Nitrogen mustard and the steroid hormones in the treatment of inoperable bronchogenic carcinoma

Wolf, Julius; Spear, Paul W.; Yesner, Raymond; Patno, Mary Ellen

doi:10.1016/0002-9343(60)90081-4

Cited by 63 publications

(10 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are two randomized controlled trials of glucocorticoid monotherapy in lung cancer [ 10 , 41 , 42 ], with both being described in Table 12 . In the first trial, those in the glucocorticoid arm did worse than those in the placebo arm.…”

Section: Resultsmentioning

confidence: 99%

Systematic review of the clinical effect of glucocorticoids on nonhematologic malignancy

Keith

2008

BMC Cancer

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Systematic review of the clinical effect of glucocorticoids on nonhematologic malignancy

Keith

2008

BMC Cancer

View full text Add to dashboard Cite

show abstract

“…These observation could be confirmed by many authors (Table 7). [104][105][106] However, cortisone treatment has also been found to favor an increased metastatic spread in patients with breast carcinoma, 108,110 lung carcinoma 109 and renal carcinoma. 111 Recently, Sorensen et al 112 compared in a large population-based follow-up study among 59.043 individuals who received prescriptions for GCs, the observed and expected number of cases of skin cancer and non-Hodgkin lymphoma.…”

Section: Effect Of Hormonal Therapy On the Spreading Of Metastasesmentioning

confidence: 99%

Cell Cycle Arrest by Glucocorticoids May Protect Normal Tissue and Solid Tumors from Cancer Therapy

Mattern¹,

Büchler²,

Herr³

2007

Cancer Biology & Therapy

View full text Add to dashboard Cite

ABBrevIAtIons DEX ABstrActGlucocorticoids have been widely used as cotreatment for patients with cancer due to potent pro-apoptotic properties in lymphoid cells, reduction of nausea and diminishing acute toxicity on normal tissue. There are now data from preclinical and, to some extent, clinical studies, demonstrating that these medicaments are highly suspicious to induce therapy resistance in the majority of malignant solid tumors-irrespective of tumor origin and the nature of specific anticancer drugs or irradiation used for treatment. Despite these huge amounts of data, the underlying mechanisms of cell type-specific signaling by these steroid hormones are just beginning to be described. This review summarizes our present understanding of a relationship between glucocorticoid-induced reversible cell cycle arrest and therapy resistance in solid tumors. We give a summary of our current knowledge of decreased proliferation rates in response to glucocorticoid pre and combination treatment which are suspicious to be involved not only in protection of normal tissues, but also in protection of solid tumors from cytotoxic effects of anticancer agents. The inhibition of cell cycle progression by pretreatment with GCs may be crucially involved in switching the balance of several interacting pathways to survival upon treatment with GCs.

show abstract

“…Progress reports have been presented elsewhere (12,14,16,(33)(34)(35)(36) by the VA Lung Cancer Study Groups on the outcome for survival of (a) patients with disseminated lung cancer (drugs versus placebo), (b) individuals with localized, inoperable lung cancer (radiation versus drugs versus placebo), (c) operable cases (surgery versus preoperative radiation and surgery), and (d) resectable cases (surgery versus surgery and chemicals) (TABLE VI).…”

mentioning

confidence: 99%

The Survival of Patients with Inoperable Lung Cancer: A Large-Scale Randomized Study of Radiation Therapy Versus Placebo

Roswit¹,

Patno²,

Rapp³

et al. 1968

Radiology

Self Cite

271

View full text Add to dashboard Cite

Nitrogen mustard and the steroid hormones in the treatment of inoperable bronchogenic carcinoma

Cited by 63 publications

References 21 publications

Systematic review of the clinical effect of glucocorticoids on nonhematologic malignancy

Systematic review of the clinical effect of glucocorticoids on nonhematologic malignancy

Cell Cycle Arrest by Glucocorticoids May Protect Normal Tissue and Solid Tumors from Cancer Therapy

The Survival of Patients with Inoperable Lung Cancer: A Large-Scale Randomized Study of Radiation Therapy Versus Placebo

Contact Info

Product

Resources

About