Nitric oxide metabolite levels in preterm labor

Chadha, Sandeep; Jain, Vanita; Gupta, Indu; Khullar, Madhu

doi:10.1111/j.1447-0756.2007.00639.x

Cited by 12 publications

(11 citation statements)

References 30 publications

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“…In this context, the combination of these 3 factors to create a prediction model for PTD gives appreciable meaning to the present study, as demonstrated by the diagnostic accuracy of the model. Both the current study and previously published studies [15,21] excluded women with signs of chorioamnionitis; however, on multivariate analysis, the presence of genital infection was not associated with PTD. The published data on the role of infection in PTL seem to be inconsistent.…”

Section: Discussioncontrasting

confidence: 64%

“…Many studies have shown that decreased levels of cervical NOx are associated with post-term pregnancy [16], whereas elevated levels of cervical, plasma, and urinary NOx are associated with PTL [15,[18][19][20]. However, to date, only 1 study has assessed the potential value of vaginal NOx level as a predictive factor for PTD-with elevated vaginal NOx levels associated with preterm birth [10].…”

Section: Discussionmentioning

confidence: 95%

“…Chadha et al [15] showed that serum and urinary nitrite levels were higher in patients with PTL and preterm premature rupture of membranes than in women with physiologic development of pregnancy. They also found that serum and urinary nitrite levels were higher in women with PTD than in women who delivered at term.…”

Section: Discussionmentioning

confidence: 98%

“…Given that NOx can activate matrix metalloproteinases [11,12] and induce apoptotic cell death [13,14], overproduction of NOx could be involved in cervical ripening, fragility of membranes, and subsequent premature delivery. In addition, elevated plasma NOx levels have been reported to show an association with PTL and PTD [15].…”

Section: Introductionmentioning

confidence: 97%

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Nitric oxide metabolite levels and assessment of cervical length in the prediction of preterm delivery among women undergoing symptomatic preterm labor

Giannella¹,

Beraldi

Giulini

et al. 2011

Intl J Gynecology & Obste

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Objective: To evaluate the diagnostic accuracy of measuring cervical length (CL) in combination with cervical and plasma nitric oxide metabolite (NOx) levels to identify women undergoing preterm labor (PTL) who will deliver preterm. Methods: A hospital-based prospective cohort study of 730 women undergoing spontaneous PTL between 24 and 33 weeks + 6 days of pregnancy was conducted. Measurement of cervical and plasma NOx levels and ultrasonographic assessment of CL were performed to find the best model to predict preterm delivery (PTD). Optimal cut-off values were calculated by receiver operating characteristic (ROC) curve analysis. Logistic regression analysis and rank correlation tests were also performed. Results: CL of 15 mm or less, cervical NOx levels greater than 87.6 μmol/L, and plasma NOx levels greater than 123 μmol/L (P b 0.0001) were the only factors significantly associated with PTD within 7 days of sampling. This combined model provided high diagnostic accuracy (sensitivity 80.0%; specificity 99.2%). Both cervical and plasma NOx levels were negatively correlated with CL (r = − 0.453, P b 0.0001 and r = − 0.362, P b 0.0001, respectively). Conclusion: Combined measurement of CL and levels of cervical and plasma NOx could help identify women undergoing symptomatic PTL who are at increased risk of PTD.

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Section: Discussioncontrasting

confidence: 64%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 97%

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Nitric oxide metabolite levels and assessment of cervical length in the prediction of preterm delivery among women undergoing symptomatic preterm labor

Giannella¹,

Beraldi

Giulini

et al. 2011

Intl J Gynecology & Obste

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“…Inflammation induces the up-regulation of ROS and can cause overt OS, resulting in tissue injury and subsequent preterm labor [249]. The concentration of Mn-SOD increases as a protective response to inflammation and OS, and down-regulates NF-kappa B, activator protein-1, and MAPK pathways [250].…”

Section: Pregnancy Complicationsmentioning

confidence: 99%

The effects of oxidative stress on female reproduction: a review

Agarwal

Aponte-Mellado

Premkumar

et al. 2012

Reprod Biol Endocrinol

1,441

1,188

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Oxidative stress (OS), a state characterized by an imbalance between pro-oxidant molecules including reactive oxygen and nitrogen species, and antioxidant defenses, has been identified to play a key role in the pathogenesis of subfertility in both males and females. The adverse effects of OS on sperm quality and functions have been well documented. In females, on the other hand, the impact of OS on oocytes and reproductive functions remains unclear. This imbalance between pro-oxidants and antioxidants can lead to a number of reproductive diseases such as endometriosis, polycystic ovary syndrome (PCOS), and unexplained infertility. Pregnancy complications such as spontaneous abortion, recurrent pregnancy loss, and preeclampsia, can also develop in response to OS. Studies have shown that extremes of body weight and lifestyle factors such as cigarette smoking, alcohol use, and recreational drug use can promote excess free radical production, which could affect fertility. Exposures to environmental pollutants are of increasing concern, as they too have been found to trigger oxidative states, possibly contributing to female infertility. This article will review the currently available literature on the roles of reactive species and OS in both normal and abnormal reproductive physiological processes. Antioxidant supplementation may be effective in controlling the production of ROS and continues to be explored as a potential strategy to overcome reproductive disorders associated with infertility. However, investigations conducted to date have been through animal or in vitro studies, which have produced largely conflicting results. The impact of OS on assisted reproductive techniques (ART) will be addressed, in addition to the possible benefits of antioxidant supplementation of ART culture media to increase the likelihood for ART success. Future randomized controlled clinical trials on humans are necessary to elucidate the precise mechanisms through which OS affects female reproductive abilities, and will facilitate further explorations of the possible benefits of antioxidants to treat infertility.

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Progesterone modulates the LPS-induced nitric oxide production by a progesterone-receptor independent mechanism

Wolfson

Schander

Bariani

et al. 2015

European Journal of Pharmacology

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Nitric oxide metabolite levels in preterm labor

Abstract: Higher nitric oxide metabolites in women with preterm labor are marker of subclinical infection.

Cited by 12 publications

References 30 publications

Nitric oxide metabolite levels and assessment of cervical length in the prediction of preterm delivery among women undergoing symptomatic preterm labor

Nitric oxide metabolite levels and assessment of cervical length in the prediction of preterm delivery among women undergoing symptomatic preterm labor

The effects of oxidative stress on female reproduction: a review

Progesterone modulates the LPS-induced nitric oxide production by a progesterone-receptor independent mechanism

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