Nitrogen‐Doped Carbonized Polymer Dots: A Potent Scavenger and Detector Targeting Alzheimer's β‐Amyloid Plaques

Gao, Weiqun; Wang, Wenjuan; Dong, Xiaoyan; Sun, Yan

doi:10.1002/smll.202002804

Cited by 64 publications

(44 citation statements)

References 91 publications

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“…As shown in Figure 2 a, the green fluorescence signal of ThT-labeled Aβ40 aggregates decreased with the increase in the concentration of CPDs, which was due to the inhibitory effect of CPDs. Additionally, the interaction between CPDs and Aβ40 aggregates resulted in different red fluorescent plaques [ 84 ]. In addition to the application of carbon-based nanomaterials in the diagnosis and treatment of AD, they also have great potential in revealing the detailed functions and pathophysiology of the living brain.…”

Section: The Imaging Applications Of Inorganic Nanomaterials In Different Brain Disease Modelsmentioning

confidence: 99%

“… ( a ) FL of Aβ40 incubated with or without CPDs after 56 h at 37 °C, reprinted from [ 84 ]. Copyright 2020, with permission from Weily; ( b ) MRS spectra of subcutaneously transplanted glioma before and after the intratumoral injection of 1 mL AMSNs physiological saline solution (10 mg AMSNs/mL, 40 mg AMSNs/kg), reprinted from [ 77 ].…”

Section: The Imaging Applications Of Inorganic Nanomaterials In Different Brain Disease Modelsmentioning

confidence: 99%

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Inorganic Nanomaterial for Biomedical Imaging of Brain Diseases

Zhou

Zhang

et al. 2021

Molecules

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In the past few decades, brain diseases have taken a heavy toll on human health and social systems. Magnetic resonance imaging (MRI), photoacoustic imaging (PA), computed tomography (CT), and other imaging modes play important roles in disease prevention and treatment. However, the disadvantages of traditional imaging mode, such as long imaging time and large noise, limit the effective diagnosis of diseases, and reduce the precision treatment of diseases. The ever-growing applications of inorganic nanomaterials in biomedicine provide an exciting way to develop novel imaging systems. Moreover, these nanomaterials with special physicochemical characteristics can be modified by surface modification or combined with functional materials to improve targeting in different diseases of the brain to achieve accurate imaging of disease regions. This article reviews the potential applications of different types of inorganic nanomaterials in vivo imaging and in vitro detection of different brain disease models in recent years. In addition, the future trends, opportunities, and disadvantages of inorganic nanomaterials in the application of brain diseases are also discussed. Additionally, recommendations for improving the sensitivity and accuracy of inorganic nanomaterials in screening/diagnosis of brain diseases.

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Section: The Imaging Applications Of Inorganic Nanomaterials In Different Brain Disease Modelsmentioning

confidence: 99%

Section: The Imaging Applications Of Inorganic Nanomaterials In Different Brain Disease Modelsmentioning

confidence: 99%

Inorganic Nanomaterial for Biomedical Imaging of Brain Diseases

Zhou

Zhang

et al. 2021

Molecules

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“…Among them, CDs with red fluorescence possess several advantages of low biological fluorescence background signal and high tissue penetration ability. Recently, Gao et al discovered new functions of nitrogen-doped carbonized polymer dots (CPDs) to target Aβ aggregation [ 101 ]. The non-covalent interactions between Aβ aggregates and CPDs limited the molecular vibration and rotation of CPDs, resulting in the red emission.…”

Section: Nanomaterialsmentioning

confidence: 99%

“…(b) Fluorescent images of inhibiting Aβ deposits after treating without (b1,b2) or with (b3,b4) CPDs in CL2006 nematodes. Reprinted with permission from reference [ 101 ]. Copyright 2020 Wiley-VCH.…”

Section: Figures and Schemementioning

confidence: 99%

Nanomaterials for Modulating the Aggregation of β-Amyloid Peptides

et al. 2021

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The aberrant aggregation of amyloid-β (Aβ) peptides in the brain has been recognized as the major hallmark of Alzheimer’s disease (AD). Thus, the inhibition and dissociation of Aβ aggregation are believed to be effective therapeutic strategiesforthe prevention and treatment of AD. When integrated with traditional agents and biomolecules, nanomaterials can overcome their intrinsic shortcomings and boost their efficiency via synergistic effects. This article provides an overview of recent efforts to utilize nanomaterials with superior properties to propose effective platforms for AD treatment. The underlying mechanismsthat are involved in modulating Aβ aggregation are discussed. The summary of nanomaterials-based modulation of Aβ aggregation may help researchers to understand the critical roles in therapeutic agents and provide new insight into the exploration of more promising anti-amyloid agents and tactics in AD theranostics.

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“…Recently, ceramide nanomicelles and curcumin were studied. The use of these nanomicelles degraded the tau protein and induced autophagy that cumulatively resulted in an anti-Alzheimer's effect [156].…”

Section: Nanomicellarmentioning

confidence: 99%

Mechanisms Involved in Microglial-Interceded Alzheimer’s Disease and Nanocarrier-Based Treatment Approaches

Shadab

Alhakamy

Alfaleh

et al. 2021

JPM

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Alzheimer’s disease (AD) is a common neurodegenerative disorder accountable for dementia and cognitive dysfunction. The etiology of AD is complex and multifactorial in origin. The formation and deposition of amyloid-beta (Aβ), hyperphosphorylated tau protein, neuroinflammation, persistent oxidative stress, and alteration in signaling pathways have been extensively explored among the various etiological hallmarks. However, more recently, the immunogenic regulation of AD has been identified, and macroglial activation is considered a limiting factor in its etiological cascade. Macroglial activation causes neuroinflammation via modulation of the NLRP3/NF-kB/p38 MAPKs pathway and is also involved in tau pathology via modulation of the GSK-3β/p38 MAPK pathways. Additionally, microglial activation contributes to the discrete release of neurotransmitters and an altered neuronal synaptic plasticity. Therefore, activated microglial cells appear to be an emerging target for managing and treating AD. This review article discussed the pathology of microglial activation in AD and the role of various nanocarrier-based anti-Alzeihmenr’s therapeutic approaches that can either reverse or inhibit this activation. Thus, as a targeted drug delivery system, nanocarrier approaches could emerge as a novel means to overcome existing AD therapy limitations.

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Nitrogen‐Doped Carbonized Polymer Dots: A Potent Scavenger and Detector Targeting Alzheimer's β‐Amyloid Plaques

Cited by 64 publications

References 91 publications

Inorganic Nanomaterial for Biomedical Imaging of Brain Diseases

Inorganic Nanomaterial for Biomedical Imaging of Brain Diseases

Nanomaterials for Modulating the Aggregation of β-Amyloid Peptides

Mechanisms Involved in Microglial-Interceded Alzheimer’s Disease and Nanocarrier-Based Treatment Approaches

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