Nitric Oxide (NO) and Obstructive Sleep Apnea (OSA)

Haight, James S. J.; Djupesland, Per G.

doi:10.1007/s11325-003-0053-4

Cited by 63 publications

(49 citation statements)

References 77 publications

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“…18,19 Initially, OSAS was examined as one of the causes underlying intermittent failure to transport the full complement of nasal nitric oxide (NO) to the lung with each breath. 20 Although further study should be conducted to investigate the relationship between NO and OSAS, the impairment of the vasoprotective function of NO as a result of respiratory disturbances during nighttime sleep may explain the association between OSAS and ED. 21 Testosterone has been proposed as another linking factor between ED and hypoxia, though it is controversial.…”

Section: Erectile Dysfunction In Osas H-w Shin Et Almentioning

confidence: 99%

Erectile dysfunction and disease-specific quality of life in patients with obstructive sleep apnea

Han

et al. 2008

Int J Impot Res

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Several reports have suggested a high incidence of erectile dysfunction (ED) among patients with obstructive sleep apnea syndrome (OSAS). The aim of this study was to investigate the correlation between OSAS and ED, or disease-specific quality of life (QOL) in patients with OSAS. In addition, we analyzed specific polysomnographic (PSG) parameters in predicting ED in OSAS patients. In total, 32 patients with OSAS and 27 normal controls were asked to complete the Korean versions of the International Index of Erectile Function questionnaire (KIIEF-5) and the Calgary Sleep Apnea Quality of Life Index (SAQLI). All patients then underwent a full-night in-laboratory PSG examination. Patients were diagnosed with OSAS if they had clinical symptoms suggestive of OSAS for at least 1 year and an apnea-hypopnea index (AHI) of more than 10 in PSG. Nineteen patients (59.3%) in the OSAS group showed ED, which was significantly higher than in the control group (8 patients, 29.6%, P ¼ 0.012). In addition, SAQLI scores worsened as AHI increased (r ¼ 0.327, P ¼ 0.011) and as the lowest oxygen saturation level decreased (r ¼ 0.420, P ¼ 0.001). ED was not significantly correlated with AHI (r ¼ 0.061, P ¼ 0.649); however, it was significantly correlated with the lowest oxygen saturation decreased (r ¼ 0.338, P ¼ 0.009). When the cutoff value for the lowest oxygen saturation level to predict ED was set at 77%, its positive predictive value was 88.9% (sensitivity ¼ 0.70, specificity ¼ 0.62). Thus, all male patients with OSAS should be screened for erectile dysfunction and more comprehensive consultation is needed, especially, if their lowest oxygen saturation levels are below 77%.

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Section: Erectile Dysfunction In Osas H-w Shin Et Almentioning

confidence: 99%

Erectile dysfunction and disease-specific quality of life in patients with obstructive sleep apnea

Han

et al. 2008

Int J Impot Res

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“…Nitric oxide also suppresses the smooth muscle proliferation and induces apoptosis of these cells, providing beneficial effects on vascular remodeling [39]. Thus, long-term complications of OSA including systemic hypertension, pulmonary hypertension, myocardial infarction, and stroke might be influenced by dysregulated nitric oxide [40]. Experiments by Kato et al [41] showed that patients with OSA had a blunted vasodilation in response to acetylcholine, but not in response to sodium nitroprusside or verapamil, indicating that OSA patients have impaired resistance-vessel endothelium-dependent vasodilation, but the smooth muscle cell response itself is normal.…”

Section: Evidence For Altered Nitric Oxide Production In Osa Patientsmentioning

confidence: 99%

Oxidative stress and oxidant signaling in obstructive sleep apnea and associated cardiovascular diseases

Suzuki

Jain

Park

et al. 2006

Free Radical Biology and Medicine

205

123

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Obstructive sleep apnea (OSA) has emerged as a major public health problem and increasing evidence indicates that untreated OSA can lead to the development of various cardiovascular disorders. One important mechanism by which OSA may promote cardiovascular diseases is intermittent hypoxia, in which patients are subjected to repeated episodes of brief oxygen desaturation in the blood, followed by reoxygenation. Such cycles of hypoxia/reoxygenation may result in the generation of reactive oxygen species. Some studies have demonstrated the presence of oxidative stress in OSA patients as well as in animals subjected to intermittent hypoxia. Further, modulations of nitric oxide and biothiol status might also play important roles in the pathogenesis of OSA-associated diseases. Reactive oxygen species and redox events are also involved in the regulation of signal transduction for oxygen-sensing mechanisms. This review summarizes currently available information on the evidence for and against the occurrence of oxidative stress in OSA and the role of reactive oxygen species in cardiovascular changes associated with OSA.

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“…[7][8][9] NO and obstructive apnea are inseparable conditions. 10 Thus, the impairment of NO vasoprotective function may explain the association between OSAS and ED and may also indicate optimal therapeutic management.…”

Section: Introductionmentioning

confidence: 99%

Erectile dysfunction in men with obstructive sleep apnea syndrome: a randomized study of the efficacy of sildenafil and continuous positive airway pressure

et al. 2004

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The aim of this study was to compare the efficacy of sildenafil and continuous positive airway pressure (CPAP) in men with erectile dysfunction (ED) and obstructive sleep apnea syndrome (OSAS). In all, 30 men were randomly treated for 12 weeks either with sildenafil 100 mg before intercourse (15 men) or CPAP during night time sleep (15 men). Under sildenafil, 97/180 (53.9%) of attempted intercourses were successful compared to 33/138 (23.9%) under CPAP. The mean IIEF (erectile function domain score) was 12.9 and 9.3 after sildenafil and CPAP treatment, respectively (P ¼ 0.007), compared to 7.9 and 7 at baseline. In all, 53.3% of patients were satisfied with sildenafil and 20% with CPAP for ED treatment (P ¼ 0.058). Although sildenafil was superior to CPAP, comorbidities and OSAS per se possibly resulted in a lower effectiveness of sildenafil compared to that in the general population of ED men. While about half of the patients were not satisfied even with the more effective treatment, we conclude that a combination of the two therapeutic tools or a different therapeutic mode should be studied further.

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Nitric Oxide (NO) and Obstructive Sleep Apnea (OSA)

Cited by 63 publications

References 77 publications

Erectile dysfunction and disease-specific quality of life in patients with obstructive sleep apnea

Erectile dysfunction and disease-specific quality of life in patients with obstructive sleep apnea

Oxidative stress and oxidant signaling in obstructive sleep apnea and associated cardiovascular diseases

Erectile dysfunction in men with obstructive sleep apnea syndrome: a randomized study of the efficacy of sildenafil and continuous positive airway pressure

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