Nitroaromatic compounds: Environmental toxicity, carcinogenicity, mutagenicity, therapy and mechanism

Kovacic, Peter; Somanathan, Ratnasamy

doi:10.1002/jat.2980

Cited by 392 publications

(197 citation statements)

References 120 publications

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“…Physiological and biochemical characterization revealed that it is oxidase positive, urease positive, and catalase positive; ␤-glucosidase and ␤-galactosidase activities were absent. Phylogenetic analysis of strain ST-14 using the partial 16S rRNA gene sequence (1,393 Fig. S1 in the supplemental material).…”

Section: Isolation and Identification Of Mnba-degrading Bacteriamentioning

confidence: 99%

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Degradation Pathways of 2- and 4-Nitrobenzoates in Cupriavidus sp. Strain ST-14 and Construction of a Recombinant Strain, ST-14::3NBA, Capable of Degrading 3-Nitrobenzoate

Basu

Chowdhury

Deb

et al. 2016

Appl Environ Microbiol

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Strain ST-14, characterized as a member of the genus Cupriavidus, was capable of utilizing 2-and 4-nitrobenzoates individually as sole sources of carbon and energy. Biochemical studies revealed the assimilation of 2-and 4-nitrobenzoates via 3-hydroxyanthranilate and protocatechuate, respectively. Screening of a genomic fosmid library of strain ST-14 constructed in Escherichia coli identified two gene clusters, onb and pob-pca, to be responsible for the complete degradation of 2-nitrobenzoate and protocatechuate, respectively. Additionally, a gene segment (pnb) harboring the genes for the conversion of 4-nitrobenzoate to protocatechuate was unveiled by transposome mutagenesis. Reverse transcription-PCR analysis showed the polycistronic nature of the gene clusters, and their importance in the degradation of 2-and 4-nitrobenzoates was ascertained by gene knockout analysis. Cloning and expression of the relevant pathway genes revealed the transformation of 2-nitrobenzoate to 3-hydroxyanthranilate and of 4-nitrobenzoate to protocatechuate. Finally, incorporation of functional 3-nitrobenzoate dioxygenase into strain ST-14 allowed the recombinant strain to utilize 3-nitrobenzoate via the existing protocatechuate metabolic pathway, thereby allowing the degradation of all three isomers of mononitrobenzoate by a single bacterial strain. IMPORTANCEMononitrobenzoates are toxic chemicals largely used for the production of various value-added products and enter the ecosystem through industrial wastes. Bacteria capable of degrading mononitrobenzoates are relatively limited. Unlike other contaminants, these man-made chemicals have entered the environment since the last century, and it is believed that bacteria in nature evolved not quite efficiently to assimilate these compounds; as a consequence, to date, there are only a few reports on the bacterial degradation of one or more isomers of mononitrobenzoate. In the present study, fortunately, we have been able to isolate a Cupriavidus sp. strain capable of assimilating both 2-and 4-nitrobenzoates as the sole carbon source. Results of the biochemical and molecular characterization of catabolic genes responsible for the degradation of mononitrobenzoates led us to manipulate a single enzymatic step, allowing the recombinant host organism to expand its catabolic potential to assimilate 3-nitrobenzoate.

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Section: Isolation and Identification Of Mnba-degrading Bacteriamentioning

confidence: 99%

“…itroaromatic compounds are one of the most important groups of industrial chemicals and are currently considered to be priority environmental contaminants (1,2). Among the nitroaromatics, mononitrobenzoates (MNBAs) are widely employed in the production of dyes, plastics, explosives, pharmaceuticals, polyurethane foams, elastomers, and pesticides (3,4).…”

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confidence: 99%

Degradation Pathways of 2- and 4-Nitrobenzoates in Cupriavidus sp. Strain ST-14 and Construction of a Recombinant Strain, ST-14::3NBA, Capable of Degrading 3-Nitrobenzoate

Basu

Chowdhury

Deb

et al. 2016

Appl Environ Microbiol

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“…wood) burning (Iinuma et al, 2007;Iinuma et al, 2010;Kitanovski et al, 2012;Kahnt et al, 2013;Chow et al, 2016). NMAHs are ecotoxic (Pflieger and Kroflič, 2017) while little is known about human toxicity (Huang et al, 1995;Harrison et al, 2005;Kovacic and Somanathan, 2014). Due to nitrophenol 30 phytotoxic potential, the research on them in precipitation was fostered during the late 1980s and early 1990s in relation with research on forest decline in central Europe (Rippen et al, 1987;Leuenberger et al, 1988;Herterich and Herrmann, 1990).…”

Section: Introductionmentioning

confidence: 99%

Snow scavenging and phase partitioning of nitrated and oxygenated aromatic hydrocarbons in polluted and remote environments in central Europe and the European Arctic

Shahpoury¹,

Kitanovski²,

Lammel³

2018

Preprint

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Nitrated and oxygenated polycyclic aromatic hydrocarbons (N/OPAHs) are emitted in combustion processes and formed in polluted air. Their precipitation cycling has hardly been studied. Fresh snow samples at urban and rural sites in central Europe, as well as surface snow from a remote site in Svalbard were analysed for 17 NPAHs, 9 OPAHs, and 11 nitrated mono-aromatic hydrocarbons (NMAHs), of which most N/OPAHs as well as nitrocatechols, 5 nitrosalicylic acids, and 4-nitroguaiacol are studied for the first time in precipitation. In order to better understand the scavenging mechanisms, the particulate mass fractions (Ө) at 273K were predicted using a multiphase gas-particle partitioning model based on polyparameter linear free energy relationships. ∑NPAH concentrations were 1.2-17.6 and 8.8-19.1 ng L -1 at urban and rural sites, whereas ∑OPAHs were 0.3-1.1 and 0.5-2.4 µg L -1 at these sites, respectively.Acenaphthoquinone and 9,10-anthraquinone were predominant in snow dissolved and particulate phase, respectively. 10 NPAHs were only found in the particulate phase with 9-nitroanthracene being predominant followed by 2-nitrofluoranthene. Among NMAHs, 4-nitrophenol showed the highest abundance in both phases. The levels found for nitrophenols were in the same range or lower than those reported in the 1980s and 1990s. The lowest levels of ∑OPAHs and ∑NMAHs were found at the remote site (9.2 and 390.5 ng L -1 , respectively). N/OPAHs preferentially partitioned in snow particulate phase in accordance with predicted Ө, whereas NMAHs were predominant in the 15 dissolved phase, regardless of Ө. It is concluded that the phase distribution of non-polar N/OPAHs in snow is determined by their gas-particle partitioning prior to snow scavenging, whereas that for polar particulate phase substances, i.e. NMAHs, is determined by an interplay between gas-particle partitioning in the aerosol, particle mass size distribution, and dissolution during in-or below-cloud scavenging.Atmos. Chem. Phys. Discuss., https://doi

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“…Nitroaromatic compounds are generally used in many industries for the preparation of dyes, pharmaceuticals, rubber products, explosives, chemical fibres and pesticides, and so forth [1]. These nitroaromatic compounds were released into the environment as industrial wastage and are one of the main reasons for the pollution.…”

Section: Introductionmentioning

confidence: 99%

New Ni-Anthracene Complex for Selective and Sensitive Detection of 2,4,6-Trinitrophenol

Reddy

Kumar

Dhir

et al. 2018

International Journal of Spectroscopy

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Selective and sensitive detection of explosive materials through a simple approach is an attractive area of research having implications on public safety and homeland security. Considering this implication in mind, a new Ni-anthracene complex was designed and synthesized and has been demonstrated as an efficient fluorescence chemosensor for the selective and sensitive detection of 2,4,6-trinitrophenol. Firstly, a fluorescent anthracene ligand (A) was synthesized by treating anthracene-9-carboxaldehyde with 1,3-diaminopropane in presence of a weak acid. To achieve superior selectivity and great quenching efficiency for 2,4,6-trinitrophenol (TNP), a Ni complex, namely, [Ni( 2 -L)(NO 3 )] (B), was synthesized via the reaction of A with Ni(NO 3 ) 2 ⋅6H 2 O. Complex B showed strong emission peak ( max ) at 412 nm and exhibited high selectivity towards TNP among other nitroaromatics and anions. 100 equivalents of TNP made 95% fluorescence quenching of B and its detection limit for TNP was calculated as 2.8 M.

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Nitroaromatic compounds: Environmental toxicity, carcinogenicity, mutagenicity, therapy and mechanism

Cited by 392 publications

References 120 publications

Degradation Pathways of 2- and 4-Nitrobenzoates in Cupriavidus sp. Strain ST-14 and Construction of a Recombinant Strain, ST-14::3NBA, Capable of Degrading 3-Nitrobenzoate

Degradation Pathways of 2- and 4-Nitrobenzoates in Cupriavidus sp. Strain ST-14 and Construction of a Recombinant Strain, ST-14::3NBA, Capable of Degrading 3-Nitrobenzoate

Snow scavenging and phase partitioning of nitrated and oxygenated aromatic hydrocarbons in polluted and remote environments in central Europe and the European Arctic

New Ni-Anthracene Complex for Selective and Sensitive Detection of 2,4,6-Trinitrophenol

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