“…With specific regard to epilepsy, nNOS has been shown to be upregulated in cortical neurons of epileptic patients (González-Hernández et al, 2000;Kamida et al, 2007;González-Martínez et al, 2009) and NO has been considered to play a fundamental role in the genesis and spreading of epileptiform hyperactivity and proposed as a possible therapeutic target (Yasuda et al, 2001;Jelenković et al, 2002;Kovács et al, 2009;Bahremand et al, 2010). However, although abundant experimental research has demonstrated a functional involvement of NO in the control of epileptic phenomena, the available data are conflicting and it cannot be concluded whether this atypical messenger acts as a pro-convulsant or an anticonvulsant agent (Barbiro-Michaely et al, 2011;Hrnčić et al, 2010Hrnčić et al, , 2011Przegaliñski et al, 1996;Tutka et al, 1997;Masukawa et al, 1998;Borowicz et al, 2000;Lesani et al, 2010;Łuszczki et al, 2006, 2011Sardo et al, 2008;Itoh and Watanabe, 2009;Nieoczym et al, 2010).…”