Nitric oxide involvement in consolidation, but not retrieval phase of cognitive performance enhanced by atorvastatin in mice

Rayatnia, Farhoud; Javadi‐Paydar, Mehrak; Allami, Nika; Zakeri, Marjan; Rastegar, Hossein; Norouzi, Abbas; Dehpour, Ahmad Reza

doi:10.1016/j.ejphar.2011.05.017

Cited by 14 publications

(14 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been shown that atorvastatin is able to promote improvement in the consolidation and retrieval phases of memory [21]. Moreover, atorvastatin (5 mg/kg) is also able to protect the deficit in the spatial recognition performance in mice treated with scopolamine [21].…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Statins enhance cognitive performance in object location test in albino Swiss mice: Involvement of beta-adrenoceptors

Vandresen-Filho

França

Alcantara-Junior

et al. 2015

Physiology & Behavior

View full text Add to dashboard Cite

Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, thereby inhibiting cell synthesis of cholesterol and isoprenoids. Moreover, several studies have been evaluating pleiotropic effects of statins, mainly because they present neuroprotective effects in various pathological conditions. However, knowledge about behavioral effects of statins per se is relatively scarce. Considering these facts, we aimed to analyze behavioral responses of atorvastatin or simvastatin-treated mice in the open field test, elevated plus maze and object location test. Atorvastatin treatment for 7 consecutive days at 1 mg/kg or 10 mg/kg (v.o.) or simvastatin 10 mg/kg or 20 mg/kg enhanced cognitive performance in object location test when compared to control group (saline-treated mice). Simvastatin effects on mice performance in the object location test was abolished by post-training infusion of the beta-adrenoceptor antagonist propranolol. Atorvastatin and simvastatin did not change the behavioral response in open field and elevated plus-maze (EPM) tests in any of the used doses. These data demonstrate the positive effects of both statins in cognitive processes in mice, without any alteration in locomotor parameters in the open field test or anxiolytic-like behavior in EPM. In conclusion, we demonstrate that atorvastatin and simvastatin per se improve the cognitive performance in a rodent model of spatial memory and this effect is related to beta-adrenergic receptors modulation.

show abstract

Section: Discussionmentioning

confidence: 98%

“…It has been demonstrated that treatment with statins prevented spatial memory deficit induced by traumatic brain injury or scopolamine infusion in rodents [15,20,21]. Statin treatment has also been shown to prevent neuronal cell death as well to prevent cognitive deficits induced by Aβ infusion [22,23].…”

Section: H I G H L I G H T Smentioning

confidence: 99%

Statins enhance cognitive performance in object location test in albino Swiss mice: Involvement of beta-adrenoceptors

Vandresen-Filho

França

Alcantara-Junior

et al. 2015

Physiology & Behavior

View full text Add to dashboard Cite

show abstract

“…It has been indicated that AG has not changed the recovering result of pioglitazone on morphine-induced passive avoidance task defi ciency but has reduced the improving effect of pioglitazone on Y-maze discrimination defi ciency result from morphine (21). Also, the benefi cial effects of either atorvastatin or granisetron on memory consolidation defi ciency due to scopolamine have been combated by AG in mice (20,22). However, no study has been published regarding the effect of chronic or subchronic ip administration of AG on PAL and apoptosis in the hippocampus of diabetic animals.…”

Section: Discussionmentioning

confidence: 99%

“…Protective effects of AG have been shown in peripheral nerves' functional and structural defi cits induced by DM (11) and transient focal cerebral ischemia (12) and stroke (13). Paradoxical results are available relating to the effect of AG on memory of animals including positive (14)(15)(16)(17)(18) and negative effects (19)(20)(21)(22). To our knowledge, few studies have been published concerning the effect of ip administration of AG on memory and anti/apoptotic genes in diabetic animals.…”

Section: Introductionmentioning

confidence: 99%

Effect of sub-chronic intraperitoneal administration of aminoguanidine on the memory and hippocampal apoptosis-related genes in diabetic rats

Alipour¹,

Amini²,

Adineh³

et al. 2016

BLL

View full text Add to dashboard Cite

Memory impairment is a common disorder in diabetes mellitus which is associated with hippocampal neuronal apoptosis. The present study was conducted to examine the effect of one-week intraperitoneal (ip), administration of aminoguanidine (AG) on passive avoidance learning (PAL) and Bcl-2 family gene expression in the hippocampus of rats. Sixty male rats were divided into ten groups: non-diabetic/diabetic animals with/without AG (50, 100, 200 and 400 mg/kg, ip) treatment for one week. PAL and Bcl-2 family genes were examined. AG (100 and 200 mg/kg) improved both memory and Bax, Bak, Bcl-2 and Bcl-xl defi ciency signifi cantly in diabetic rats. AG treatment also ameliorated the diabetes-induced changes in (Bcl-2+Bcl-xl)/(Bak+Bax) ratios considerably. These results propose that one-week ip administration of AG may recover the defi cit cognition in diabetic rats via enhancing (Bcl-2+Bcl-xl)/(Bak+Bax) proportions (Tab. 2, Fig. 4, Ref. 55). Text in PDF www.elis.sk.

show abstract

“…l-Arginine is the substrate for the NOS enzymes. Several studies had shown that the level of l-arginine decreases in old age and in AD (Yi et al, 2009) and that its increase is responsible for improving memory (Rayatnia et al, 2011;Yildiz Akar et al, 2009).…”

Section: Introductionmentioning

confidence: 98%

Overexpression of NMDAR2B in an inflammatory model of Alzheimer's disease: Modulation by NOS inhibitors

Maher

Sayed

Breitinger

2014

Brain Research Bulletin

View full text Add to dashboard Cite

Nitric oxide involvement in consolidation, but not retrieval phase of cognitive performance enhanced by atorvastatin in mice

Cited by 14 publications

References 55 publications

Statins enhance cognitive performance in object location test in albino Swiss mice: Involvement of beta-adrenoceptors

Statins enhance cognitive performance in object location test in albino Swiss mice: Involvement of beta-adrenoceptors

Effect of sub-chronic intraperitoneal administration of aminoguanidine on the memory and hippocampal apoptosis-related genes in diabetic rats

Overexpression of NMDAR2B in an inflammatory model of Alzheimer's disease: Modulation by NOS inhibitors

Contact Info

Product

Resources

About