2019
DOI: 10.1101/579896
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Nitroxide functionalized antibiotics are promising eradication agents against Staphylococcus aureus biofilms

Abstract: 24 Treatment of Staphylococcus aureus biofilm-related infections represents an important 25 medical challenge worldwide, as biofilms, even of drug-susceptible S. aureus strains, are 26 highly refectory to conventional antibiotic therapy. Nitroxides were recently shown to induce 27 dispersal of Gram-negative biofilms in vitro, but their action against Gram-positive bacterial 28 biofilms remains unknown. Here we demonstrate that the biofilm dispersal activity of 29 nitroxides extends to S. aureus, a clinically i… Show more

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Cited by 3 publications
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“…Robust biofilms can form on a wide range of materials, are difficult to eliminate once formed, and resist both antibiotics and the immune system [4,5]. As a result, biofilms are a large and growing problem in the healthcare industry, estimated to be found in 80% of all microbial infections [6][7][8]. Biofilms can grow on many types of medical devices, from catheters to implants [9][10][11][12].…”
Section: Introductionmentioning
confidence: 99%
“…Robust biofilms can form on a wide range of materials, are difficult to eliminate once formed, and resist both antibiotics and the immune system [4,5]. As a result, biofilms are a large and growing problem in the healthcare industry, estimated to be found in 80% of all microbial infections [6][7][8]. Biofilms can grow on many types of medical devices, from catheters to implants [9][10][11][12].…”
Section: Introductionmentioning
confidence: 99%