Nitric oxide modulates intracellular translocation of pigment organelles inXenopus laevis melanophores

Nilsson, Harriet M.; Karlsson, Annika M.; Loitto, Vesa-Matti; Svensson, Samuel; Sundqvist, Tommy

doi:10.1002/1097-0169(200011)47:3<209::aid-cm4>3.0.co;2-w

Cited by 13 publications

(11 citation statements)

References 26 publications

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“…Working on the same amphibian species, Nilsson et al (2000) further noted that an inhibitor of NO synthesis, L-NAME, reduced the melatonin-induced aggregation of melanosomes. They concluded that NO may activate soluble guanylyl cyclase, which would lead to increased production of cGMP and activation of cGMPdependent kinases, resulting in the aggregation of melanosomes.…”

Section: Discussionmentioning

confidence: 99%

“…Based on their results that an inhibitor of NO synthesis, Nω-nitro-L-arginine methyl ester (L-NAME) reduced the mel-atonin-induced aggregation of melanosomes, Nilsson et al (2000) recently reported that NO may play a role in the aggregation of pigment in melanophores of the African clawed toad, Xenopus laevis. Using teleostean species, we have also examined the possible role of NO in signaling the motile responses of chromatophores.…”

Section: Introductionmentioning

confidence: 99%

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Possible Involvement of Nitric Oxide in Signaling Pigment Dispersion in Teleostean Melanophores

Hayashi

Fujii

2001

Zoological Science

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Possible Involvement of Nitric Oxide in Signaling Pigment Dispersion in Teleostean Melanophores

Hayashi

Fujii

2001

Zoological Science

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“…In chromatophores of the palaemonid shrimps P. vulgaris , (Fingerman, ) and M. potiuna (Nery et al., ), FSK likewise induces pigment dispersion in the presence of RPCH. It also inhibits aggregation and accelerates dispersion in the black and red chromatophores of teleosts ( Grahamina capito , Nilsson et al., ). VNP, an inhibitor of Ca 2+ /calmodulin‐dependent phosphodiesterase, partially inhibited RPCH‐induced pigment aggregation in M. olfersi chromatosomes.…”

Section: Discussionmentioning

confidence: 99%

Pigment Translocation in Caridean Shrimp Chromatophores: Receptor Type, Signal Transduction, Second Messengers, and Cross Talk Among Multiple Signaling Cascades

et al. 2016

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Pigment aggregation in shrimp chromatophores is triggered by red pigment concentrating hormone (RPCH), a neurosecretory peptide whose plasma membrane receptor may be a G-protein coupled receptor (GPCR). While RPCH binding activates the Ca /cGMP signaling cascades, a role for cyclic AMP (cAMP) in pigment aggregation is obscure, as are the steps governing Ca release from the smooth endoplasmic reticulum (SER). A role for the antagonistic neuropeptide, pigment dispersing homone (α-PDH) is also unclear. In red, ovarian chromatophores from the freshwater shrimp Macrobrachium olfersi, we show that a G-protein antagonist (AntPG) strongly inhibits RPCH-triggered pigment aggregation, suggesting that RPCH binds to a GPCR, activating an inhibitory G-protein. Decreasing cAMP levels may cue pigment aggregation, since cytosolic cAMP titers, when augmented by cholera toxin, forskolin or vinpocentine, completely or partially impair pigment aggregation. Triggering opposing Ca /cGMP and cAMP cascades by simultaneous perfusion with lipid-soluble cyclic nucleotide analogs induces a "tug-of-war" response, pigments aggregating in some chromatosomes with unpredictable, oscillatory movements in others. Inhibition of cAMP-dependent protein kinase accelerates aggregation and reduces dispersion velocities, suggesting a role in phosphorylation events, possibly regulating SER Ca release and pigment aggregation. The second messengers IP and cADPR do not stimulate SER Ca release. α-PDH does not sustain pigment dispersion, suggesting that pigment translocation in caridean chromatophores may be regulated solely by RPCH, since PDH is not required. We propose a working hypothesis to further unravel key steps in the mechanisms of pigment translocation within crustacean chromatophores that have remained obscure for nearly a century.

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“…NO has been shown to affect cellular functions by means of activation of soluble guanylate cyclase, leading to an increase in the cGMP production and inactivation of phospholipase C, which would decrease intracellular concentration of Ca 2? (Nilsson et al 2000).…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that the NO causes aggregation of melanophores in frog, Xenopus laevis (Nilsson et al 2000), whereas it is responsible for the pigment dispersion in fish, Zacco temminicki and Kryptopterus bicirrhis (Hayashi and Fujii 2001) and crab Chasmagnathus granulates (Vargas et al 2008). The results of these studies are contradictory to each other, which indicate that NO has both excitatory and inhibitory effect on coloration of the pigments in frog and fish, respectively.…”

Section: Introductionmentioning

confidence: 99%

Nitric oxide inhibited the melanophore aggregation induced by extracellular calcium concentration in snakehead fish, Channa punctatus

Biswas

Palande

Jadhao

2011

Fish Physiol Biochem

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We studied the role of nitric oxide (NO) and extra-cellular Ca(2+) on the melanophores in Indian snakehead teleost, Channa punctatus. Increase of Ca(2+) level in the external medium causes pigment aggregation in melanophores. This pigment-aggregating effect was found to be inhibited when the external medium contained spontaneous NO donor, sodium nitro prusside (SNP) at all the levels of concentration tested. Furthermore, it has been observed that SNP keeps the pigment in dispersed state even after increasing the amount of Ca(2+). In order to test whether NO donor SNP causes dispersion of pigments or not is checked by adding the inhibitor of nitric oxide synthase, N-omega-Nitro-L-arginine (L-NNA) in the medium. It has been noted that the inhibitor L-NNA blocked the effect of NO donor SNP causing aggregation of pigments. In that way NO is inhibiting the effect of extracellular Ca(2+), keeping the pigment dispersed.

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Nitric oxide modulates intracellular translocation of pigment organelles inXenopus laevis melanophores

Cited by 13 publications

References 26 publications

Possible Involvement of Nitric Oxide in Signaling Pigment Dispersion in Teleostean Melanophores

Possible Involvement of Nitric Oxide in Signaling Pigment Dispersion in Teleostean Melanophores

Pigment Translocation in Caridean Shrimp Chromatophores: Receptor Type, Signal Transduction, Second Messengers, and Cross Talk Among Multiple Signaling Cascades

Nitric oxide inhibited the melanophore aggregation induced by extracellular calcium concentration in snakehead fish, Channa punctatus

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