Nitrogen-Based Heterocyclic Compounds: A Promising Class of Antiviral Agents against Chikungunya Virus

Santana, Andreza C.; Filho, Ronaldo C. Silva; Menezes, José C. J. M. D. S.; Allonso, Diego; Campos, Vinícius R.

doi:10.3390/life11010016

Cited by 12 publications

(3 citation statements)

References 63 publications

(152 reference statements)

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“…Nitrogen-based heterocyclic systems are commonly found in pharmaceutical agents and natural products, and they have been intensively explored as new bioactive products [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. Among them, the indazoles [ 11 , 12 , 13 , 14 , 15 , 16 ] are favored by synthetic and medicinal chemists, as evidenced by their widespread abundance in pharmaceuticals and natural products.…”

Section: Introductionmentioning

confidence: 99%

Recent Strategies in Transition-Metal-Catalyzed Sequential C–H Activation/Annulation for One-Step Construction of Functionalized Indazole Derivatives

et al. 2022

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Designing new synthetic strategies for indazoles is a prominent topic in contemporary research. The transition-metal-catalyzed C–H activation/annulation sequence has arisen as a favorable tool to construct functionalized indazole derivatives with improved tolerance in medicinal applications, functional flexibility, and structural complexity. In the current review article, we aim to outline and summarize the most common synthetic protocols to use in the synthesis of target indazoles via a transition-metal-catalyzed C–H activation/annulation sequence for the one-step synthesis of functionalized indazole derivatives. We categorized the text according to the metal salts used in the reactions. Some metal salts were used as catalysts, and others may have been used as oxidants and/or for the activation of precatalysts. The roles of some metal salts in the corresponding reaction mechanisms have not been identified. It can be expected that the current synopsis will provide accessible practical guidance to colleagues interested in the subject.

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Section: Introductionmentioning

confidence: 99%

Recent Strategies in Transition-Metal-Catalyzed Sequential C–H Activation/Annulation for One-Step Construction of Functionalized Indazole Derivatives

et al. 2022

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“…Heterocyclic rings are the major component of medicinal chemistry and mostly present in biomolecules like enzyme, vitamins, and natural products. These have shown various biological activities such as insecticidal agents, 1 anti-HIV, 2,3 anti-viral, [4][5][6] and antimycobacterial, [7][8][9] antifungal, [10][11][12] antibacterial, 13-17 antioxidant, [18][19][20][21] anticonvulsant, 22 anti-allergic, [23][24] antibiotic, 25 herbicidal activity, 26,27 anticancer activity, [28][29][30][31] and antidiabetic. 32 Compounds having oxime ether moiety are extremely important not only for their diverse chemistry, but also for their numerous essential biological activities.…”

Section: Introductionmentioning

confidence: 99%

Synthetic Methods for the formation of Heterocyclic Compounds from Oxime Ether Derivatives

2022

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Heterocyclic ring compounds are not only ubiquitous in prime diversity of vital natural products and synthetic pharmaceuticals and thus highly important in organic synthesis. They have an extensive range of applications. They are mainly used as veterinary products and as agrochemicals. They are also utilized as corrosion inhibitors, sanitizers, antioxidants, dye stuff and as copolymers. They are accustomed as an important source in the synthesis of bioactive organic compounds. Some natural products like antibiotics such as tetracyclines, cephalosporin, penicillin, aminoglycosides, alkaloids such as morphine, vinblastine, atropine, reserpine, tryptamine, reserpine etc. have heterocyclic constituent. Hence, synthesis of heterocyclic compounds from new procedures have been always demanding. Due to wide range of applications of heterocyclic compounds, this study is a survey of literature of last one decade, describing the methods for the heterocyclic ring formation from the oxime ether.

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“…One or several nitrogen heteroatoms containing cycles have been largely described to have many pharmacological actions such as anticancer [ 7 ], antiviral [ 8 ], anti-inflammatory [ 9 ], antidiabetic [ 10 ], antihypertensive [ 11 ], antitubercular [ 12 ], bronchodilator, antimicrobial [ 13 ], anticonvulsant [ 14 ], are also used in the treatment of Alzheimer’s disease [ 15 ] etc.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Novel Thiazole Derivatives Bearing β-Amino Acid and Aromatic Moieties as Promising Scaffolds for the Development of New Antibacterial and Antifungal Candidates Targeting Multidrug-Resistant Pathogens

et al. 2021

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Rapidly growing antimicrobial resistance among clinically important bacterial and fungal pathogens accounts for high morbidity and mortality worldwide. Therefore, it is critical to look for new small molecules targeting multidrug-resistant pathogens. Herein, in this paper we report a synthesis, ADME properties, and in vitro antimicrobial activity characterization of novel thiazole derivatives bearing β-amino acid, azole, and aromatic moieties. The in silico ADME characterization revealed that compounds 1–9 meet at least 2 Lipinski drug-like properties while cytotoxicity studies demonstrated low cytotoxicity to Vero cells. Further in vitro antimicrobial activity characterization showed the selective and potent bactericidal activity of 2a–c against Gram-positive pathogens (MIC 1–64 µg/mL) with profound activity against S. aureus (MIC 1–2 µg/mL) harboring genetically defined resistance mechanisms. Furthermore, the compounds 2a–c exhibited antifungal activity against azole resistant A. fumigatus, while only 2b and 5a showed antifungal activity against multidrug resistant yeasts including Candida auris. Collectively, these results demonstrate that thiazole derivatives 2a–c and 5a could be further explored as a promising scaffold for future development of antifungal and antibacterial agents targeting highly resistant pathogenic microorganisms.

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Nitrogen-Based Heterocyclic Compounds: A Promising Class of Antiviral Agents against Chikungunya Virus

Cited by 12 publications

References 63 publications

Recent Strategies in Transition-Metal-Catalyzed Sequential C–H Activation/Annulation for One-Step Construction of Functionalized Indazole Derivatives

Recent Strategies in Transition-Metal-Catalyzed Sequential C–H Activation/Annulation for One-Step Construction of Functionalized Indazole Derivatives

Synthetic Methods for the formation of Heterocyclic Compounds from Oxime Ether Derivatives

Synthesis of Novel Thiazole Derivatives Bearing β-Amino Acid and Aromatic Moieties as Promising Scaffolds for the Development of New Antibacterial and Antifungal Candidates Targeting Multidrug-Resistant Pathogens

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