Nitric oxide signalling in the brain and its control of bodily functions

Abstract

Funding information Agence Nationale de la Recherche, Grant/ Award Number: ANR-17-CE16-0015-01; Fédération Hospital-Universitaire "1000 days for health"; European Genomic Institute for Diabetes; LabEx DISTALZ Nitric oxide (NO) is a versatile molecule that plays key roles in the development and survival of mammalian species by endowing brain neuronal networks with the ability to make continual adjustments to function in response to moment-to-moment changes in physiological input. Here, we summarize the progress in the field and argue that NO-synthetizing neurons and NO signalling in the brain provide a core hub for integrating sensory-and homeostatic-related cues, control key bodily functions, and provide a potential target for new therapeutic opportunities against several neuroendocrine and behavioural abnormalities. 1 | INTRODUCTION Nitric oxide (NO), originally referred to as endothelium relaxing fac

Cannabinoid receptor type 1 in the bed nucleus of the stria terminalis modulates cardiovascular responses to stress via local N-methyl-D-aspartate receptor/neuronal nitric oxide synthase/soluble guanylate cyclase/protein kinase G signaling

“…Activation of the NMDA glutamatergic receptor in postsynaptic neurons results in NO formation through a Ca +2 -dependent mechanism and activation of the nNOS (Chachlaki and Prevot, 2019; Garthwaite, 2008, 2019). Accordingly, we recently reported that the facilitatory influence of the NMDA receptor within the BNST in stress-evoked cardiovascular responses is mediated by local nNOS activation (Barretto-de-Souza et al, 2018).…”

“…Activation of the NMDA glutamate receptor is the best characterized mechanism for activation of the neuronal isoform of the neuronal nitric oxide synthase (nNOS) enzyme in the brain (Chachlaki and Prevot, 2019; Garthwaite, 2008, 2019). Accordingly, a recent study identified that control of cardiovascular responses to restraint stress by NMDA receptor in the BNST is mediated by activation of local nNOS (Barretto-de-Souza et al, 2018).…”

“…Based on the evidence presented above, this study aimed to evaluate the hypothesis that the inhibitory influence of BNST endocannabinoid neurotransmission in the cardiovascular responses to acute restraint stress is mediated by an interaction with local NMDA glutamate receptor/nNOS signaling. We also evaluated the role of signaling mechanisms related to nitric oxide (NO) effects, such as soluble guanylate cyclase (sGC) and protein kinase G (PKG) (Chachlaki and Prevot, 2019; Garthwaite, 2019).…”

Hydrocephalus Revisited: New Insights into Dynamics of Neurofluids on Macro- and Microscales

“…71 Hence, alterations in the aquaporin system might be responsible for long-lasting or permanent adaptations of ventricular volumes after zero-gravity space flights and might be involved in many CSF disorders in which CSF dynamics are altered. A related pathway has been described for nitric oxide (NO), 72 which is delivered by neuronal or endothelial isozymes and is able to cross membranes 73,74 and AQP4 channels. It facilitates the motility and beating frequency of several ciliated epithelial cells.…”

Nitric oxide and sex differences in dendritic branching and arborization

“…All three NOSs are expressed in brain, but nNOS is the major source of NO in the nervous system. Additionally, nNOS is expressed throughout the brain during development, but the precise patterns and locations depend on the developmental stage, species, sex, brain region, and cell type of the organism (reviewed in Chachlaki & Prevot, 2020; Park et al., 2000). For example, nNOS is present in murine paraventricular nucleus (PVN) at early embryonic stages, indicating that it may be involved in the development of the PVN (McClellan et al., 2010).…”