Nitric oxide metabolites in the urine of full‐term and preterm infants

Dzik, Jolanta M.; Dobrzańska, Anna; Gruszfeld, Dariusz; Wałajtys-Rode, Elżbieta

doi:10.1046/j.1442-200x.2002.01584.x

Cited by 8 publications

(6 citation statements)

References 43 publications

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“…However, more rigorous studies need to be done to validate nitrite as a reliable marker for NEC. While the cause of this increase cannot be determined from the present study, it is worth noting that similar increases in urinary nitrite and/or nitrate are found in infants with systemic inflammatory responses (38), consistent with markedly increased iNOS activity.…”

Section: Discussionsupporting

confidence: 76%

Changes in plasma and urinary nitrite after birth in premature infants at risk for necrotizing enterocolitis

et al. 2015

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Background Plasma nitrite serves as a reservoir of nitric oxide (NO) bioactivity. Because nitrite ingestion is markedly lower in newborns than adults, we hypothesized plasma nitrite levels would be lower in newborns than in adults, and that infants diagnosed with necrotizing enterocolitis (NEC), a disease characterized by ischemia and bacterial invasion of intestinal walls, would have lower levels of circulating nitrite in the days prior to diagnosis. Methods Single blood and urine samples were collected from 9 term infants and 12 adults, 72 preterm infants every 5 d for 3 wk, and from 13 lambs before and after cord occlusion. Results Nitrite fell 50% relative to cord levels in the first day after birth; and within 15 min after cord occlusion in lambs. Urinary nitrite was higher in infants than adults. Plasma and urinary nitrite levels in infants who developed NEC were similar to those of preterm control infants on days 1 and 5, but significantly elevated at 15 and 20 d after birth. Conclusion Plasma nitrite falls dramatically at birth while newborn urinary nitrite levels are significantly greater than adults. Acute NEC is associated with elevated plasma and urinary nitrite levels.

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Section: Discussionsupporting

confidence: 76%

Changes in plasma and urinary nitrite after birth in premature infants at risk for necrotizing enterocolitis

et al. 2015

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“…However, studies in experimental animals reveal that iNOS upregulation and production of NO may have a feedback inhibition on constitutive NO production in other tissues [21, 72]. Urinary NOx reflects both the production and utilization of NO [73, 74]. Nitrate is the main urinary NO metabolite, whereas nitrite is low to undetectable in urine [75].…”

Section: No and Its Metabolites In Acute Disease Processesmentioning

confidence: 99%

Nitric Oxide and its Metabolites in the Critical Phase of Illness: Rapid Biomarkers in the Making

Mian

Aranke²,

Bryan

2013

Open Biochem J

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The potential of nitric oxide (NO) as a rapid assay biomarker, one that could provide a quantum leap in acute care, remains largely untapped. NO plays a crucial role as bronchodilator, vasodilator and inflammatory mediator. The main objective of this review is to demonstrate how NO is a molecule of heavy interest in various acute disease states along the emergency department and critical care spectrum: respiratory infections, central nervous system infections, asthma, acute kidney injury, sepsis, septic shock, and myocardial ischemia, to name just a few. We discuss how NO and its oxidative metabolites, nitrite and nitrate, are readily detectable in several body compartments and fluids, and as such they are associated with many of the pathophysiological processes mentioned above. With methods such as high performance liquid chromatography and chemiluminescence these entities are relatively easy and inexpensive to analyze. Emphasis is placed on diagnostic rapidity, as this relates directly to quality of care in acute care situations. Further, a rationale is provided for more bench, translational and clinical research in the field of NO biomarkers for such settings. Developing standard protocols for the aforementioned disease states, centered on concentrations of NO and its metabolites, can prove to revolutionize diagnostics and prognostication along a spectrum of clinical care. We present a strong case for developing these biomarkers more as point-of-care assays with potential of color gradient test strips for rapid screening of disease entities in acute care and beyond. This will be relevant to global health.

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“…Dzik et al [39] found NO production was elevated in the perinatal period, particularly in preterm infants and they had the highest concentrations of ADMA.…”

Section: Discussionmentioning

confidence: 98%

Plasma Asymmetric Dimethylarginine Levels in Neonates with Bronchopulmonary Dysplasia Associated with Pulmonary Hypertension

Meneza¹,

Bahgat²,

Nasr³

2018

OJPed

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Background: Bronchopulmonary dysplasia (BPD) continues to be an important problem in neonates especially premature infants despite improved facilities of care, monitoring and treatment. Pulmonary hypertension (PH) is a major complicating factor and key cause of mortality in this population. Altered vascular and alveolar growth particularly in canalicular and early saccular stages of lung development following mechanical ventilation and oxygen therapy result in arrest of the lung development leading to BPD with PH. Early recognition of PH in infants with these risk factors is important for optimal management. We tested the hypothesis that asymmetric dimethylarginine, would be greater in infants with bronchopulmonary dysplasia associated pulmonary hypertension than in infants with BPD alone. The Aim: The aim of the current study was to measure the Asymmetric dimethylarginine (ADMA) levels, arginine levels & the plasma arginine-to-ADMA ratio in newborn infants with broncho-pulmonary dysplasia, to evaluate echocardiographic parameters among neonates with bronchopulmonary dysplasia, to correlate between plasma ADMA & arginine-to-ADMA ratio and echocardiographic (ECHO) parameters in those patients and to compare full term & preterm neonates with bronchopulmonary dysplasia as regard to plasma ADMA level. Methods: A case-control study was carried out of ninety (90) newborns selected from those admitted to Neonatal Intensive Care Unit at Maternity & Children Hospital and Alzhraa University hospital during the period from October 2015 to March 2018. Neonates were divided into 2 groups: Patient with BPD with PH (cases group): It included 45 neonates with BPD & PH, 35 preterm neonates and 10 full term neonates. Patient with BPD only (Control group): It included 45 neonates with BPD without PH. These 45 neonates were divided as 22 preterm neonates and 23 full term neonates.

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Nitric oxide metabolites in the urine of full‐term and preterm infants

Abstract: The results indicate urinary NOx level is lowered in infants with life-threatening generalized infection. A possibility of a rapid test based on newborn urinary NOx level determination is considered.

Cited by 8 publications

References 43 publications

Changes in plasma and urinary nitrite after birth in premature infants at risk for necrotizing enterocolitis

Changes in plasma and urinary nitrite after birth in premature infants at risk for necrotizing enterocolitis

Nitric Oxide and its Metabolites in the Critical Phase of Illness: Rapid Biomarkers in the Making

Plasma Asymmetric Dimethylarginine Levels in Neonates with Bronchopulmonary Dysplasia Associated with Pulmonary Hypertension

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