromal stem cells by upregulating the nitric oxide pathway

Role of nitric oxide in orthodontic tooth movement (Review)

Endogenous and Exogenous Substances Influencing the Orthodontic Tooth Movement

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