Abstract:Carbon dots (C-dots) prepared through heating of aminoguanidine and citric acid enable bimodal (colorimetric and fluorescence) detection of nitric oxide (NO) in aqueous solutions. The C-dots retained the functional units of aminoguanidine, which upon reaction with NO produced surface residues responsible for the color and fluorescence transformations. Notably, the aminoguanidine/citric acid C-dots were noncytotoxic, making possible real-time and high sensitivity detection of NO in cellular environments. Using … Show more
“… Galactose and m -aminophenyl boronic acid Blue Galactose [ 131 ] 9. Citric acid, aminoguanidine Blue Nitric oxide (NO) [ 132 ] 10. Citric acid and melamine Blue Glutathione [ 134 ] Fig.…”
Section: Applications Of Cdsmentioning
confidence: 99%
“…The boronic acid moiety present on the CD surface reacted with cis -diol units of galactose to give rise cyclic boronate esters, leading to quenching and selective detection of galactose in human urine [ 131 ]. Bhattacharya et al also used aminoguanidine based CDs for nitric oxide (NO) detection via formation of azo dye [ 132 ]. Recently Iqbal et al fabricated N-doped CDs from citric acid and melamine (passivation agent) and applied them for sensing glutathione and Hg 2+ in the biological system via fluorescence quenching [ 133 ].…”
Carbon dots (CDs) are the new fellow of carbon family having a size less than 10 nm and attracted much attention of researchers since the last decade because of their unique characteristics, such as inexpensive and facile synthesis methods, easy surface modification, excellent photoluminescence, outstanding water solubility, and low toxicity. Due to these unique characteristics, CDs have been extensively applied in different kind of scientific disciplines. For example in the photocatalytic reactions, drug-gene delivery system, in vitro and in vivo bioimaging, chemical and biological sensing as well as photodynamic and photothermal therapies. Mainly two types of methods are available in the literature to synthesize CDs: the top-down approach, which refers to breaking down a more massive carbon structure into nanoscale particles; the bottom-up approach, which refers to the synthesis of CDs from smaller carbon units (small organic molecules). Many review articles are available in the literature regarding the synthesis and applications of CDs. However, there is no such review article describing the synthesis and complete application of CDs derived from small organic molecules together. In this review, we have summarized the progress of research on CDs regarding its synthesis from small organic molecules (bottom-up approach) via hydrothermal/solvothermal treatment, microwave irradiation, ultrasonic treatment, and thermal decomposition techniques as well as applications in the field of bioimaging, drug/gene delivery system, fluorescence-based sensing, photocatalytic reactions, photo-dynamic therapy (PDT) and photo-thermal (PTT) therapy based on the available literature. Finally, the challenges and future direction of CDs are discussed.
“… Galactose and m -aminophenyl boronic acid Blue Galactose [ 131 ] 9. Citric acid, aminoguanidine Blue Nitric oxide (NO) [ 132 ] 10. Citric acid and melamine Blue Glutathione [ 134 ] Fig.…”
Section: Applications Of Cdsmentioning
confidence: 99%
“…The boronic acid moiety present on the CD surface reacted with cis -diol units of galactose to give rise cyclic boronate esters, leading to quenching and selective detection of galactose in human urine [ 131 ]. Bhattacharya et al also used aminoguanidine based CDs for nitric oxide (NO) detection via formation of azo dye [ 132 ]. Recently Iqbal et al fabricated N-doped CDs from citric acid and melamine (passivation agent) and applied them for sensing glutathione and Hg 2+ in the biological system via fluorescence quenching [ 133 ].…”
Carbon dots (CDs) are the new fellow of carbon family having a size less than 10 nm and attracted much attention of researchers since the last decade because of their unique characteristics, such as inexpensive and facile synthesis methods, easy surface modification, excellent photoluminescence, outstanding water solubility, and low toxicity. Due to these unique characteristics, CDs have been extensively applied in different kind of scientific disciplines. For example in the photocatalytic reactions, drug-gene delivery system, in vitro and in vivo bioimaging, chemical and biological sensing as well as photodynamic and photothermal therapies. Mainly two types of methods are available in the literature to synthesize CDs: the top-down approach, which refers to breaking down a more massive carbon structure into nanoscale particles; the bottom-up approach, which refers to the synthesis of CDs from smaller carbon units (small organic molecules). Many review articles are available in the literature regarding the synthesis and applications of CDs. However, there is no such review article describing the synthesis and complete application of CDs derived from small organic molecules together. In this review, we have summarized the progress of research on CDs regarding its synthesis from small organic molecules (bottom-up approach) via hydrothermal/solvothermal treatment, microwave irradiation, ultrasonic treatment, and thermal decomposition techniques as well as applications in the field of bioimaging, drug/gene delivery system, fluorescence-based sensing, photocatalytic reactions, photo-dynamic therapy (PDT) and photo-thermal (PTT) therapy based on the available literature. Finally, the challenges and future direction of CDs are discussed.
“…Recently, CDs have attracted tremendous attention because of their unique physical‐chemical characteristics and numerous exceptional advantages such as high chemical stability, low toxicity, high quantum yield, high‐fluorescence and excellent biocompatibility . Due to these unique properties, CDs have been applied widely in the fields of drug delivery, catalysis, chemical sensors,, biomedical application, biological sensors, nano‐biotechnology, etc. Although this nanomaterial holds great promise in a wide field of applications, considerable work in the sensing field is still required to develop the advanced smart sensors.…”
The fluorescent nanomaterial carbon dots (CDs) have attracted tremendous attention in the recent times because of their unique physico‐chemical characteristics. Highly fluorescent CDs were prepared through a simple and nontoxic one‐step hydrothermal carbonization of polyvinylpyrrolidone (PVP). The as‐synthesised CDs, without any pre‐treatments or post‐treatments, show high stability over a broad pH range and have an excellent potential in chemical sensing applications. The as‐prepared CDs have been demonstrated to be an excellent nano probe for Fe3+ ions sensing in aqueous media based on the fluorescence quenching with high sensitivity (lower limit of detection ∼ 1 μM) and selectivity towards Fe3+ ions. “Turn off” fluorescence arises due to the formation of CDs‐Fe3+ nanocomposite complex in the solution. The nanocomposite complex forms by the attachment of Fe3+ ions to the surface emissive site of the CDs, resulting in an obvious fluorescence quenching. Here, CDs itself act as a promising nano carrier for loading of Fe3+ ions to form the CDs‐Fe3+ nanocomposite complex in the solution. In addition to all, in this study we are intensely focused to explore the application of CDs‐Fe3+ nanocomposite complex. We have used the CDs‐Fe3+ nanocomposite complex as a novel sensor probe for the detection of F‐ ions in aqueous media based on “Turn on” fluorescence mechanism. “Turn on” fluorescence occurs due to the formation of thermodynamically highly stable [FeF6]3‐ complex and bare CDs in the solution. The developed sensor has high sensitivity (lower limit of detection ∼ 1 μM) and selectivity towards F‐ ions over a wide‐ranging other competing anions. Finally, we successfully demonstrate the real life application of the developed sensor by estimating the trace F‐ ions in the real world drinking water samples.
“…The solution phase detection technique has been used to sense various analytes such as small molecules, intracellular pH, macromolecules, cations, anions and moisture content. 16,79,[230][231][232][233][234][235][236] Solid phase detection, on the other hand, corresponds to utilization of fluorescent paper based or fingerprint-based sensing of various biomolecules, explosive compounds etc. 16,237,238 Apart from colorimetric detection, recent reports on the use of Cdots as an electrochemical sensing platform are worthy of mention.…”
The present review article focuses on novel findings corresponding to the structural and photophysical properties of carbon dots. The article also highlights unique characteristics of crystalline dots that offer new chemistry and thus new application potential.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
