Nitrogen Balance in Experimental Tryptophane Deficiency in Man.

Abstract

ture resembles qualitatively, though obviously not quantitatively, that noted by Greep in his male and female parabionts, both under the stimulation of one pituitary. Parabiotic studies can thus not be regarded as evidence concerning the number of gonadotrophins secreted by the pituitary. Such evidence can be obtained only from the isolation of the pure hormones from the blood as it has been done from the pituitary.Summary. A mixture of purified FSH and ICSH was shown to produce predominantly follicle-stimulating effects in female and interstitial cell-stimulating effects in male hypophysectomized rats. These differences in the response of the two sexes were secured by the simultaneous adriiinistration of both hornioiies and it would consequently not seem valid to interpret such phenomena as evidence for the existence of a single pituitary gonadotrophin.The observations here reported comprise a part of a more comprehensive study undertaken jointly by the Departments of Medicine and Pediatrics of the Johns Hopkins University on experimental amino acid deficiencies in man. The purpose of this study was twofold. It was felt desirable to determine human amino acid requirements by direct observations on man, rather than by inferences based on animal experiments, since it is now known that even closely related animal species differ in their amino acid requirements. A second purpose was to discover whether deficiencies of particular amino acids produced characteristic pathological changes which could be recognized by clinical or laboratory technics. It seemed probable that, in certain parts of the world at least, specific amino acid deficiencies might be present, and that a familiarity with the picture,

Tryptophane and Its Relationship to Ascarid Infections in New Hampshire Chicks

“…The importance of tryptophane in a diet to maintain a proper nitrogen balance in man has been indicated by Holt et al (1941). In the chick tryptophane was necessary to promote growth (Grau and Almquist, 1944).…”

The Metabolism of Proteins and Amino Acids

“…Nitrogen equilibrium was readily maintained on an enzymic hydrolyzate of casein, but this was not possible with acid-hydrolyzed casein until tryptophan . �had been added (1,2). Two other acid hydrolyzates were prepared, one from casein which had been deaminized to destroy the lysine (3) and the other from casein which had been oxidized with hydrogen perox ide (4,5) to convert the methionine to the corresponding biologically inactive sulfone (6) which was removed as the insoluble calcium sul fonate.…”

“…During the year many delayed foreign journals have become available, but their arrival has been erratic and it has not been possible to fill some of the gaps. Throughout the review 1 and d have been used in the configurational sense.…”

The Nutritive Value of Human Plasma for the Rat

“…Protein appears to be of primary importance in many of these patients, and the huge losses of nitrogen after various types of injury have recently been stressed (5). Recent data also emphasize the very rapid response of the body to amino acid deficiencies, negative nitrogen balances being obtained within a few hours (6,7). The implication of these combined facts is that if patients are unable to take adequate diets, the intravenous nutrients, especially protein, should be as adequate as possible.…”