Nitric Oxide (NO) Production Inhibitory Constituents of Tabebuia avellanedae from Brazil

Awale, Suresh; Kawakami, Tsukasa; Tezuka, Yasuhiro; Ueda, Junichi; Tanaka, Ken; Kadota, Shigetoshi

doi:10.1248/cpb.53.710

Cited by 29 publications

(28 citation statements)

References 23 publications

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“…Byeon et al demonstrated that Tabebuia avellanedae negatively modulated macrophage-mediated inflammatory responses by suppressing PGE 2 production [6]. Awale et al reported that Tabebuia avellanedae suppressed the activity of macrophage-like J774.1 cells [8]. Neutrophils play an important role like macrophages in inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…Iridoids and phenylethanoid glycoside was shown to inhibit the activities of nitric oxide (NO) production in LPS-activated macrophagelike J774.1 cells [8]. Furano naphthoquinones and β-lapachone may mediate immune modulating activities in vitro [12].…”

Section: Discussionmentioning

confidence: 99%

“…Tabebuia avellanedae has also been used for various ethopharmacological treatments of bacterial infection, blood coagulation and cancer [4,5]. Moreover, recent studies have shown that Tabebuia avellanedae has some anti-inflammation and anti-oxidation properties [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Ingestion of Tabebuia avellanedae (Taheebo) Inhibits Production of Reactive Oxygen Species from Human Peripheral Blood Neutrophils

Ohno¹,

Ohno²,

Suzuki³

et al. 2015

IJFS

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Ingestion of Tabebuia avellanedae (Taheebo) Inhibits Production of Reactive Oxygen Species from Human Peripheral Blood Neutrophils

Ohno¹,

Ohno²,

Suzuki³

et al. 2015

IJFS

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“…In phytochemical studies involving H. impetiginosus, naphthoquinones, furanonaphthoquinones, anthraquinones, benzoic acid derivatives, benzaldehyde derivatives, iridoids, coumarins, flavonoids, and phenylpropanoid glycosides were isolated and identified (Ueda et al, 1994;Kreher et al, 1988;Pereira et al, 2006;Kim et al, 2007;Awale et al, 2005;Suo et al, 2013). Among the various quinones reported in the literature, lapachol and β-lapachone are of clinical importance because they have been associated with a variety of pharmacological activities (Oswald, 1993(Oswald, -1994Silva et al, 2003;Gómez Castellanos et al, 2009).…”

Section: Palavras-chavementioning

confidence: 99%

Reduction of doxorubicin-induced genotoxicity by Handroanthus impetiginosus in mouse bone marrow revealed by micronucleus assay

et al. 2017

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Handroanthus impetiginosus has long been used in traditional medicine and various studies have determined the presence of bioactive chemical compounds and potential phytotherapeutics. In this study, the genotoxicity of the lyophilized tincture of H. impetiginosus bark (THI) was evaluated in mouse bone marrow using micronucleus assays. The interaction between THI and genotoxic effects induced by the chemotherapeutic agent, doxorubicin (DXR), was also analyzed. Experimental groups were evaluated 24 to 48 h after treatment with N-nitroso-N-ethylurea (NEU; 50 mg/kg), DXR (5 mg/kg), sodium chloride (NaCl; 150 mM), and THI (0.5-2 g/kg). Antigenotoxic assays were carried out using THI (0.5 g/kg) in combination with NEU or DXR. Analysis of the micronucleated polychromatic erythrocytes (MNPCEs) indicated no significant differences between treatment doses of THI (0.5-2 g/kg) and NaCl. Polychromatic erythrocyte (PCE) to normochromatic erythrocyte (NCE) ratios did not indicate any statistical differences between DXR and THI or NaCl, but there were differences between THI and NaCl. A significant reduction in MNPCEs and PCE/NCE ratios was observed when THI was administered in combination with DXR. This study suggested the absence of THI genotoxicity that was dose-, time-, and gender-independent and the presence of moderate systemic toxicity that was dose-independent, but time-and gender-dependent. The combination of THI and DXR also suggested antigenotoxic effects, indicating that THI reduced genotoxic effects induced by chemotherapeutic agents.Keywords: Handroanthus impetiginosus (Mart. ex DC.) Mattos, phytotherapics, doxorubicin (DXR), micronucleus assay, bone marrow. Redução da genotoxicidade induzida pela doxorrubicina por Handroanthus impetiginosus na medula óssea de camundongos revelada pelo ensaio do micronúcleo ResumoHandroanthus impetiginosus tem sido usada durante um longo período pela medicina tradicional e vários estudos têm demonstrados a presença de compostos químicos e potencial fitoterapêutico. Esta pesquisa avaliou a genotoxicidade da tintura da casca liofilizada de H. impetiginosus (THI) usando o ensaio do micronúcleo em medula óssea de camundongos. A interação entre THI e os efeitos genotóxicos induzidos pelo quimioterápico doxorrubicina (DXR) também foram analisados. Grupos experimentais foram analisados a 24-48 h após o tratamento com N-Nitroso-N-etiluréia (NEU; 50 mg/kg), DXR (5 mg/kg), NaCl (150 mM) e THI (0,5-2 g/kg). O ensaio antigenotóxico foi conduzido utilizando THI (0,5 g/kg) em combinação com NEU ou DXR. A análise de eritrócitos policromáticos micronucleados (EPCMNs) não mostrou diferenças significativas entre as doses de tratamento (0,5-2 g/kg) e NaCl. As proporções de eritrócitos policromáticos (EPC)/eritrócitos normocromáticos (ENC) não revelaram diferenças estatísticas entre DXR e THI ou NaCl, porém houve diferenças entre THI e NaCl. Uma redução significativa em EPCMNs e na razão EPC/ENC foi observada quando THI foi administrado em combinação com DXR. Essa pesquisa sugere ausência de ...

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“…It has showy bright yellow, trumpet-shaped flowers from March to April in Okinawa as well as in many nations; it is planted as a roadside tree for ornamental purposes. Many phenolic glycosides and iridoid glucosides have been isolated from related species-T. impetiginosa [1]- [3] and T. avellanedae [4]. It has been reported that compounds isolated from T. avellanedae showed fairly strong nitric oxide production inhibitory activity [4], and a bark extract of T. avella-…”

Section: Introductionmentioning

confidence: 99%

Lignan Glycosides and Phenolic Compound Glycosides from the Branches of <i>Tabebuia chrysotricha</i>

Takahashi¹,

Kawakami²,

Sugimoto³

et al. 2015

AJPS

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From the branches of Tabebuia chrysotricha (Bignoniaceae), two lignan glycosides (1, 2) and two phenolic compound glycosides (3, 4) were isolated, along with 15 known compounds (5 -19). The structures of the new compounds were elucidated on the basis of spectroscopic evidence and those of the known compounds were identified by comparison of spectroscopic data with those reported in the literature. The DPPH radical-scavenging activity was assayed for the compounds isolated, the aryltetralin-type lignans showing moderate activity.

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Nitric Oxide (NO) Production Inhibitory Constituents of Tabebuia avellanedae from Brazil

Cited by 29 publications

References 23 publications

Ingestion of Tabebuia avellanedae (Taheebo) Inhibits Production of Reactive Oxygen Species from Human Peripheral Blood Neutrophils

Ingestion of Tabebuia avellanedae (Taheebo) Inhibits Production of Reactive Oxygen Species from Human Peripheral Blood Neutrophils

Reduction of doxorubicin-induced genotoxicity by Handroanthus impetiginosus in mouse bone marrow revealed by micronucleus assay

Lignan Glycosides and Phenolic Compound Glycosides from the Branches of <i>Tabebuia chrysotricha</i>

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Nitric Oxide (NO) Production Inhibitory Constituents of Tabebuia avellanedae from Brazil

Cited by 29 publications

References 23 publications

Ingestion of Tabebuia avellanedae (Taheebo) Inhibits Production of Reactive Oxygen Species from Human Peripheral Blood Neutrophils

Ingestion of Tabebuia avellanedae (Taheebo) Inhibits Production of Reactive Oxygen Species from Human Peripheral Blood Neutrophils

Reduction of doxorubicin-induced genotoxicity by Handroanthus impetiginosus in mouse bone marrow revealed by micronucleus assay

Lignan Glycosides and Phenolic Compound Glycosides from the Branches of &lt;i&gt;Tabebuia chrysotricha&lt;/i&gt;

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Lignan Glycosides and Phenolic Compound Glycosides from the Branches of <i>Tabebuia chrysotricha</i>