Nitroxide radical-containing nanoparticles attenuate tumorigenic potential of triple negative breast cancer

Shashni, Babita; Nagasaki, Yukio

doi:10.1016/j.biomaterials.2018.05.042

Cited by 48 publications

(36 citation statements)

References 48 publications

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“…Their actions on macromolecules can induce often irreversible damage [2] [3] [4]. It is generally recognized that the presence of free radicals contributes to the occurrence of serious diseases such as cancer, cirrhosis, diabetes, emphysema, cardiovascular diseases and rheumatism [5] [6] [7] [8].…”

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confidence: 99%

Evaluation of Phenolic Content and Antioxidant Activity of Aqueous Extracts of Three <i>Carica papaya</i> Varieties Cultivated in Senegal

Gaye¹,

Cisse²,

Ndiaye³

et al. 2019

FNS

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The aqueous extracts of different parts (old leaves (OL), young leaves (YL), peels (PE) and delipidated seed residues (DS)) of three varieties of papaya are studied. Extraction conditions are optimized: an extraction time of 20 minutes, a temperature of 70˚C and a plant material/water mixture of 1% give the best yield of polyphenol. The amount of polyphenols, flavonoids, saponins and proanthocyanins of each aqueous extract was investigated. Antioxidant activities are measured using two different methods (DPPH and ABTS). The delipidated seeds (DS) of V1 have the highest total phenolic content (TPC = 72.56 ± 3.16 mg GAE/g) while they have the lowest total flavonoid content (TFC = 0.22 ± 0.01). With regard to saponins, the PE of V3 is much richer in saponins (194.03 ± 15.78 mg AeE/g) than all the other extracts studied. The OL of V2 and PE of V1 contain the most proanthocyanidins with very similar values of 2.51 ± 0.03 mg CE/g and 2.53 ± 0.34 mg CE/g respectively. The study of the antioxidant activities of the extracts showed a correlation between the amount of polyphenols and IC50. DPPH OL and YL V2, which are rich in polyphenols, have the lowest IC50 of 0.072 mg/ml and 0.080 mg/ml respectively, whereas for ABTS we have PE of V1 that is very rich in polyphenols which has the smallest IC50 value of 0.218 mg/ml.

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confidence: 99%

Evaluation of Phenolic Content and Antioxidant Activity of Aqueous Extracts of Three <i>Carica papaya</i> Varieties Cultivated in Senegal

Gaye¹,

Cisse²,

Ndiaye³

et al. 2019

FNS

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“…29,30 It is worth noting that activation of the NF-κB signalling pathway led to increased DNA damage in inflammatory disease, 31,32 but it promotes cancer cell survival in many types of cancer. 33 The reason is that the effects of NF-κB depend on the stimulus factors and cell type, and it can suppress or induce autophagy in a context-dependent manner. 34 In the present study, inhibition of HIF-1α-mediated apoptosis and migratory characteristics of breast cancer cells, through inactivated of NF-κB pathway, was also confirmed (Figure 4).…”

Section: Discussionmentioning

confidence: 99%

Alpinetin inhibits breast cancer growth by ROS/NF‐κB/HIF‐1α axis

Zhang

Guo

Zhu

et al. 2020

J Cellular Molecular Medi

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Alpinetin, the main active ingredient in the Chinese medicinal herb Alpinia katsumadai Hayata , has been found to have anticancer activity. However, the therapeutic efficacy of signalling cascades modulated by alpinetin remains unknown. Here, we showed that alpinetin provoked mitochondria‐associated apoptosis in a dose‐dependent manner in breast cancer cells. Mechanistic investigations revealed that alpinetin dampens hypoxia‐inducible factor‐1α (HIF‐1α) signalling due to a lack of NF‐κB activation through reduced mitochondrial reactive oxygen species (ROS) production, decreasing HIF‐1α transcription. In vivo, we also found alpinetin led to significant tumour regression by inhibiting NF‐κB pathway. Overall, our work uncovers a ROS/NF‐κB/HIF‐1α axis‐dependent mechanism underlying the anticancer effects of alpinetin and suggests that alpinetin could act as a novel therapeutic agent against breast cancer.

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“…As a representative example, antioxidative nanotherapies self-assembled by integrating a stable nitroxide radical-containing ROS trapper, 4-hydroxy-2,2,6,6tetramethylpiperidin-1-oxyl (Tempol) into the side chain of amphiphilic copolymers have been intensively investigated by Nagasaki's group Ikeda and Nagasaki, 2018). Two types of redox nanoparticles (RNPs), pHsensitive RNP N and pH-insensitive RNP O have been synthesized and demonstrated remarkable protective and therapeutic effects in diverse diseases, such as breast or colon cancers (Vong and Nagasaki, 2016;Shashni and Nagasaki, 2018), IBD (Vong et al, 2012(Vong et al, , 2014, radiation-induced organ dysfunctions (Feliciano et al, 2017), ischemia reperfusion injury (Yoshitomi et al, 2011), non-alcoholic steatohepatitis (Eguchi et al, 2015), and neurological deficit (Chonpathompikunlert et al, 2012). These studies have unambiguously substantiated the antioxidative effects of RNP N and RNP O without discernible adverse side effects.…”

Section: Free Radical-containing Organic Nanoparticlesmentioning

confidence: 99%

Antioxidant Nanotherapies for the Treatment of Inflammatory Diseases

Chen

et al. 2020

Front. Bioeng. Biotechnol.

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Reactive oxygen species (ROS) are essential in regulating various physiological functions. However, overproduction of ROS is implicated in the pathogenesis of various inflammatory diseases. Antioxidant therapy has thus represented an effective strategy for the treatment of oxidative stress relevant inflammatory diseases. Conventional anti-oxidative agents showed limited in vivo effects owing to their non-specific distribution and low retention in disease sites. Over the past decades, significant achievements have been made in the development of antioxidant nanotherapies that exhibit multiple advantages such as excellent pharmacokinetics, stable anti-oxidative activity, and intrinsic ROS-scavenging properties. This review provides a comprehensive overview on recent advances in antioxidant nanotherapies, including ROS-scavenging inorganic nanoparticles, organic nanoparticles with intrinsic antioxidant activity, and drug-loaded anti-oxidant nanoparticles. We highlight the biomedical applications of antioxidant nanotherapies in the treatment of different inflammatory diseases, with an emphasis on inflammatory bowel disease, cardiovascular disease, and brain diseases. Current challenges and future perspectives to promote clinical translation of antioxidant nanotherapies are also briefly discussed.

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Nitroxide radical-containing nanoparticles attenuate tumorigenic potential of triple negative breast cancer

Cited by 48 publications

References 48 publications

Evaluation of Phenolic Content and Antioxidant Activity of Aqueous Extracts of Three <i>Carica papaya</i> Varieties Cultivated in Senegal

Evaluation of Phenolic Content and Antioxidant Activity of Aqueous Extracts of Three <i>Carica papaya</i> Varieties Cultivated in Senegal

Alpinetin inhibits breast cancer growth by ROS/NF‐κB/HIF‐1α axis

Antioxidant Nanotherapies for the Treatment of Inflammatory Diseases

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Nitroxide radical-containing nanoparticles attenuate tumorigenic potential of triple negative breast cancer

Cited by 48 publications

References 48 publications

Evaluation of Phenolic Content and Antioxidant Activity of Aqueous Extracts of Three &lt;i&gt;Carica papaya&lt;/i&gt; Varieties Cultivated in Senegal

Evaluation of Phenolic Content and Antioxidant Activity of Aqueous Extracts of Three &lt;i&gt;Carica papaya&lt;/i&gt; Varieties Cultivated in Senegal

Alpinetin inhibits breast cancer growth by ROS/NF‐κB/HIF‐1α axis

Antioxidant Nanotherapies for the Treatment of Inflammatory Diseases

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Product

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Evaluation of Phenolic Content and Antioxidant Activity of Aqueous Extracts of Three <i>Carica papaya</i> Varieties Cultivated in Senegal

Evaluation of Phenolic Content and Antioxidant Activity of Aqueous Extracts of Three <i>Carica papaya</i> Varieties Cultivated in Senegal