Nitric oxide: role in tumour biology and iNOS/NO-based anticancer therapies

Singh, Simendra; Gupta, Alok

doi:10.1007/s00280-011-1654-4

Cited by 182 publications

(167 citation statements)

References 106 publications

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“…Nitric oxide (NO), a soluble free radical gas, is synthesized from L-arginine through the activity of various NOS isoform enzymes (Singh et al, 2011). Lipopolysaccharide-induced macrophage activates iNOS isoform expression and NO production through the activation of NF-κB and MAPKs signaling pathway (Kim et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Eryngium foetidum Suppresses Inflammatory Mediators Produced by Macrophages

Mekhora

Muangnoi²,

Chingsuwanrote

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Eryngium foetidum Suppresses Inflammatory Mediators Produced by Macrophages

Mekhora

Muangnoi²,

Chingsuwanrote

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…In the present contribution, we report on the new [Ru II (CzT)(bipy)(NO)] 3+ complex { [2] 3+ in Scheme 1; CzT = 4′-(Nethylcarbazol-3-yl)-2,2′:6′,2′′-terpyridine}, a chromophore related to [1] 3+ in which the slightly electron-donating 9,9-dihexyl-9H-fluorene unit is replaced by 9-ethylcarbazole, which incorporates a tertiary amine that is conjugated within the three-cycle structure with the expected outcome of an enhanced push-pull effect directed towards the withdrawing Ru(NO) unit and hence a better TPA response. After describing undesirable [Ru II (terpyridine) 2 ] 2+ homoleptic species [13b] and 2) the tedious purification step required to separate the trans/cis isomers when two chlorides are present as ligands in the coordination sphere of the ruthenium center.…”

Section: Introductionmentioning

confidence: 99%

“…[1,2] However, at concentrations other than its physiological level, NO· can induce various cardiovascular, neurological, and pulmonary diseases as well as atherosclerosis and cancer. [3][4][5] In this context, there has been increasing interest in investigating exogenous donors capable of releasing NO· locally and quantitatively.…”

Section: Introductionmentioning

confidence: 99%

“…After describing undesirable [Ru II (terpyridine) 2 ] 2+ homoleptic species [13b] and 2) the tedious purification step required to separate the trans/cis isomers when two chlorides are present as ligands in the coordination sphere of the ruthenium center. [13a] The general route employed in the present investigation for the synthesis of [2](PF 6 ) 3 is shown in Scheme 2, which involves first the synthesis of the 4′-(N-ethylcarbazol-3-yl)-2,2′:6′,2′′-terpyridine ligand (E).…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Carbazole and Fluorene Donating Effects on the Two‐Photon Absorption and Nitric Oxide Photorelease Capabilities of a Ruthenium–Nitrosyl Complex

et al. 2017

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A ruthenium-nitrosyl derivative of formula [Ru II (CzT)(bipy)(NO)](PF 6 ) 3 [CzT = 4′-(N-ethylcarbazol-3-yl)-2,2′:6′,2′′-terpyridine, bipy = 2,2′-bipyridine] has been synthesized and fully characterized, and compared with the previously reported [Ru II (FT)(bipy)(NO)](PF 6 ) 3 complex [FT = 4′-(9,9-dihexyl-9H-fluoren-2-yl)-2,2′:6′,2′′-terpyridine]. Additionally, the Xray crystal structure of [Ru II (CzT)(bipy)(NO 2 )](PF 6 ), the precursor of [Ru II (CzT)(bipy)(NO)](PF 6 ) 3 , is reported. The presence of a ter-

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“…A terceira isoforma é induzível (iNOS ou NOS2). As isoformas "constitutiva" e "induzível" compartilham uma homologia de cerca de 50% dos aminoácidos Grupta, 2011). Todas as isoformas dependem do substrato L-arginina e dos cofatores/coenzimas NADPH, BH4, FAD, FMN, oxigênio e protoporfirina IX para sintetizar NO (Lechner et al, 2005).…”

Section: óXido Nítrico Sintase Induzível (Inos)unclassified

Resistência de células de carcinoma epidermóide bucal à terapia fotodinâmica mediada pelo ácido 5-aminolevulínico

Rosin¹

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A minha Orientadora, Prof a . Dr a . Luciana Corrêa, por sempre ouvir e discutir comigo todas as questões e dúvidas que surgiram durante o desenvolvimento desta tese e por ser essa pessoa tão generosa, inteligente e acessível. Admiro-a muito como pessoa e pesquisadora.Ao Prof. Dr. Moacir Novelli, que durante suas visitas ao laboratório sempre alegrava meu dia e por compartilhar comigo um pouco da sua imensa sabedoria. A Marina, a única companheira de profissão da Pós, que sempre esteve disposta a me ajudar e me ouvir, pela amizade, carinho e companheirismo. Pelos nossos cafés da manhã que sempre tornava meu dia mais leve e agradável.A Karla, pelo bom humor constante que sempre alegrava meu dia, por sempre me ouvir, me apoiar e pelos nossos cafezinhos.A Gabriela, por sempre estar ao meu lado me dando força e apoio, pelos nossos almoços diários na copa do departamento que tornavam meu dia mais alegre e por todo carinho e amizade.A Lara, pela amizade e por todo carinho e apoio. Por ser essa pessoa tão agradável e acessível por sempre estar disposta a me ourvir. Tenho a impressão de ter sido uma criança brincando à beira-mar, divertindo-me em descobrir uma pedrinha mais lisa ou uma concha mais bonita que as outras, enquanto o imenso oceano da verdade continua misterioso diante de meus olhos". Oral squamous cell carcinoma (SCC) is a malignant tumor with high morbidity and mortality rates, and it is difficult to treat. Conventional treatment for oral SCCs includes surgery and radiotherapy that may be followed by chemotherapy. Although these treatments are widely used, they are ineffective against some resistant tumors. Isaac Newton RESUMOOncologic photodynamic therapy (PDT) has been used as an adjuvant treatment for oral SCCs, especially in less invasive cases that require tumor reduction before surgical resection. However, like conventional treatments, PDT can induce the occurrence of resistant cell populations such as cutaneous carcinomas and colon and breast adenocarcinomas. The hypothesis that oral SCCs develop resistance to PDThas not yet been tested. Therefore, the aims of this study were to investigate whether oral SCCs (SCC9) develop resistance to several cycles of 5-aminolevulinic acidmediated PDT (5-ALA-PDT) and to determine whether the expression of markers associated with cell survival (NFB, Bcl-2, iNOS, mTOR, and Akt) is altered during this process. An oral SCC (SCC9) cell line was used, which was subjected to the following conditions: 1) Control: cultured without any treatment; 2) ALA: incubated with 5-ALA (1 mM for 4 h); 3) LED: treated with LED light (630 nm, 5.86 J/cm 2 , 22.5 J, 150 mW, 150 s); and 4) PDT: treated with 5-ALA-PDT (with the protocols of the ALA and LED groups combined) generating a lethal dose of 90%. Initially, only one cycle of PDT was administered, and cell viability was determined in all groups 24, 48, 72, and 120 h after irradiation. Subsequently, the DNA fragmentation detection assay (TUNEL) and immunofluorescence analysis of the expression of proteins NFB, Bcl-2, iNOS, pmTOR, ...

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Nitric oxide: role in tumour biology and iNOS/NO-based anticancer therapies

Cited by 182 publications

References 106 publications

Eryngium foetidum Suppresses Inflammatory Mediators Produced by Macrophages

Eryngium foetidum Suppresses Inflammatory Mediators Produced by Macrophages

Comparison of Carbazole and Fluorene Donating Effects on the Two‐Photon Absorption and Nitric Oxide Photorelease Capabilities of a Ruthenium–Nitrosyl Complex

Resistência de células de carcinoma epidermóide bucal à terapia fotodinâmica mediada pelo ácido 5-aminolevulínico

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